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(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+
(5Z,13E)-(15S)-9alpha,11beta,15-trihydroxyprosta-5,13-dienoate + NADP+
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+
-
-
-
?
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH
(5Z,13E)-(15S)-9alpha,11beta,15-trihydroxyprosta-5,13-dienoate + NADP+
4-nitroacetophenone + NADPH
?
-
high activity
-
-
?
4-nitrobenzaldehyde + NADPH
4-nitrobenzalcohol + NADP+
-
high activity
-
-
?
4-nitrobenzaldehyde + NADPH
4-nitrobenzyl alcohol + NADP+
4-nitrobenzaldehyde + NADPH + H+
(4-nitrophenyl)methanol + NADP+
5beta-androstane-3,17-dione + NADPH
5beta-androstan-3alpha-ol-17-one + NADP+
-
-
-
-
r
5beta-dihydrotestosterone + NADPH
?
-
-
-
-
?
9,10-phenanthrenequinone + NADPH
?
9,10-phenanthrenequinone + NADPH
? + NADP+
-
-
-
?
9,10-phenanthrenequinone + NADPH + H+
?
-
-
-
?
9alpha,11beta-prostaglandin F2 + NADPH + H+
prostaglandin D2 + NADP+
-
-
-
r
androst-4-ene-3,17-dione + NADPH
? + NADP+
-
-
-
?
cyclohexanone + NADPH
cyclohexanol + NADP+
D-xylose + NADPH
?
-
-
-
-
?
daunorubicin + NADPH
?
-
high activity
-
-
?
DL-glyceraldehyde + NADPH
DL-glycerol + NADP+
-
-
-
-
?
duroquinone + NADPH
?
-
-
-
-
?
n-butyraldehyde + NADPH
n-butanol + NADP+
-
-
-
-
?
p-nitroacetophenone + NADPH
?
-
-
-
-
?
prostaglandin A2 + NADPH
?
-
-
-
-
?
prostaglandin D1 + NADPH
?
-
-
-
-
?
prostaglandin D2 + NADP+
9alpha,11beta-prostaglandin F2 + NADPH
-
-
-
?
prostaglandin D2 + NADP+
9alpha,11beta-prostaglandin F2 + NADPH + H+
-
-
-
r
prostaglandin D2 + NADPH + H+
9-alpha,11-beta-prostaglandin F2 + NADP+
-
-
-
-
?
prostaglandin D2 + NADPH + H+
9alpha,11alpha-prostaglandin F2alpha + NADP+
prostaglandin D2 + NADPH + H+
9alpha,11beta-prostaglandin F2 + NADP+
prostaglandin D2 + NADPH + H+
9alpha,11beta-prostaglandin F2alpha + NADP+
-
-
-
r
prostaglandin D2 + NADPH + H+
9alpha,11beta-prostaglandin F2alphabeta + NADP+
-
-
-
?
prostaglandin D2 + NADPH + H+
prostaglandin 9alpha,11beta-F2 + NADP+
prostaglandin D2 + NADPH + H+
prostaglandin F2alpha + NADP+
-
-
-
?
prostaglandin D2 ethanolamide + NADPH
prostaglandin 9alpha,11beta-F2 ethanolamide + NADP+
i.e. prostamide D2
i.e. 91lpha,11beta-prostamide F2
-
?
prostaglandin D3 + NADPH
?
-
-
-
-
?
prostaglandin H2 + NADP+
prostaglandin F2alpha + NADPH + H+
prostaglandin H2 + NADPH + H+
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
prostaglandin H2 + NADPH + H+
9alpha,11alpha-prostaglandin F2alpha + NADP+
prostaglandin H2 + NADPH + H+
9alpha,11beta-prostaglandin F2 + NADP+
prostaglandin H2 + NADPH + H+
prostaglandin 9alpha,11beta-F2 + NADP+
-
-
-
?
prostaglandin H2 + NADPH + H+
prostaglandin D2 + NADP+
prostaglandin H2 + NADPH + H+
prostaglandin F2alpha + NADP+
prostaglandin I2 + NADPH
?
