1.1.1.267: 1-deoxy-D-xylulose-5-phosphate reductoisomerase

This is an abbreviated version!
For detailed information about 1-deoxy-D-xylulose-5-phosphate reductoisomerase, go to the full flat file.

Word Map on EC 1.1.1.267

1.1.1.267

isoprenoids

fosmidomycin

plasmodium

falciparum

antimalarial

terpenoids

isopentenyl

non-mevalonate

mevalonate

isoprene

phosphonate

drug development

dimethylallyl

mevalonate-independent

medicine

biotechnology

Reaction

Synonyms

1-deoxy-D-xylulose 5-phosphate isomeroreductase, 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 1-deoxy-D-xylulose-5-phosphate, 1-deoxy-D-xylulose-5-phosphate reductoisomerase, 1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose 5-phosphate reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase, 2C-methyl-D-erythritol 4-phosphate synthase, 2C-methyl-D-erythritol-4-phosphate synthase, AaDXR, CaDXR, deoxyxylulose 5-phosphate reductoisomerase, deoxyxylulosephosphate reductoisomerase, DOXP reductoisomerase, DOXP-reductoisomerase, DXP reductoisomerase, DXP-reductoisomerase, DXR, DXR1, DzDXR, EcDXR, FtIspC, IspC, MEP synthase, meps, methylerythritol phosphate synthase, MtbIspC, MtDXR, Os01g01710, OsDXR, PdDXR, PfDXR, PtDXR, Rv2870c, SaDXR, VvDxr, YpIspC

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.267 1-deoxy-D-xylulose-5-phosphate reductoisomerase

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Results	in table
7	Activating Compound
35608	AA Sequence
29	Application
1	CAS Registry Number
58	Cloned(Commentary)
106	Cofactor
16	Crystallization (Commentary)
10	Expression
64	General Information
162	IC50 Value
385	Inhibitors
14	kcat/KM [mM/s]
64	Ki Value [mM]
85	KM Value [mM]
21	Localization
76	Metals/Ions
24	Molecular Weight [Da]
66	Natural Substrates/ Products (Substrates)
540	Organism
7	Pathway
136	PDB ID
30	pH Optimum
1	pH Range
1	pH Stability
6	pI Value
4	Posttranslational Modification
47	Protein Variants
28	Purification (Commentary)
14	Reaction
3	Reaction Type
134	Reference
92	Source Tissue
8	Specific Activity [micromol/min/mg]
8	Storage Stability
141	Substrates and Products (Substrate)
29	Subunits
190	Synonyms
1	Systematic Name
29	Temperature Optimum [°C]
2	Temperature Range [°C]
4	Temperature Stability [°C]
36	Turnover Number [1/s]

KM Value

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KM Value on EC 1.1.1.267 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase

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0.69

(3R,4S)-dihydroxy-5-oxohexylphosphonic acid

Synechocystis sp.

654973

1.3

1,2-dideoxy-D-threo-3-hexulose 6-phosphate

Synechocystis sp.

pH 7.8, 37°C, recombinant mutant W204F

671590

0.0031 - 12

1-deoxy-D-xylulose 5-phosphate

26 entries

0.004 - 0.24

1-deoxy-D-xylulose-5-phosphate

12 entries

1-deoxy-L-erythrulose

Mycobacterium tuberculosis

pH 7.5, 25°C, recombinant enzyme in absence or presence of phosphite dianion

724374

0.227

1-fluoro-1-deoxy-D-xylulose 5-phosphate

Escherichia coli

pH 7.6, 37°C, recombinant enzyme

672040, 675577

0.1

1-fluoro-1-deoxy-D-xylulose-5-phosphate

Escherichia coli

656890

0.084 - 0.972

2-C-methyl-D-erythritol 4-phosphate

3 entries

0.00537

3-[2H]-D-1-deoxyxylulose-5-phosphate

Escherichia coli

684434

0.00423

4-[2H]-D-1-deoxyxylulose-5-phosphate

Escherichia coli

684434

0.042 - 0.294

methyl-D-erythritol-4-phosphate

3 entries

0.05 - 0.41

NADH

3 entries

0.17 - 1

NADP+

4 entries

0.0004 - 0.0825

NADPH

20 entries

additional information

3 entries