1.1.1.188: prostaglandin-F synthase

This is an abbreviated version!
For detailed information about prostaglandin-F synthase, go to the full flat file.

Reaction

Synonyms

17beta-hydroxysteroid dehydrogenase type 5, 17betaHSD5, 20alpha-HSD/PGFS, 20alpha-hydroxysteroid dehydrogenase/prostaglandin F-synthase, 9,11-endoperoxidase reductase, AKR1B1, AKR1B3, AKR1B7, AKR1C3, Akr1cl, aldo-keto reductase, aldo-keto reductase 1C3, aldo-ketoreductase 1B1, ALDR1, ALR2, DD1, dihydrodiol dehydrogenase 1, LBRM2904_31.2170, LemaA.00019.a.B1, m-PGFS, More, NADPH-dependent prostaglandin D2 11-keto reductase, P100/11E, PG endoperoxide reductase, PGD 11-ketoreductase, PGD2 11-ketoreductase, PGF, PGF synthase, PGF synthase I, PGF synthase II, PGF2alpha synthase, PGF2alpha-synthase, PGF2alpha-synthetic activity, PGF2S, PGFS, PGFS I, PGFS-I, PGFS-II, PGFSI, PGFSII, PGH 9-,11-endoperoxide reductase, PGH2 9,11-endoperoxidase, PGH2 9,11-endoperoxide reductase, PGH2 9-,11-endoperoxide reductase, prostaglandin 11-keto reductase, prostaglandin 11-ketoreductase, prostaglandin D2 11-ketoreductase, prostaglandin D2-ketoreductase, prostaglandin F synthase, prostaglandin F synthase I, prostaglandin F synthase II, prostaglandin F synthetase, prostaglandin F2alpha synthase, prostaglandin F2alpha-synthase, prostaglandin-D2 11-reductase, prostaglandin-F2alpha synthase, prostamide/PGF synthase, prostamide/prostaglandin F synthase, reductase, 15-hydroxy-11-oxoprostaglandin, synthetase, prostaglandin F2alpha, Tc00.1047053508461.80, Tc00.1047053511287.49, TCDM_00059, TrcrA.00019.a.B1, type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase, vas deferens protein

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.188 prostaglandin-F synthase

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Results	in table
21	Activating Compound
99	AA Sequence
11	Application
1	CAS Registry Number
39	Cloned(Commentary)
60	Cofactor
9	Crystallization (Commentary)
103	Disease/ Diagnostics
18	Expression
41	General Information
2	General Stability
67	IC50 Value
90	Inhibitors
1	kcat/KM [mM/s]
21	Ki Value [mM]
107	KM Value [mM]
38	Localization
6	Metals/Ions
32	Molecular Weight [Da]
47	Natural Substrates/ Products (Substrates)
101	Organism
4	Pathway
60	PDB ID
21	pH Optimum
1	pH Range
33	Protein Variants
23	Purification (Commentary)
5	Reaction
4	Reaction Type
95	Reference
200	Source Tissue
37	Specific Activity [micromol/min/mg]
5	Storage Stability
185	Substrates and Products (Substrate)
16	Subunits
190	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
2	Temperature Range [°C]
2	Temperature Stability [°C]
7	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.1.1.188 - prostaglandin-F synthase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+

(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+

5 entries

(5Z,13E)-(15S)-9alpha,11beta,15-trihydroxyprosta-5,13-dienoate + NADP+

(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+

Homo sapiens

P15121, P42330

-

740999

-

-

?

(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+

2 entries

prostaglandin D2 + NADP+

9alpha,11beta-prostaglandin F2 + NADPH

Homo sapiens

P42330

-

740413

-

-

?

prostaglandin D2 + NADPH + H+

9-alpha,11-beta-prostaglandin F2 + NADP+

Homo sapiens

-

-

699917

-

-

?

prostaglandin D2 + NADPH + H+

9alpha,11alpha-prostaglandin F2alpha + NADP+

Mus musculus

-

-

667422

-

-

?

prostaglandin D2 + NADPH + H+

9alpha,11beta-prostaglandin F2 + NADP+

Mus musculus

-

-

667422

-

-

?

prostaglandin D2 + NADPH + H+

9alpha,11beta-prostaglandin F2alphabeta + NADP+

Homo sapiens

P42330

-

667713

-

-

?

prostaglandin D2 + NADPH + H+

prostaglandin 9alpha,11beta-F2 + NADP+

5 entries

prostaglandin H2 + NADP+

prostaglandin F2alpha + NADPH + H+

5 entries

prostaglandin H2 + NADPH + H+

9alpha,11alpha-prostaglandin F2alpha + NADP+

Homo sapiens

P42330

-

667713

-

-

?

prostaglandin H2 + NADPH + H+

9alpha,11beta-prostaglandin F2 + NADP+

Rattus norvegicus

-

-

655139

-

-

?

prostaglandin H2 + NADPH + H+

prostaglandin D2 + NADP+

4 entries

prostaglandin H2 + NADPH + H+

prostaglandin F2alpha + NADP+

7 entries

additional information

?

-

8 entries

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+

(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+

Homo sapiens

P15121

-

740487, 740999

-

-

?

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+

(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+

Homo sapiens

P42330

-

740999, 740414

-

-

?

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+

(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+

Leishmania major

P22045

-

739821

-

-

?

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+

(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+

Trypanosoma cruzi

Q4DJ07

-

739821

-

-

?

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+

(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+

Trypanosoma cruzi CL Brener

Q4DJ07

-

739821

-

-

?