-
-
-
-
?
prostamide D2 + NADPH + H+
9alpha,11beta-prostamide F2 + NADP+
-
-
-
?
prostamide H2 + NADPH + H+
prostamide F2alpha + NADP+
-
about 70% of prostamide H2 is converted to prostamide F2alpha after 2 min at 37°C
-
-
?
retinal + NADPH
retinol + NADP+
-
-
-
-
?
testosterone + NADPH + H+
?
-
-
-
-
?
ubiquinone-10 + NADPH
?
-
-
-
-
?
additional information
?
-
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+
-
-
-
?
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
-
-
-
?
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
-
-
-
?
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
-
-
-
?
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
-
-
-
ir
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
transformation of endogenous prostaglandin D2 to prostaglandin F2alpha
-
-
?
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
-
-
-
?
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
prostaglandin F2alpha exhibits contraction of smooth muscles in the uterus, brochus trachea, luteolysis, the initiation of partutition and pain transmission
-
-
?
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH
(5Z,13E)-(15S)-9alpha,11beta,15-trihydroxyprosta-5,13-dienoate + NADP+
-
-
-
-
?
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH
(5Z,13E)-(15S)-9alpha,11beta,15-trihydroxyprosta-5,13-dienoate + NADP+
-
-
-
-
?
4-nitrobenzaldehyde + NADPH
4-nitrobenzyl alcohol + NADP+
-
-
-
-
?
4-nitrobenzaldehyde + NADPH
4-nitrobenzyl alcohol + NADP+
-
-
-
-
?
4-nitrobenzaldehyde + NADPH
4-nitrobenzyl alcohol + NADP+
-
-
-
-
?
4-nitrobenzaldehyde + NADPH + H+
(4-nitrophenyl)methanol + NADP+
-
-
-
?
4-nitrobenzaldehyde + NADPH + H+
(4-nitrophenyl)methanol + NADP+
-
-
-
-
?
9,10-phenanthrenequinone + NADPH
?
-
-
-
-
?
9,10-phenanthrenequinone + NADPH
?
-
best substrate
-
-
?
9,10-phenanthrenequinone + NADPH
?
-
i.e. PQ
-
-
?
9,10-phenanthrenequinone + NADPH
?
-
-
-
-
?
9,10-phenanthrenequinone + NADPH
?
-
i.e. PQ
-
-
?
9,10-phenanthrenequinone + NADPH
?
-
i.e. PQ
-
-
?
9,10-phenanthrenequinone + NADPH
?
-
i.e. PQ
-
-
?
9,10-phenanthrenequinone + NADPH
?
-
-
-
-
?
cyclohexanone + NADPH
cyclohexanol + NADP+
-
-
-
-
?
cyclohexanone + NADPH
cyclohexanol + NADP+
-
high activity
-
-
?
hydrindantin + NADPH
?
-
-
-
-
?
hydrindantin + NADPH
?
-
high activity
-
-
?
menadione + NADPH
?
-
-
-
-
?
menadione + NADPH
?
-
high activity
-
-
?
phenylglyoxal + NADPH
?
-
-
-
-
?
phenylglyoxal + NADPH
?
-
high activity
-
-
?
prostaglandin D2 + NADPH + H+
9alpha,11alpha-prostaglandin F2alpha + NADP+
-
reaction via formation of the endoperoxide ethanolamide intermediate prostaglandin H2
-
-
?
prostaglandin D2 + NADPH + H+
9alpha,11alpha-prostaglandin F2alpha + NADP+
-
-
-
-
?
prostaglandin D2 + NADPH + H+
9alpha,11beta-prostaglandin F2 + NADP+
-
-
-
-
?
prostaglandin D2 + NADPH + H+
9alpha,11beta-prostaglandin F2 + NADP+
-
-
-
?
prostaglandin D2 + NADPH + H+
9alpha,11beta-prostaglandin F2 + NADP+
-
-
-
?
prostaglandin D2 + NADPH + H+
9alpha,11beta-prostaglandin F2 + NADP+
-
-
-
-
?
prostaglandin D2 + NADPH + H+
prostaglandin 9alpha,11beta-F2 + NADP+
-
-
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion, i.e. 11-epi PGF2alpha
-
?
