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1,2-dehydrocortisol + NADP+
1,2-dehydrocortisone + NADPH
-
-
-
-
r
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
11-dehydrocorticosterone + NADPH + H+
corticosterone + NADP+
-
-
-
?
11alpha-hydroxy-pregn-4-ene-3,20-dione + ?
pregn-4-ene-3,11,20-trione + ?
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + ?
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + ?
-
i.e. cortisol
-
?
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17beta-dihydroxyandrost-4-ene-3-one + ?
17beta-hydroxyandrost-4-ene-3,11-dione + ?
11beta,20alpha-dihydroxypregn-4-ene-3-one + ?
20alpha-hydroxypregn-4-ene-3,11-dione + ?
11beta,20beta-dihydroxypregn-4-ene-3-one + ?
20beta-hydroxypregn-4-ene-3,11-dione + ?
11beta,21-dihydroxypregn-4-en-3,20-dione + ?
11-dehydro,21-hydroxy-pregn-4-en-3,20-dione + ?
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+
11beta-hydroxy-pregn-4-ene-3,20-dione + ?
pregn-4-ene-3,11,20-trione + ?
11beta-hydroxyandrost-4-ene-3,17-dione + ?
androst-4-ene-3,11,17-trione + ?
11beta-hydroxytestosterone + NAD+
11-oxotestosterone + NADH + H+
-
-
-
-
?
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
17alpha,21-dihydroxypregna-1,4-diene-3,11,20-trione + NADPH
11beta,17alpha,21-trihydroxypregna-1,4-diene-3,20-dione + NADP+
-
i.e. prednisone
i.e. prednisolone
?
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
4-methylnitrosamino-1-(3-pyridyl)-1-butanone + NADPH
4-methylnitrosamino-1-(3-pyridyl)-1-butanol + NADP+
-
i.e. NNK, genotoxic compound from tobacco smoke, isozyme 11beta-HSD1, carbonyl reductase activity, EC 1.1.1.184
-
-
r
7-keto,27-hydroxycholesterol + NADP+
7beta,27-dihydroxycholesterol + NADPH + H+
the reaction is catalyzed by isoform 11beta-HSD1
-
-
r
7-oxo-cholesterol + NADP+
7beta-hydroxycholesterol + NADPH + H+
-
-
-
?
7beta,27-dihydroxycholesterol + NADH + H+
7-keto,27-hydroxycholesterol + NAD+
the reaction is catalyzed by isoform 11beta-HSD2
-
-
r
7beta-hydroxycholesterol + NADP+
7-oxocholesterol + NADPH
androstenedione + NADPH + H+
testosterone + NADP+
the two reactions 11beta-HSD1-dehydrogenase, EC 1.1.1146, and 17beta-HSD3, EC 1.1.1.64, which utilize NADPH are competing for NADPH from the same cofactor pool. 11beta-HSD1-dehydrogenase serves as a NADPH-regenerating system that is tightly coupled in regulating 17beta-HSD3 reaction synthesizing testosterone. A cycle can exist whereby the NADPH produced by 11beta-HSD1 dehydrogenase can drive the reductase activity of 17beta-HSD3 and the NADP+ produced by 17beta-HSD3 and other enzymes involved in testosterone biosynthesis can drive the dehydrogenase activity of 11beta-HSD1
i.e. 4-androsten-17beta-ol-3-one
-
?
corticosterone + NAD+
11-dehydrocorticosterone + NADH + H+
corticosterone + NADP+
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
11-dehydrocorticosterone + NADPH + H+
corticosterone + NADPH + H+
corticosterol + NADP+
-
-
-
?
cortisol + NAD+
cortisone + NADH
isozyme 11beta-HSD2 catalyzes the reverse reaction with cofactor NAD+
-
-
ir
cortisol + NAD+
cortisone + NADH + H+
cortisol + NADP+
cortisone + NADPH
cortisol + NADP+
cortisone + NADPH + H+
cortisone + NAD(P)H
cortisol + NAD(P)+
cortisone + NADH + H+
cortisol + NAD+
cortisone + NADPH + H+
cortisol + NADP+
dehydrocorticosterone + NADPH
corticosterone + NADP+
-
isozyme 11beta-HSD1, 11beta-hydroxysteroid dehydrogenase activity, EC 1.1.1.146
-
-
r
oracin + NADPH + H+
dihydrooracin + NADP+
-
a cytostatic drug, isozyme 11beta-HSD1, carbonyl reductase activity, EC 1.1.1.184, stereochemical ratio of 3:1 for R:S enantiomers of the pro-chiral carbonyl centre of oracin, inactivation of the anti-cancer drug
-
-
r
pregn-4-ene-3,11,20-trione + NADPH
11beta-hydroxy-pregn-4-ene-3,20-dione + NADP+
additional information
?
