1.1.1.236: tropinone reductase II

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For detailed information about tropinone reductase II, go to the full flat file.

Reaction

Synonyms

DnTR2, More, pseudotropine forming tropinone reductase, pseudotropine reductase II, pseudotropine-forming tropinone reductase, pseudotropinone forming tropinone reductase, TR-II, TR2, TRII, tropinone (psi-tropine-forming) reductase, tropinone reductase, tropinone reductase I, tropinone reductase II, tropinone reductase-II

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.236 tropinone reductase II

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Results	in table
1	Activating Compound
24	AA Sequence
1	CAS Registry Number
24	Cloned(Commentary)
34	Cofactor
4	Crystallization (Commentary)
1	Expression
11	General Information
5	General Stability
2	Inhibitors
1	kcat/KM [mM/s]
82	KM Value [mM]
21	Molecular Weight [Da]
54	Natural Substrates/ Products (Substrates)
72	Organism
3	Pathway
11	PDB ID
17	pH Optimum
3	pH Range
3	pH Stability
2	pI Value
2	Protein Variants
21	Purification (Commentary)
1	Reaction
3	Reaction Type
71	Reference
85	Source Tissue
8	Specific Activity [micromol/min/mg]
3	Storage Stability
132	Substrates and Products (Substrate)
24	Subunits
39	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
5	Turnover Number [1/s]

pH Stability

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pH Stability on EC 1.1.1.236 - tropinone reductase II

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pH STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

4 - 8

Datura stramonium

-

keeps 90% of maximal activity in the range pH 5.2-8.2

348027

5.8 - 8.5

Hyoscyamus niger

-

more acidic buffers inactivate the enzyme highly, 8% of the maximum activity at pH 4.5, more alkaline buffers inhibit the activity less strongly, 61% of the maximum activity at pH 8.5

348021, 348025