prostaglandin D2 + NADPH + H+
prostaglandin 9alpha,11beta-F2 + NADP+
-
amino acid residues Arg27, Arg91, His170, Arg223, and Asn306 are involved in substrate binding
-
-
?
prostaglandin D2 + NADPH + H+
prostaglandin 9alpha,11beta-F2 + NADP+
-
-
-
?
prostaglandin D2 + NADPH + H+
prostaglandin 9alpha,11beta-F2 + NADP+
-
-
-
?
prostaglandin D2 + NADPH + H+
prostaglandin 9alpha,11beta-F2 + NADP+
-
-
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion, i.e. 11-epi PGF2alpha
-
?
prostaglandin D2 + NADPH + H+
prostaglandin 9alpha,11beta-F2 + NADP+
-
-
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion, i.e. 11-epi PGF2alpha
-
?
prostaglandin D2 + NADPH + H+
prostaglandin 9alpha,11beta-F2 + NADP+
-
-
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion, i.e. 11-epi PGF2alpha
-
?
prostaglandin D2 + NADPH + H+
prostaglandin 9alpha,11beta-F2 + NADP+
-
-
-
-
?
prostaglandin H2 + NADP+
prostaglandin F2alpha + NADPH + H+
-
-
-
?
prostaglandin H2 + NADP+
prostaglandin F2alpha + NADPH + H+
-
-
-
?
prostaglandin H2 + NADP+
prostaglandin F2alpha + NADPH + H+
-
-
-
?
prostaglandin H2 + NADP+
prostaglandin F2alpha + NADPH + H+
-
-
-
?
prostaglandin H2 + NADP+
prostaglandin F2alpha + NADPH + H+
-
-
-
-
?
prostaglandin H2 + NADPH + H+
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
-
-
-
?
prostaglandin H2 + NADPH + H+
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
-
-
-
?
prostaglandin H2 + NADPH + H+
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
aldo-keto reductase has prostaglandin F2alpha synthase activity. AKR1B1 is a more efficient prostaglandin F2alpha synthase than AKR1C3
-
-
?
prostaglandin H2 + NADPH + H+
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
aldo-keto reductases AKR1B3 and AKR1B7 have prostaglandin F2alpha synthase activity
-
-
?
prostaglandin H2 + NADPH + H+
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
-
-
-
?
prostaglandin H2 + NADPH + H+
9alpha,11alpha-prostaglandin F2alpha + NADP+
-
-
-
-
?
prostaglandin H2 + NADPH + H+
9alpha,11alpha-prostaglandin F2alpha + NADP+
-
-
-
?
prostaglandin H2 + NADPH + H+
9alpha,11beta-prostaglandin F2 + NADP+
-
-
-
?
prostaglandin H2 + NADPH + H+
9alpha,11beta-prostaglandin F2 + NADP+
-
-
-
-
?
prostaglandin H2 + NADPH + H+
9alpha,11beta-prostaglandin F2 + NADP+
-
-
-
-
?
prostaglandin H2 + NADPH + H+
prostaglandin D2 + NADP+
-
-
-
-
?
prostaglandin H2 + NADPH + H+
prostaglandin D2 + NADP+
-
-
-
-
?
prostaglandin H2 + NADPH + H+
prostaglandin D2 + NADP+
-
-
-
-
?
prostaglandin H2 + NADPH + H+
prostaglandin D2 + NADP+
-
-
-
-
?
prostaglandin H2 + NADPH + H+
prostaglandin F2alpha + NADP+
-
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
-
-
?
prostaglandin H2 + NADPH + H+
prostaglandin F2alpha + NADP+
-
His170 is involved in binding, and Asn306 is critical for catalytic activity
-
-
?
prostaglandin H2 + NADPH + H+
prostaglandin F2alpha + NADP+
-
-
-
-
r
prostaglandin H2 + NADPH + H+
prostaglandin F2alpha + NADP+
-
-
-
?
prostaglandin H2 + NADPH + H+
prostaglandin F2alpha + NADP+
-
-
-
-
?
prostaglandin H2 + NADPH + H+
prostaglandin F2alpha + NADP+
-
-
-
?