-
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
-
isozyme 11beta-HSD1
-
-
?
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
-
isozyme 11beta-HSD1
-
-
?
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
-
-
-
-
r
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
-
predominantly a reductase in vivo
-
-
r
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
-
primarly a reductase in vivo
-
-
r
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
-
isozyme 11beta-HSD1, biological activation of the glucocorticoid
-
-
?
11alpha-hydroxy-pregn-4-ene-3,20-dione + ?
pregn-4-ene-3,11,20-trione + ?
-
2fold higher activity than for cortisol
-
?
11alpha-hydroxy-pregn-4-ene-3,20-dione + ?
pregn-4-ene-3,11,20-trione + ?
-
i.e. 11alpha-hydroxy progesterone
-
?
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
-
i.e. cortisol
i.e. cortisol
-
r
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
-
i.e. cortisol
i.e. cortisone
?
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
-
i.e. cortisol
i.e. cortisone
ir
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
-
i.e. cortisol
i.e. cortisone
ir
11beta,17beta-dihydroxyandrost-4-ene-3-one + ?
17beta-hydroxyandrost-4-ene-3,11-dione + ?
-
same activity as for cortisol
-
?
11beta,17beta-dihydroxyandrost-4-ene-3-one + ?
17beta-hydroxyandrost-4-ene-3,11-dione + ?
-
i.e. 11beta-hydroxy-testosterone
-
?
11beta,20alpha-dihydroxypregn-4-ene-3-one + ?
20alpha-hydroxypregn-4-ene-3,11-dione + ?
-
4fold activity than for cortisol
-
?
11beta,20alpha-dihydroxypregn-4-ene-3-one + ?
20alpha-hydroxypregn-4-ene-3,11-dione + ?
-
i.e. 11beta-hydroxy,20-dihydroprogesterone
-
?
11beta,20beta-dihydroxypregn-4-ene-3-one + ?
20beta-hydroxypregn-4-ene-3,11-dione + ?
-
46% of the activity compared to cortisol
-
?
11beta,20beta-dihydroxypregn-4-ene-3-one + ?
20beta-hydroxypregn-4-ene-3,11-dione + ?
-
i.e. 11beta,20beta-dihydroxoprogesterone
-
?
11beta,21-dihydroxypregn-4-en-3,20-dione + ?
11-dehydro,21-hydroxy-pregn-4-en-3,20-dione + ?
-
i.e. corticosterone
-
?
11beta,21-dihydroxypregn-4-en-3,20-dione + ?
11-dehydro,21-hydroxy-pregn-4-en-3,20-dione + ?
-
3fold activity than for cortisol
-
?
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+
-
no enzyme activity in reverse reaction direction
-
ir
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+
-
i.e. corticosterone
-
?
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+
-
i.e. corticosterone
-
ir
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH
-
i.e. cortisone
-
-
r
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH
-
i.e. corticosterone, only oxidative activity
-
-
ir
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH
-
i.e. corticosterone, significant higher rate of conversion for 11-beta-HSD2 than for 11-beta-HSD1
-
-
ir
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH
-
in aldosterone-insensitive Pars Recta
-
-
r
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH
-
i.e. corticosterone, 5.5times higher affinity for 11-dehydrocorticosterone than for cortisone, 24times higher affinity of corticosterone to 11-dehydrogenase than of cortisol, predominant reductive activity
-
-
r
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+
-
-
-
?
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+
-
-
-
?
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+
dogfish
-
-
-
?
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+
-
-
-
?
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+
-
-
-
?
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+
-
-
-
?
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+
-
-
-
r
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+
-
-
-
r
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+
-
i.e. corticosterone isoform 11beta-HSD1
-
r
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+
-
10-20fold faster than cortisol oxidation
-
?
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+
-
5.5times higher affinity for 11-dehydrocorticosterone than for cortisone, 24times higher affinity of corticosterone to 11-dehydrogenase than of cortisol, predominant reductive activity
-
r
11beta-hydroxy-pregn-4-ene-3,20-dione + ?
pregn-4-ene-3,11,20-trione + ?
-
highest activity
-
?
11beta-hydroxy-pregn-4-ene-3,20-dione + ?
pregn-4-ene-3,11,20-trione + ?