(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+

Oryctolagus cuniculus

-

transformation of endogenous prostaglandin D2 to prostaglandin F2alpha

389461, 389462

-

-

?

(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+

Rattus norvegicus

-

prostaglandin F2alpha exhibits contraction of smooth muscles in the uterus, brochus trachea, luteolysis, the initiation of partutition and pain transmission

389445

-

-

?

prostaglandin D2 + NADPH + H+

prostaglandin 9alpha,11beta-F2 + NADP+

Bos taurus

-

-

657211

product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion

-

?

prostaglandin D2 + NADPH + H+

prostaglandin 9alpha,11beta-F2 + NADP+

Homo sapiens

-

-

657211

product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion

-

?

prostaglandin D2 + NADPH + H+

prostaglandin 9alpha,11beta-F2 + NADP+

Oryctolagus cuniculus

-

-

657211

product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion

-

?

prostaglandin D2 + NADPH + H+

prostaglandin 9alpha,11beta-F2 + NADP+

Rattus norvegicus

-

-

657211

product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion

-

?

prostaglandin D2 + NADPH + H+

prostaglandin 9alpha,11beta-F2 + NADP+

Sus scrofa

-

-

657328

-

-

?

prostaglandin H2 + NADP+

prostaglandin F2alpha + NADPH + H+

Bos taurus

P16116

-

741357

-

-

?

prostaglandin H2 + NADP+

prostaglandin F2alpha + NADPH + H+

Canis lupus familiaris

Q5FYA7

-

740130

-

-

?

prostaglandin H2 + NADP+

prostaglandin F2alpha + NADPH + H+

Felis catus

E2IGW3

-

726469

-

-

?

prostaglandin H2 + NADP+

prostaglandin F2alpha + NADPH + H+

Homo sapiens

P15121

-

741012, 741357

-

-

?

prostaglandin H2 + NADP+

prostaglandin F2alpha + NADPH + H+

Homo sapiens

-

-

741357

-

-

?

prostaglandin H2 + NADPH + H+

prostaglandin D2 + NADP+

Bos taurus

-

-

657211

-

-

?

prostaglandin H2 + NADPH + H+

prostaglandin D2 + NADP+

Homo sapiens

-

-

657211

-

-

?

prostaglandin H2 + NADPH + H+

prostaglandin D2 + NADP+

Oryctolagus cuniculus

-

-

657211

-

-

?

prostaglandin H2 + NADPH + H+

prostaglandin D2 + NADP+

Rattus norvegicus

-

-

657211

-

-

?

prostaglandin H2 + NADPH + H+

prostaglandin F2alpha + NADP+

Bos taurus

-

enzyme also shows PGH2 9-,11-endoperoxide reductase activity

657211

-

-

?

prostaglandin H2 + NADPH + H+

prostaglandin F2alpha + NADP+

Homo sapiens

-

-

654851

-

-

?

prostaglandin H2 + NADPH + H+

prostaglandin F2alpha + NADP+

Mus musculus

-

-

654851

-

-

?

prostaglandin H2 + NADPH + H+

prostaglandin F2alpha + NADP+

Ovis aries

-

-

657211

-

-

?

prostaglandin H2 + NADPH + H+

prostaglandin F2alpha + NADP+

Rattus norvegicus

-

-

654851, 655139

-

-

?

prostaglandin H2 + NADPH + H+

prostaglandin F2alpha + NADP+

Sus scrofa

-

-

657328

-

-

?

prostaglandin H2 + NADPH + H+

prostaglandin F2alpha + NADP+

Trypanosoma brucei

-

-

655915, 657211

-

-

?

additional information

?

-

Bos taurus

-

the enzyme is important for the production of lyteolytic prostaglandin F2alpha in the endometrium of cows, regulatory mechanisms, overview

670525

-

-

?

additional information

?

-

Homo sapiens

-

the cytosolic enzyme synergistically interacts with cyclooxygenase 1 and 2, coupling, isozyme PGFS-I interacts predominantly with cyclooxygenase 2, i.e. COX-2

654851

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme has dual activity as PGD2 11-ketoreductase and PGH2 9,11-endoperoxide reductase

667713

-

-

?

additional information

?

-

Homo sapiens

P42330

the enzyme has dual activity as PGD2 11-ketoreductase and PGH2 9,11-endoperoxide reductase

667713

-

-

?

additional information

?

-

Homo sapiens

P42330

AKR1C3 is overexpressed in keloids and mediates the conversion of PGD2 to 9alpha,11beta-PGF2 in keloid and normal fibroblasts

740414

-

-

?

additional information

?

-

Mus musculus

-

coupling ability between cyclooxygenase COX-2 and the prostanoid synthases performing the last stepes in the biosynthesis of prostaglandins PGE2, PGD2, PGF2alpha, and PGI2, regulation, overview, the 20alpha-hydroxysteroid dehydrogenase also shows prostaglandin F synthase activity in the endometrium during luteolysis

667422

-

-

?

additional information

?

-

Mus musculus

-

prostaglandin F synthase and prostaglandin F receptor are involved in the control of testosterone release from Leydig cells and in spermatogenesis via the local pathway and the hypothalamo-hypophysial-testis-pathway

687013

-

-

?

additional information

?

-

Rattus norvegicus

-

enzyme interacts with cyclooxygenase 1 and 2, isozyme PGFS-I interacts predominantly with cyclooxygenase 2, i.e. COX-2

654851

-

-

?