prostaglandin H2 + NADPH + H+
prostaglandin F2alpha + NADP+
-
-
-
-
?
prostaglandin H2 + NADPH + H+
prostaglandin F2alpha + NADP+
-
-
-
?
prostaglandin H2 + NADPH + H+
prostaglandin F2alpha + NADP+
-
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
-
-
?
prostaglandin H2 + NADPH + H+
prostaglandin F2alpha + NADP+
-
-
-
-
?
prostaglandin H2 + NADPH + H+
prostaglandin F2alpha + NADP+
-
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
-
-
?
prostaglandin H2 + NADPH + H+
prostaglandin F2alpha + NADP+
-
-
-
-
?
prostaglandin H2 + NADPH + H+
prostaglandin F2alpha + NADP+
-
-
-
-
?
prostaglandin H2 + NADPH + H+
prostaglandin F2alpha + NADP+
-
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
-
-
?
prostaglandin H2 + NADPH + H+
prostaglandin F2alpha + NADP+
-
-
-
-
?
prostaglandin H2 + NADPH + H+
prostaglandin F2alpha + NADP+
-
-
-
?
prostaglandin H2 + NADPH + H+
prostaglandin F2alpha + NADP+
-
-
-
-
?
prostaglandin H2 + NADPH + H+
prostaglandin F2alpha + NADP+
-
-
no stereochemic determination/identification of the product
-
?
additional information
?
-
-
two different active sites, one for the endoperoxide group of prostaglandin H2 and the other one for the keto group of prostaglandin D2 and other carbonyl compounds
-
-
?
additional information
?
-
-
two different active sites, one for the endoperoxide group of prostaglandin H2 and the other one for the keto group of prostaglandin D2 and other carbonyl compounds
-
-
?
additional information
?
-
-
two different active sites, one for the endoperoxide group of prostaglandin H2 and the other one for the keto group of prostaglandin D2 and other carbonyl compounds
-
-
?
additional information
?
-
-
two different active sites, one for the endoperoxide group of prostaglandin H2 and the other one for the keto group of prostaglandin D2 and other carbonyl compounds
-
-
?
additional information
?
-
-
the enzyme is important for the production of lyteolytic prostaglandin F2alpha in the endometrium of cows, regulatory mechanisms, overview
-
-
?
additional information
?
-
-
the liver-type isozyme possesses two catalytic centres and a broad substrate specificity, D-xylose is a poor substrate, no activity with prostaglandin A1, prostaglandin B2, prostaglandin E2, 4-carboxybenzaldehyde, testosterone, 2,6-dichloroindophenol, D-glucose, D-glucuronic acid, and potassium ferricyanide, overview, the enzyme also exhibits aldose reductase, EC 1.1.1.21, and alcohol dehydrogenase, EC 1.1.1.1, activities, respectively
-
-
?
additional information
?
-
PGFS activity of the recombinant proteins is evaluated using an assay based on in situ generation of the precursor of prostaglandin PGH2 biosynthesis. PGF2alpha is measured by ELISA. Comparisons of PGFS activity of recombinant bovine and human endometrial AKRs, overview
-
-
?
additional information
?
-
-
PGFS activity of the recombinant proteins is evaluated using an assay based on in situ generation of the precursor of prostaglandin PGH2 biosynthesis. PGF2alpha is measured by ELISA. Comparisons of PGFS activity of recombinant bovine and human endometrial AKRs, overview
-
-
?
additional information
?
-
-
no activity with prostaglandin E2
-
-
?
additional information
?
-
no activity towards prostaglandin E2 synthesis
-
-
?
additional information
?
-
-
no activity towards prostaglandin E2 synthesis
-
-
?
additional information
?
-
-
the cytosolic enzyme synergistically interacts with cyclooxygenase 1 and 2, coupling, isozyme PGFS-I interacts predominantly with cyclooxygenase 2, i.e. COX-2
-
-
?
additional information
?
-
acive site structure, enzyme also shows 3alpha-hydroxysteroid dehydrogenase type II activity
-
-
?
additional information
?
-
-
substrate and product detection by liquid chromatographic-electrospray ionization-mass spectrometry
-
-
?
additional information
?