-
i.e. 11beta-hydroxy progesterone
-
?
11beta-hydroxyandrost-4-ene-3,17-dione + ?
androst-4-ene-3,11,17-trione + ?
-
i.e. 11beta-hydroxy-androstenedione
-
?
11beta-hydroxyandrost-4-ene-3,17-dione + ?
androst-4-ene-3,11,17-trione + ?
-
38% of the activity compared to cortisol
-
?
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
-
i.e. cortisone
i.e. cortisol
?
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
-
i.e. cortisone
i.e. cortisol
?
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
-
type-1 enzyme works as a reductase, generating active cortisol, type-2 enzyme works exclusively as a dehydrogenase by inactivating glucocorticoids
i.e. cortisol
r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
-
i.e. cortisone
i.e. cortisol
r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
-
implicated in the pathogenesis of insulin resistance and obesity
i.e. cortisol
r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
-
type-1 enzyme works as a reductase, generating active cortisol, type-2 enzyme works exclusively as a dehydrogenase by inactivating glucocorticoids
i.e. cortisol
r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
-
i.e. cortisone
i.e. cortisol
r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
-
i.e. cortisone
i.e. cortisol
r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
-
i.e. cortisone
i.e. cortisol
r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
-
type-1 enzyme works as a reductase, generating active cortisol, type-2 enzyme works exclusively as a dehydrogenase by inactivating glucocorticoids
i.e. cortisol
r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
-
i.e. cortisone
i.e. cortisol
r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
-
type-1 enzyme works as a reductase, generating active cortisol, type-2 enzyme works exclusively as a dehydrogenase by inactivating glucocorticoids
i.e. cortisol
r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
-
i.e. cortisone
i.e. cortisol
?
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
-
i.e. cortisone
i.e. cortisol
r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
-
i.e. cortisone, 5.5 times lower affinity than for 11-dehydrocorticosterone
i.e. cortisol
-
r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
-
i.e. cortisone, stable dehydrogenase activity, unstable oxidoreductase activity
i.e. cortisol
-
?
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
-
5.5 times lower affinity than for 11-dehydrocorticosterone
i.e. cortisol
r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
-
i.e. cortisone
i.e. cortisol
?
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
-
i.e. cortisone
i.e. cortisol
r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
-
i.e. cortisone
i.e. cortisol
r
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
-
-
i.e. corticosterone
?
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
-
-
i.e. corticosterone
?
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
-
-
i.e. corticosterone
?
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
-
-
i.e. corticosterone
?
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
-
-
i.e. corticosterone
ir
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
-
10times higher activity than for cortisol
i.e. corticosterone
ir
7beta-hydroxycholesterol + NADP+
7-oxocholesterol + NADPH
-
-
-
-
r
7beta-hydroxycholesterol + NADP+
7-oxocholesterol + NADPH
-
-
-
r
7beta-hydroxycholesterol + NADP+
7-oxocholesterol + NADPH
-
-
-
-
r
corticosterone + NAD+
11-dehydrocorticosterone + NADH + H+
-
-
-
?
corticosterone + NAD+
11-dehydrocorticosterone + NADH + H+
A0A1B0GWP2
-
-
-
?
corticosterone + NADP+
11-dehydrocorticosterone + NADPH
-
-
-
-
?
corticosterone + NADP+
11-dehydrocorticosterone + NADPH
-
-
-
-
ir
corticosterone + NADP+
11-dehydrocorticosterone + NADPH
-
-
-
-
r
corticosterone + NADP+
11-dehydrocorticosterone + NADPH
-
-
-
r
corticosterone + NADP+
11-dehydrocorticosterone + NADPH
-
-
-
-
ir
corticosterone + NADP+
11-dehydrocorticosterone + NADPH
-
acts as a reductase in vivo
-
-
r
corticosterone + NADP+
11-dehydrocorticosterone + NADPH
-
-
-
-
?
corticosterone + NADP+
11-dehydrocorticosterone + NADPH
-
-
-
-
r
corticosterone + NADP+
11-dehydrocorticosterone + NADPH + H+
-
-
-
?
corticosterone + NADP+
11-dehydrocorticosterone + NADPH + H+
-
bidirectional in vitro, believed to predominantly function as an oxidoreductase in vivo
-
-
r
cortisol + NAD+
cortisone + NADH + H+
-
-
-
?
cortisol + NAD+
cortisone + NADH + H+
-
-
-
?
