1.1.1.234: flavanone 4-reductase
This is an abbreviated version!
For detailed information about flavanone 4-reductase, go to the full flat file.
Word Map on EC 1.1.1.234
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1.1.1.234
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flavonoid
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dihydroflavonols
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3-deoxyanthocyanidins
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bicolor
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sorghum
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moench
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anthocyanidins
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luteolinidin
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flavone
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purple
- 1.1.1.234
- flavonoid
- dihydroflavonols
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3-deoxyanthocyanidins
- bicolor
- sorghum
- moench
- anthocyanidins
- luteolinidin
- flavone
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purple
Reaction
Synonyms
3-deoxyanthocyanidin synthase, FNR, Sb06g029550, Sb06g029550 protein
ECTree
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General Information
General Information on EC 1.1.1.234 - flavanone 4-reductase
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evolution
the enzyme belongs to the plant DFR superfamily, phylogenetic analysis
malfunction
Sorghums with a tan injury response have non-functional FNR alleles (p). The FNR gene of cultivar M36001 has an insertion in the coding region. Sorghums with a tan injury response have lower levels of flavan-4-ols (precursors of apigeninidin and luteolinidin-apiforol and luteoforol, respectively) than do sorghums with a purple or red injury response and are unable to synthesize 3-deoxyanthocyanidins
metabolism
physiological function
additional information
homology modeling on the basis of the crystal structure of grape dihydroflavonol 4-reductase, PDB ID 3C1T
the DFR gene is a key gene late in the flavonoid biosynthesis pathway, overview. The enzyme posesses flavanone 4-reductase activity and also is a key enzyme in the biosynthesis of anthocyanidins, proanthocyanidins, and other flavonoids
metabolism
the enzyme, encoded by gene Sb06g029550, is involved in the 3-deoxyanthocyanidin synthesis pathway
the enzyme is of importance in plant development
physiological function
the enzyme is responsible for the synthesis of 3-deoxyanthocyanidins. The variation of purple-red-orange is explained by the balance of two 3-deoxyanthocyanidins, uteolinidin and apigeninidin. The balance is controlled by the expression level of flavonoid 3'-hydroxylase (F3'H), which encodes a protein that hydroxylates the 3' position of the B-ring of naringenin to produce a precursor of luteolinidin
physiological function
upon wounding or pathogen invasion, leaves of Sorghum bicolor plants with the P gene turn purple, whereas leaves with the recessive allele turn brown or tan. This purple phenotype is determined by the production of two 3-deoxyanthocyanidins, apigeninidin and luteolinidin, which are not produced by the tan-phenotype plants