1.1.1.176: 12alpha-hydroxysteroid dehydrogenase

This is an abbreviated version!
For detailed information about 12alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.176

1.1.1.176

bile

synthesis

clostridium

sephadex

7alpha-oh

7alpha-hydroxysteroid

unconjugated

dehydrogenases

7alpha

degradation

Reaction

3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oate

Synonyms

12alpha-HSDH, 12alpha-hydroxy steroid dehydrogenase, CDD59475, dehydrogenase, 12alpha-hydroxy steroid, Elen_2515, NAD+-dependent 12alpha-HSDH, NAD-dependent 12alpha-hydroxysteroid dehydrogenase, NADP+-dependent 12alpha-HSDH, NADP-12alpha-hydroxysteroid dehydrogenase, NADP-dependent 12alpha-hydroxysteroid dehydrogenase

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.176 12alpha-hydroxysteroid dehydrogenase

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Results	in table
4	AA Sequence
6	Application
1	CAS Registry Number
4	Cloned(Commentary)
26	Cofactor
3	General Information
1	General Stability
8	Inhibitors
16	kcat/KM [mM/s]
35	KM Value [mM]
9	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
31	Organism
2	Pathway
18	pH Optimum
1	pH Range
5	Protein Variants
11	Purification (Commentary)
1	Reaction
1	Reaction Type
30	Reference
1	Source Tissue
3	Specific Activity [micromol/min/mg]
6	Storage Stability
132	Substrates and Products (Substrate)
22	Subunits
31	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
6	Temperature Stability [°C]
16	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.1.1.176 - 12alpha-hydroxysteroid dehydrogenase

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12-ketochenodeoxycholic acid + NADH

cholic acid + NAD+

Brevibacterium fuscum

347748

12-oxolithocholic acid + NADH + H+

deoxycholic acid + NAD+

3 entries

12-oxolithocholic acid + NADPH + H+

deoxycholic acid + NADP+

Eggerthella lenta

761221

cholate + NAD+

3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADH + H+

2 entries

cholate + NADP+

3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADPH + H+

3 entries

additional information

2 entries