cortisol + NAD+
cortisone + NADH + H+
the reaction is catalyzed by isoform 11beta-HSD2
-
-
?
cortisol + NAD+
cortisone + NADH + H+
the reaction is catalyzed by isoform 11beta-HSD2
-
-
?
cortisol + NAD+
cortisone + NADH + H+
-
-
-
?
cortisol + NAD+
cortisone + NADH + H+
-
-
-
?
cortisol + NAD+
cortisone + NADH + H+
A0A1B0GWP2
-
-
-
?
cortisol + NADP+
cortisone + NADPH
-
-
-
r
cortisol + NADP+
cortisone + NADPH
-
inactivation of the biologically active glucocorticoid
-
-
r
cortisol + NADP+
cortisone + NADPH
-
-
-
-
?
cortisol + NADP+
cortisone + NADPH + H+
-
-
-
-
?
cortisol + NADP+
cortisone + NADPH + H+
-
-
-
-
r
cortisol + NADP+
cortisone + NADPH + H+
-
-
-
?
cortisol + NADP+
cortisone + NADPH + H+
-
-
-
?
cortisol + NADP+
cortisone + NADPH + H+
-
-
-
r
cortisol + NADP+
cortisone + NADPH + H+
-
substrate for isoforms 11betaHSD1 and 11betaHSD2
-
-
?
cortisol + NADP+
cortisone + NADPH + H+
-
-
-
-
?
cortisol + NADP+
cortisone + NADPH + H+
-
-
-
r
cortisol + NADP+
cortisone + NADPH + H+
-
-
-
-
?
cortisone + NAD(P)H
cortisol + NAD(P)+
-
-
-
-
r
cortisone + NAD(P)H
cortisol + NAD(P)+
-
-
-
-
r
cortisone + NADH + H+
cortisol + NAD+
Q6P0H9
-
-
-
?
cortisone + NADH + H+
cortisol + NAD+
-
-
-
?
cortisone + NADH + H+
cortisol + NAD+
-
-
-
?
cortisone + NADH + H+
cortisol + NAD+
-
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
-
pathway overview
-
-
ir
cortisone + NADPH + H+
cortisol + NADP+
-
-
-
-
r
cortisone + NADPH + H+
cortisol + NADP+
isozyme 11beta-HSD1 catalyzes the forward reaction with cofactor NADPH
-
-
ir
cortisone + NADPH + H+
cortisol + NADP+
-
liver, kidney 11beta-HSD1
-
-
r
cortisone + NADPH + H+
cortisol + NADP+
-
-
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
-
-
-
-
r
cortisone + NADPH + H+
cortisol + NADP+
-
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
-
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
-
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
-
-
-
ir
cortisone + NADPH + H+
cortisol + NADP+
-
11betaHSD1 acts as a reductase in vivo
-
-
r
cortisone + NADPH + H+
cortisol + NADP+
-
bidirectional in vitro, believed to predominantly function as an oxidoreductase in vivo
-
-
r
cortisone + NADPH + H+
cortisol + NADP+
-
bidirectional reaction in vitro, it is suggested that in vivo 11beta-HSD 1 functions primarly as reductase, reactivating inert 11-oxo glucocorticoids to the corresponding receptor-active 11beta-hydroxy forms
-
-
r
cortisone + NADPH + H+
cortisol + NADP+
-
primarly a reductase in vivo
-
-
r
cortisone + NADPH + H+
cortisol + NADP+
-
biological transformation of inactive cortisone to active cortisol
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
-
isozyme 11beta-HSD1
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
-
isozyme 11beta-HSD1
-
-
r
cortisone + NADPH + H+
cortisol + NADP+
isozyme 11beta-HSD1
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
-
isozyme 11beta-HSD1
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
-
isozyme 11beta-HSD1 catalyzes the forward reaction with cofactor NADPH
-
-
ir
cortisone + NADPH + H+
cortisol + NADP+
-
isozyme 11beta-HSD1, 11beta-hydroxysteroid dehydrogenase activity, EC 1.1.1.146
-
-
r
cortisone + NADPH + H+
cortisol + NADP+
-
isozyme 11beta-HSD1, the enzyme seems not to be involved in free fatty acid-induced insulin resistance, overview
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
-
substrate for isoform 11betaHSD1 only
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
preferred direction of reaction
-
-
r
cortisone + NADPH + H+
cortisol + NADP+
the reaction is catalyzed by isoform 11beta-HSD1
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
the reaction is catalyzed by isoform 11beta-HSD1
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
-
-
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
-
-
-
-
r
cortisone + NADPH + H+
cortisol + NADP+
-
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
-
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
-
isozyme 11beta-HSD1
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
isozyme 11beta-HSD1 catalyzes the forward reaction with cofactor NADPH
-
-
ir
cortisone + NADPH + H+
cortisol + NADP+
-
-
-
r
cortisone + NADPH + H+
cortisol + NADP+
-
-
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
-
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
-
isozyme 11beta-HSD1 might play an important role in the metabolic syndrome
-
-
r
cortisone + NADPH + H+
cortisol + NADP+
-
isozyme 11beta-HSD1 prefers the reduction of cortisone
-
-
r
cortisone + NADPH + H+
cortisol + NADP+
-
isozyme 11beta-HSD1, biological activation of the glucocorticoid
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
isozyme 11beta-HSD1 catalyzes the forward reaction with cofactor NADPH
-
-
ir
pregn-4-ene-3,11,20-trione + NADPH
11beta-hydroxy-pregn-4-ene-3,20-dione + NADP+
-
-
-
?
