1.1.1.14: L-iditol 2-dehydrogenase
This is an abbreviated version!
For detailed information about L-iditol 2-dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.14
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1.1.1.14
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polyols
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aminotransferase
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aldose
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hepatotoxicity
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fructose
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necrosis
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transaminase
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dehydrogenases
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bile
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lens
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alt
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sheep
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bilirubin
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gamma-glutamyl
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testicular
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cataract
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transpeptidase
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gluconobacter
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ccl4
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acetaminophen
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tetrachloride
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centrilobular
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xylitol
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oxydans
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hepatoprotective
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galactitol
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apap
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ribitol
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acetaminophen-induced
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diapause
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pneumotoxicity
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bromobenzene
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13-week
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n-demethylase
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d-mannitol
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forestomach
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hepatotoxicants
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fructokinase
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l-sorbose
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aminopyrine
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glutamic-pyruvic
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sorbinil
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medicine
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agriculture
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synthesis
- 1.1.1.14
- polyols
- aminotransferase
- aldose
-
hepatotoxicity
- fructose
- necrosis
- transaminase
- dehydrogenases
- bile
- lens
-
alt
- sheep
- bilirubin
-
gamma-glutamyl
- testicular
- cataract
- transpeptidase
- gluconobacter
- ccl4
- acetaminophen
-
tetrachloride
-
centrilobular
- xylitol
- oxydans
-
hepatoprotective
- galactitol
- apap
- ribitol
-
acetaminophen-induced
-
diapause
-
pneumotoxicity
- bromobenzene
-
13-week
- n-demethylase
- d-mannitol
-
forestomach
-
hepatotoxicants
- fructokinase
- l-sorbose
- aminopyrine
-
glutamic-pyruvic
- sorbinil
- medicine
- agriculture
- synthesis
Reaction
Synonyms
ADH, D-sorbitol dehydrogenase, dehydrogenase, L-iditol, Dgeo_2865, glucitol dehydrogenase, GoSCR, L-iditol 2-dehydrogenase, L-iditol dehydrogenase (sorbitol), L-iditol:NAD oxidoreductase, L-iditol:NAD+ 5-oxidoreductase, LeSDH, MdSDH5, More, NAD+-dependent sorbitol dehydrogenase, NAD-dependent polyol dehydrogenase, NAD-dependent sorbitol dehydrogenase, NAD-SDH, NAD-sorbitol dehydrogenase, PDH-11300, polyol dehydrogenase, Protein tms1, SDH, SldA, SLDH, SOR, Sor1, Sor2, sorbitol dehydrogenase, sorbitol dehydrogenase 1, sorbitol dehydrogenase 2, sorbitol related enzyme, SORD
ECTree
1.1.1.14 L-iditol 2-dehydrogenaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.1.1.14 - L-iditol 2-dehydrogenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
6-deoxy-D-sorbitol + NAD+
? + NADH
-
nearly 2fold higher activity compared to D-sorbitol
-
-
?
6-fluoro-D-sorbitol + NAD+
? + NADH
-
over 2fold higher activity compared to D-sorbitol, best substrate
-
-
?
D-sorbitol + 2,6-dichlorophenolindophenol
L-sorbose + ?
-
electron acceptor: i.e. DCIP
-
-
?
D-xylitol + NADP+
? + NADPH + H+
NADP+ is not a cofactor for wild-type, but for a substrate-binding loop chimera
-
-
?
2-hydroxyacetophenone + NADH + H+
(S)-1-phenyl-1,2-ethanediol + NAD+
-
-
-
?
2-hydroxyacetophenone + NADH + H+
(S)-1-phenyl-1,2-ethanediol + NAD+
99% enantiomeric excess
-
-
?
2-hydroxyacetophenone + NADH + H+
(S)-1-phenyl-1,2-ethanediol + NAD+
-
-
-
?
2-hydroxyacetophenone + NADH + H+
(S)-1-phenyl-1,2-ethanediol + NAD+
99% enantiomeric excess
-
-
?
D-arabitol + NAD(P)+
D-xylulose + NAD(P)H + H+
-
-
-
?
D-arabitol + NAD+
?
Cereibacter sphaeroides Si4 / DSM 8371
-
D-arabinitol is identical, low activity
-
-
?
D-arabitol + NAD+
D-xylulose + NADH + H+
-
best substrate
-
-
?
