Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
brenda
-
non-small cell lung carcinoma cell line A549, expression of 15-PGDH is induced by dexamethason, prednisolone, betamethasone and triamcinolone
brenda
-
both 15-hydroxyprostaglandin dehydrogenase mRNA and protein levels are significantly higher in kidney cortex than in papilla. Enzyme is mainly localized to the tubular epithelial cells in kidney cortex and outer medulla
brenda
-
55000 Da form of enzyme, level increases with preterm premature rupture of membrane
brenda
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
brenda
-
brenda
-
brenda
-
-
brenda
-
low expression
brenda
-
brenda
-
low enzyme expression level
brenda
-
-
brenda
-
brenda
-
lung adenocarcinoma cell line
brenda
-
brenda
15-hydroxyprostaglandin dehydrogenase is expressed mainly in keratinocytes and melanocytes
brenda
-
-
brenda
-
-
brenda
-
erythroleukemia cell line
brenda
-
brenda
-
brenda
-
brenda
-
brenda
-
brenda
-
brenda
invasiveapocrine carcinoma cells correspond to a distinct molecular subtype of breast carcinomas characterized by the expression of 15-prostaglandin dehydrogenase alone or in combination with a novel form of acyl-CoA synthetase medium-chain family member 1, 15-prostaglandin dehydrogenase is not expressed by other breast cancer types
brenda
in hair follicle, 15-hydroxyprostaglandin dehydrogenase is expressed mainly in keratinocytes and melanocytes
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
intense immunofluorescent staining for 15-hydroxyprostaglandin dehydrogenase in macula densa and glomerulus of cyclooxygenase-2 knock-out mice
brenda
-
high enzyme expression level
brenda
-
-
brenda
in hair follicle, 15-hydroxyprostaglandin dehydrogenase is expressed mainly in keratinocytes and melanocytes
brenda
-
brenda
-
high expression level of 15-PGDH
brenda
-
macula densa cell line, significantly lower enzyme levels than in a proximal tubule cell line. Treatment with an inhibitor of cyclooxygenase-2 increases enzyme level
brenda
-
-
brenda
-
enzyme activity is reduced in inflamed mucosa
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
intense immunofluorescent staining for 15-hydroxyprostaglandin dehydrogenase in macula densa and glomerulus of cyclooxygenase-2 knock-out mice
brenda
-
-
brenda
-
enzyme is mainly localized to the tubular epithelial cells in kidney cortex and outer medulla
brenda
-
low expression level of 15-PGDH
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
very low enzyme expression level
brenda
-
low enzyme expression level
brenda
-
-
brenda
-
-
brenda
-
brenda
the enzyme is expressed mainly in the glandular epithelium, enzyme activity during the oestrous cycle and early pregnancy, overview
brenda
-
brenda
-
brenda
-
PGDH messenger RNA (mRNA) abundance decreases significantly in the visceral yolk sac membrane and the amnion throughout the last third of pregnancy
brenda
-
-
brenda
-
-
brenda
-
brenda
-
lung adenocarcinoma cell line
brenda
-
up-regulation of cyclooxygenase-2 expression by pro-inflammatory cytokines is accompanied by down-regluation of 15-hydroxyprostaglandin dehydrogenase expression. Over-expression of cyclooxygenase-2 but not -1 also attenuates 15-hydroxyprostaglandin dehydrogenase expression. Similarly, overexpression of 15-hydroxyprostaglandin dehydrogenase inhibits interleukin 1beta-induced cyclooxygenase-2 expression and results in apoptosis. The levels of 15-hydroxyprostaglandin dehydrogenase expression in transfected cells correlate positively with those of mesenchymal markers, and negatively with those of epithelial markers
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
expression of the enzyme and the estrogen receptor is correlated
brenda
-
in preterm chorion, levles of 15-hydroxyprostaglandin dehydrogenase protein and activity are lower when compared to term, and are further reduced with the presence of infection. Preterm premature rapture of membranes and subclinical inflammation do not affect the levels of 29000 Da 15-hydroxyprostaglandin dehydrogenase protein in the fetal membranes
brenda
-
extravillous trophoblasts layer
brenda
-
-
brenda
-
distribution of enzyme expression within the tissue in situ, overview
brenda
-
distribution of enzyme expression within the tissue in situ, overview
-
brenda
-
-
brenda
-
highly reduced enzyme expression in colon cancers, distribution of enzyme expression within the tissue in situ, overview
brenda
-
highly reduced enzyme expression in colon cancers, distribution of enzyme expression within the tissue in situ, overview
-
brenda
-
-
brenda
-
the enzyme expression is down-regulated
brenda
-
-
brenda
-
low enzyme expression level
brenda
-
-
brenda
-
low enzyme expression level
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
very low enzyme expression level
brenda
-
colon cancer cell line
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
very low expression level
brenda
-
low enzyme expression level
brenda
-
intense immunofluorescent staining for 15-hydroxyprostaglandin dehydrogenase in macula densa and glomerulus of cyclooxygenase-2 knock-out mice
brenda
-
cortex
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
medulla, cortex
brenda
-
-
brenda
-
-
brenda
-
high enzyme expression level
brenda
generation of transgenic mice with targeted expression of 15-hydroxyprostaglandin dehydrogenase in the liver
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
very low enzyme expression level
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
high enzyme expression level
brenda
-
-
brenda
-
of 28-days-old pregnant rabbits
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
loss of 15-hydroxyprostaglandin expression in 65% of lung cancers. Enzyme acts as a tumor suppressor in lung cancer
brenda
-
brenda
-
low enzyme expression level
brenda
-
-
brenda
-
NSCLC cell, much lower expression of 15-hydroxyprostaglandin dehydrogenase in all NSCLC histologic groups compared with healthy lung cell. Treatment with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib increases the expression of the enzyme in a subset of NSCLC lines
brenda
-
reduced expression of 15-PGDH occurrs in tumor cells and is paralleled by decreased 15-PGDH activity in tumors
brenda
-
the amount of 15-PGDH is frequently decreased in NSCLC cells compared with adjacent normal lung
brenda
-
-
brenda
-
low enzyme expression level
brenda
-
brenda
-
-
285914, 285915, 285916, 285919, 285920, 285922, 285923, 285927, 285932, 285933, 285934, 285935, 285937, 654361, 657210, 711448 brenda
-
-
brenda
-
PGDH protein is concentrated in the parietal yolk sac membrane (PYS) lining the placental surface and in placental blood vessels
brenda
-
androgen-sensitive cancer cells LNCaP and hormone-independent PC3 cells, enzyme expression is induced by steroids
brenda
-
very low expression level
brenda
-
-
brenda
-
-
brenda
-
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
low enzyme expression level
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
very low enzyme expression level
brenda
additional information
-
distribution of enzyme expression in normal and pathological tissues, overview, no enzyme expression in spleen, heart, HCT-116 cells, CacO-2 cells and Colo 201 cells
brenda
additional information
-
enzyme expression analysis, PGDH expression is repressed in multiple human cancers
brenda
additional information
-
tissue distribution, overview
brenda
additional information
-
tissue distribution of enzyme expression, overview, no expression in heart and brain
brenda
additional information
-
a 42- to 55-fold induction of the PGDH activity is observed after 20 days of gestation in pregnant rabbits
brenda