pregn-4-ene-3,11,20-trione + NADPH
11beta-hydroxy-pregn-4-ene-3,20-dione + NADP+
-
-
-
?
pregn-4-ene-3,11,20-trione + NADPH
11beta-hydroxy-pregn-4-ene-3,20-dione + NADP+
-
-
-
?
pregn-4-ene-3,11,20-trione + NADPH
11beta-hydroxy-pregn-4-ene-3,20-dione + NADP+
-
-
-
?
additional information
?
-
-
high local cortisol concentrations generated via the 11beta-HSD1 pathway within the liver likely contribute to the regulation of hepatic glucose, fat, and protein metabolism
-
-
?
additional information
?
-
-
the enzyme activates pro-glucocorticoid hormones in a tissue-specific manner
-
-
?
additional information
?
-
-
enzyme inhibition affects the glucocorticoid- and dexamethasone-mediated regulation of surfactant protein A metabolism, overview
-
-
?
additional information
?
-
isozyme 11beta-HSD1 is essential for local activation of glucocorticoid receptors, compartimentalization is important for its regulation by hexose-6-phosphate dehydrogenase, metabolic regulation, overview
-
-
?
additional information
?
-
-
isozyme 11beta-HSD1-driven cortisone reactivation regulates plasminogen activator inhibitor type 1, PAI-1, in adipose tissue of obese women
-
-
?
additional information
?
-
the enzyme activates pro-glucocorticoid hormones in a tissue-specific manner
-
-
?
additional information
?
-
-
the enzyme activates pro-glucocorticoid hormones in a tissue-specific manner
-
-
?
additional information
?
-
-
the enzyme interconvertes 11-oxo-glucocorticoids to their 11-hydroxy metabolites, reaction of EC 1.1.1.146, but is also active as carbonyl reductase, EC 1.1.1.184, in detoxification of xenobiotic carbonyl compounds reducing them to alcohols that are easier to conjugate and eliminate
-
-
?
additional information
?
-
-
local amplification of glucocorticoids by isozyme 11beta-HSD1 promotes macrophage phagocytosis of apoptotic leukocytes
-
-
?
additional information
?
-
-
the enzyme activates pro-glucocorticoid hormones in a tissue-specific manner
-
-
?
additional information
?
-
-
isoform 11beta-HSD1 is involved in mediation of cortisol bioavailability in the choroid plexus
-
-
?
additional information
?
-
-
effects of hypertension on cardiac steroid metabolism, overview
-
-
?
additional information
?
-
-
estradiol has a regulatory function on the isozymes in the liver, isozyme 11beta-HSD1 expression is about 30% reduced in castrated male rats, while expression of isozyme 11beta-HSD2 is increased, overview
-
-
?
additional information
?
-
-
isozyme 11beta-HSD1 and hexose-6-phosphate dehydrogenase are co-localized in the hepatic endoplasmic reticulum and act in close cooperation in generation of cofactors for each other, functional coupling, overview
-
-
?
additional information
?
-
-
isozyme 11beta-HSD1 is regulated by the pentose phosphate pathway flux, overview
-
-
?
additional information
?
-
-
the enzyme activates pro-glucocorticoid hormones in a tissue-specific manner
-
-
?
additional information
?
-
the enzyme plays a role in control of cortisol and spermatogenesis
-
-
?
additional information
?
-
-
physiological role of 11beta-hydroxysteroid dehydrogenase in limiting any local actions of glucocorticoids within the reproductive tissues
-
-
?