1.1.1.19: glucuronate reductase
This is an abbreviated version!
For detailed information about glucuronate reductase, go to the full flat file.
Word Map on EC 1.1.1.19
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1.1.1.19
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aldo-keto
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aldose
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sorbinil
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akr1b1s
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o-quinones
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alrestatin
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1.1.1.21
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daunorubicinol
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trans-dihydrodiols
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statil
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akr7a2
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dl-glyceraldehyde
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3alpha-hydroxysteroid
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diol-epoxide
- 1.1.1.19
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aldo-keto
- aldose
- sorbinil
- akr1b1s
- o-quinones
- alrestatin
-
1.1.1.21
- daunorubicinol
-
trans-dihydrodiols
- statil
-
akr7a2
- dl-glyceraldehyde
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3alpha-hydroxysteroid
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diol-epoxide
Reaction
Synonyms
AKR1A1, aldehyde reductase, aldehyde reductase II, ALR1, D-glucuronate dehydrogenase, D-glucuronate reductase, D-glucuronic reductase, galacturonate oxidoreductase, hexonate dehydrogenase, L-glucuronate reductase, L-gulonate NAD-3-oxidoreductase, L-hexonate:NADP dehydrogenase, More, NADP-L-gulonate dehydrogenase, PcGOR, TPN l-hexonate dehydrogenase, TPN-L-gulonate dehydrogenase
ECTree
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Inhibitors
Inhibitors on EC 1.1.1.19 - glucuronate reductase
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D-galacturonate
reaction with galacturonate displays marked substrate inhibition
L-gulonate
competitive inhibitors in reaction with D-glucuronate
L-gulono-1,4-lactone
competitive inhibitors in reaction with D-glucuronate
2-mercaptoethanol
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preincubation of gamma-hydroxybutyrate reductase revealed no inhibitory effect
dithiothreitol
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preincubation of gamma-hydroxybutyrate reductase revealed no inhibitory effect
N-ethylmaleimide
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no exact differentiation between organisms in the reference
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no exact differentiation between organisms in the reference
p-chloromercuribenzoate
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no exact differentiation between organisms in the reference
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potent inhibitors, i.e. carboxylic and sulfonic acids, bind weakly to the free enzyme but strongly to the enzyme-NADP+-binary complex
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additional information
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synthesis and evaluation of acetic acid derivatives of [1,2,4]triazino[4,3-a]benzimidazole, the compounds do not inhibit aldehyde reductase, overview
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