D-mannitol + NAD(P)+
D-fructose + NAD(P)H + H+
-
-
-
?
D-sorbitol + NAD(P)+
L-sorbose + NAD(P)H + H+
-
-
-
?
D-sorbitol + NAD+
D-fructose + NADH + H+
Cereibacter sphaeroides Si4 / DSM 8371
-
-
-
r
D-sorbitol + NAD+
D-fructose + NADH + H+
-
second step of the polyol pathway of glucose metabolism, important in diabetic disease and hyperglycaemia
-
-
?
D-sorbitol + NAD+
D-fructose + NADH + H+
-
i.e. D-glucitol, dissociation of the enzyme-coenzyme binary complex is the rate-limiting step, interaction of Zn2+ with Ser46 and the oxygen atom of the 2-hydroxy and the 4-hydroxy groups is important for substrate binding
-
-
?
D-sorbitol + NAD+
D-fructose + NADH + H+
-
second step of the polyol pathway of glucose metabolism
-
-
?
D-sorbitol + NAD+
D-fructose + NADH + H+
-
i.e. D-glucitol, dissociation of the enzyme-coenzyme binary complex is the rate-limiting step
-
-
?
D-sorbitol + NAD+
D-fructose + NADH + H+
-
-
-
-
?
D-sorbitol + NAD+
D-fructose + NADH + H+
-
second step of the polyol pathway of glucose metabolism
-
-
?
D-sorbitol + NAD+
D-fructose + NADH + H+
-
i.e. D-glucitol, dissociation of the enzyme-coenzyme binary complex is the rate-limiting step, 2- and 4-hydroxy groups of D-sorbitol are important for substrate bindig
-
-
?
D-sorbitol + NAD+
D-fructose + NADH + H+
-
-
-
-
?
D-sorbitol + NAD+
D-fructose + NADH + H+
-
second step of the polyol pathway of glucose metabolism
-
-
?
D-sorbitol + NAD+
D-fructose + NADH + H+
-
i.e. D-glucitol, dissociation of the enzyme-coenzyme binary complex is the rate-limiting step
-
-
?
D-sorbitol + NAD+
L-sorbose + NADH + H+
-
enzyme is the main L-sorbose producing activity in the cell
-
-
?
D-sorbitol + NAD+
L-sorbose + NADH + H+
-
enzyme is the main L-sorbose producing activity in the cell
-
-
?
D-sorbitol + NAD+
L-sorbose + NADH + H+
part of the polyol pathway that interconverts glucose and fructose
-
-
?
D-sorbitol + NAD+
L-sorbose + NADH + H+
the primary enzyme responsible for metabolism of the major phloem-transported carbohydrate sorbitol, present and active during apple fruit set and early development
-
-
?
additional information
?
-
-
no activity with D-glucose, D-fructose, L-sorbose, methanol, ethanol, and sucrose
-
-
?
additional information
?
-
no activity against D-xylitol, D-ribitol, D-inositol or glycerol
-
-
?
additional information
?
-
-
no activity against D-xylitol, D-ribitol, D-inositol or glycerol
-
-
?
additional information
?
-
an enantiocomplementary carbonyl reductase, polyol dehydrogenase (GoSCR) from Gluconobacter oxydans is discovered to convert 2-hydroxyacetophenone (2-HAP) to (S)-1-phenyl-1,2-ethanediol ((S)-PED) with excellent stereochemical selectivity. No activity with NADPH
-
-
-
additional information
?
-
an enantiocomplementary carbonyl reductase, polyol dehydrogenase (GoSCR) from Gluconobacter oxydans is discovered to convert 2-hydroxyacetophenone (2-HAP) to (S)-1-phenyl-1,2-ethanediol ((S)-PED) with excellent stereochemical selectivity. No activity with NADPH
-
-
-
additional information
?
-
no activity against D-xylitol, D-ribitol, D-inositol or glycerol
-
-
?
additional information
?
-
-
no activity against D-xylitol, D-ribitol, D-inositol or glycerol
-
-
?
additional information
?
-
-
no activity with D-glucose, D-fructose, L-sorbose, methanol, ethanol, and sucrose
-
-
?
additional information
?
-
-
no activity with 2-deoxy-D-sorbitol and 2-fluoro-D-sorbitol, 3-fluoro-D-sorbitol and 4-fluoro-D-sorbitol are poor substrates
-
-
?