-
substrate and product detection by liquid chromatographic-electrospray ionization-mass spectrometry
-
-
?
additional information
?
-
Y55 and H117 are involved in catalysis, enzyme also shows 3alpha-hydroxysteroid dehydrogenase type II activity
-
-
?
additional information
?
-
-
Y55 and H117 are involved in catalysis, enzyme also shows 3alpha-hydroxysteroid dehydrogenase type II activity
-
-
?
additional information
?
-
-
the enzyme has dual activity as PGD2 11-ketoreductase and PGH2 9,11-endoperoxide reductase
-
-
?
additional information
?
-
the enzyme has dual activity as PGD2 11-ketoreductase and PGH2 9,11-endoperoxide reductase
-
-
?
additional information
?
-
-
PGFS does not catalyze the reduction of prostaglandin E2
-
-
?
additional information
?
-
PGFS does not catalyze the reduction of prostaglandin E2
-
-
?
additional information
?
-
in the absence of NADPH or NADP+, enzyme catalyzes the isomerization of prostaglandin H2 to prostaglandin D2 with a Km value of 0.023 mM. This activity of AKR1B1 increases with increasing pH, with an optimum of pH 8.5. Residue His110 acts as a base in concert with Asp43 and Lys77 and as an acid to generate PGD2 and PGF2a in the absence of NADPH or NADP+ and in the presence of NADPH, respectively
-
-
?
additional information
?
-
-
in the absence of NADPH or NADP+, enzyme catalyzes the isomerization of prostaglandin H2 to prostaglandin D2 with a Km value of 0.023 mM. This activity of AKR1B1 increases with increasing pH, with an optimum of pH 8.5. Residue His110 acts as a base in concert with Asp43 and Lys77 and as an acid to generate PGD2 and PGF2a in the absence of NADPH or NADP+ and in the presence of NADPH, respectively
-
-
?
additional information
?
-
AKR1C3 is overexpressed in keloids and mediates the conversion of PGD2 to 9alpha,11beta-PGF2 in keloid and normal fibroblasts
-
-
?
additional information
?
-
PGFS activity of the recombinant proteins is evaluated using an assay based on in situ generation of the precursor of prostaglandin PGH2 biosynthesis. PGF2alpha is measured by ELISA. Comparisons of PGFS activity of recombinant bovine and human endometrial AKRs, overview
-
-
?
additional information
?
-
-
PGFS activity of the recombinant proteins is evaluated using an assay based on in situ generation of the precursor of prostaglandin PGH2 biosynthesis. PGF2alpha is measured by ELISA. Comparisons of PGFS activity of recombinant bovine and human endometrial AKRs, overview
-
-
?
additional information
?
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coupling ability between cyclooxygenase COX-2 and the prostanoid synthases performing the last stepes in the biosynthesis of prostaglandins PGE2, PGD2, PGF2alpha, and PGI2, regulation, overview, the 20alpha-hydroxysteroid dehydrogenase also shows prostaglandin F synthase activity in the endometrium during luteolysis
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prostaglandin F synthase and prostaglandin F receptor are involved in the control of testosterone release from Leydig cells and in spermatogenesis via the local pathway and the hypothalamo-hypophysial-testis-pathway
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no activity with prostaglandin D2 and prostaglandin E2
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in the absence of NADPH or NADP+, enzyme catalyzes the isomerization of prostaglandin H2 to prostaglandin D2 with a Km value of 0.018 mM. This activity activity of AKR1B1 increases with increasing pH, with an optimum of pH 8.5. Residue His110 acts as a base in concert with Asp43 and Lys77 and as an acid to generate PGD2 and PGF2a in the absence of NADPH or NADP+ and in the presence of NADPH, respectively
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enzyme shows no prostaglandin D2 11-ketoreductase activity, and no glutathione S-transferase activity, although it is similar to the glutathione S-transferase
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enzyme interacts with cyclooxygenase 1 and 2, isozyme PGFS-I interacts predominantly with cyclooxygenase 2, i.e. COX-2
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enzyme does not reduce prostaglandins D2 and E2
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enzyme does not reduce prostaglandins D2 and E2
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