1.1.1.213: 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
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For detailed information about 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific), go to the full flat file.
Word Map on EC 1.1.1.213
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1.1.1.213
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aldo-keto
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androgen
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5alpha-reductase
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polycyclic
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17beta-hydroxysteroid
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5alpha-dihydrotestosterone
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alpha-hydroxysteroids
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dihydrotestosterone
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androsterone
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17beta-hsd
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trans-dihydrodiols
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hydroxysteroids
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20alpha-hydroxysteroid
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5alpha-dht
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neurosteroids
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allopregnanolone
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20alpha-hsds
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akr1c9
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3alpha-diol
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o-quinones
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5alpha-androstane-3alpha,17beta-diol
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3alpha-androstanediol
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i-babp
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1.1.1.50
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testosteroni
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17beta
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5alpha-reduced
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alicyclic
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5alpha-dihydroprogesterone
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20alpha-hydroxyprogesterone
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neurosteroidogenic
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drug development
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diagnostics
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medicine
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synthesis
- 1.1.1.213
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aldo-keto
- androgen
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5alpha-reductase
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polycyclic
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17beta-hydroxysteroid
- 5alpha-dihydrotestosterone
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alpha-hydroxysteroids
- dihydrotestosterone
- androsterone
- 17beta-hsd
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trans-dihydrodiols
- hydroxysteroids
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20alpha-hydroxysteroid
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5alpha-dht
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neurosteroids
- allopregnanolone
- 20alpha-hsds
- akr1c9
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3alpha-diol
- o-quinones
- 5alpha-androstane-3alpha,17beta-diol
- 3alpha-androstanediol
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i-babp
-
1.1.1.50
- testosteroni
-
17beta
-
5alpha-reduced
-
alicyclic
- 5alpha-dihydroprogesterone
- 20alpha-hydroxyprogesterone
-
neurosteroidogenic
- drug development
- diagnostics
- medicine
- synthesis
Reaction
Synonyms
17beta-HSD type 5, 17beta-hydroxysteroid dehydrogenase type 5, 3-alpha hydroxysteroid oxidoreductase, 3-alpha-HSO, 3alpha-HSD, 3alpha-HSD type 2, 3alpha-HSD type 3, 3alpha-HSD/CR, 3alpha-HSD3, 3alpha-HSDH, 3alpha-HSOR, 3alpha-hydroxysteroid dehydrogenase, 3alpha-hydroxysteroid dehydrogenase (B-specific), 3alpha-hydroxysteroid dehydrogenase type 2, 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase, 3alpha-hydroxysteroid oxido-reductase, 3alpha-hydroxysteroid oxidoreductase, 3alpha-hydroxysteroid:NAD(P) oxidoreductase, 3alphaHSD, A-specific 3alpha-hydroxysteroid dehydrogenase, AKR1C17, AKR1C2, AKR1C3, AKR1C4, AKR1C9, alpha-HSD/CR, B-specific 3alpha-hydroxysteroid dehydrogenase, bile acid-binding protein, CDD59474, DD2, dihydrodiol dehydrogenase, HSDH, More, NAD+-dependent 3alpha-HSD, NADP(H)-dependent 3alpha-HSD, type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase, type 3 3-alpha-hydroxysteroid dehydrogenase, type 3 3alpha-HSD, type 3 3alpha-hydroxysteroid dehydrogenase, type 5 beta-hydroxysteroid dehydrogenase
ECTree
1.1.1.213 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)Advanced search results
results (
results (Source Tissue
Source Tissue on EC 1.1.1.213 - 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
high expression and activity in astrocytes of glaucomatous optic nerve head
uniform, diffuse, and strong expression of isoform AKR1C3 in normal endometrial epithelium but not in endometrial stromal cells. The expression of AKR1C3 is reduced in both hyperplastic and carcinomatous endometrial epithelium
uniform, diffuse, and strong expression of isoform AKR1C3 in normal endometrial epithelium but not in endometrial stromal cells. The expression of AKR1C3 is reduced in both hyperplastic and carcinomatous endometrial epithelium
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positive AKR1C3 immunoreactivity is extensively present in both adenocarcinoma and squamous cell carcinoma arising from the lung and the gastroesophageal junction
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positive AKR1C3 immunoreactivity is extensively present in both adenocarcinoma and squamous cell carcinoma arising from the lung and the gastroesophageal junction
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strong isoform AKR1C3 immunoreactivity in columnar epithelium but only weak immunoreactivity in squamous epithelium of the gastrointestinal junction
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strong isoform AKR1C3 immunoreactivity in bronchial epithelium but not in bronchial glands or alveolar pneumocytes
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positive AKR1C3 immunoreactivity is extensively present in both adenocarcinoma and squamous cell carcinoma arising from the lung and the gastroesophageal junction
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positive AKR1C3 immunoreactivity is extensively present in both adenocarcinoma and squamous cell carcinoma arising from the lung and the gastroesophageal junction
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6fold higher expression level in female than in male pituitary
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lumbar, of naive, sham-operated and neuropathic rats, enzyme expression analysis and cellular distribution in neurons and glial cells, immunohistochemic analysis, overview
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positive AKR1C3 immunoreactivity is extensively present in both adenocarcinoma and squamous cell carcinoma arising from the lung and the gastroesophageal junction
additional information
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the urothelial epithelium lining the renal pelvis is strongly immunoreactive, but stromal cells in the underlying supporting connective tissue are negative
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only a small number of epithelial cells are immunoreactive with both nuclear and cytoplasmic reactivity
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no activity in the stromal cells or endothelial cells, but weak immunoreactivity in the epididymal epithelial cells
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in renal cortex, endothelial cells of the glomeruli lack immunoreactivity for AKR1C3, but the Bowmans capsule and mesangial cells are strongly reactive, as well as larger epithelial cells of the medulla, overview
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specific expression of AKR1C17, two enzymes are expressed more highly in renal cortex than in the medulla
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in primary prostate stromal cells, co-localization with RODH like 3alpha/17beta-HSD, EC 1.1.1.239
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epithelial cells, but not the stromal cells or endothelial cells
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in Leydig cells, but no or poor activity in germ cells and Sertoli cells
additional information
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tissue distribution of AKR1C3, immunohistochemic analysis, overview
additional information
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no isoform AKR1C3 immunoreactivity in bronchial glands or alveolar pneumocytes and small cell carcinoma of the lung, only weak immunoreactivity in squamous epithelium of the gastrointestinal junction
additional information
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the androgen-inactivating enzyme is selectively expressed in female tissue, while it is mostly absent in male tissue, tissue distribution, overview
additional information
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indomethacin-sensitive 3alpha-hydroxysteroid dehydrogenase widely distributed in prostate, spleen, heart, testis, small intestine, stomach, lung and brain
additional information
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low activities found in dog and rabbit liver, no significant activities are detected in extracts of beef, hog, guinea pig, mouse and human liver
additional information
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tissue distribution of AKR1C9, immunohistochemic analysis, overview
additional information
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indomethacin-sensitive 3alpha-hydroxysteroid dehydrogenase widely distributed in prostate, spleen, heart, testis, small intestine, stomach, lung and brain
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