1.1.1.270: 3beta-hydroxysteroid 3-dehydrogenase

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For detailed information about 3beta-hydroxysteroid 3-dehydrogenase, go to the full flat file.

Reaction

Synonyms

17beta-HSD7, 17beta-hydroxysteroid dehydrogenase type 7, 3-keto reducing enzyme, 3-keto reductase, 3-keto-reductase, 3-ketoreductase, 3-ketosteroid reductase, 3-KSR, 3-oxo steroid reductase, 3-oxosteroid reductase, 3beta-HSD, 3beta-HSD1, 3beta-HSD2, 3beta-HSDH, 3beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase type 1, 3beta-hydroxysteroid dehydrogenase/Delta 5->4-isomerase type 1, 3beta-hydroxysteroid dehydrogenase/Delta 5->4-isomerase type 2, 3beta-hydroxysteroid dehydrogenase/isomerase, AKR1C1, AKR1C2, AKR1Cs, aldo-keto reductase 1C2, CDD59473, Erg27, Erg27p, Hsd17, HSD17B7, HSD3B1, reductase, 3-oxo steroid, reductive 3beta-HSD, SDR11E1, SDR11E2, steroid-3-ketoreductase, sterol 3-ketoreductase, sterone-reducing enzyme, type 3 3alpha-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.270 3beta-hydroxysteroid 3-dehydrogenase

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Results	in table
4	Activating Compound
363	AA Sequence
3	Application
1	CAS Registry Number
11	Cloned(Commentary)
27	Cofactor
878	Disease/ Diagnostics
1	Expression
22	General Information
4	General Stability
15	IC50 Value
37	Inhibitors
8	kcat/KM [mM/s]
10	Ki Value [mM]
43	KM Value [mM]
19	Localization
1	Metals/Ions
3	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
32	Organism
14	Pathway
8	pH Optimum
19	Protein Variants
5	Purification (Commentary)
4	Reaction
3	Reaction Type
30	Reference
46	Source Tissue
5	Specific Activity [micromol/min/mg]
140	Substrates and Products (Substrate)
1	Subunits
52	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
2	Temperature Stability [°C]
32	Turnover Number [1/s]

Application

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Application on EC 1.1.1.270 - 3beta-hydroxysteroid 3-dehydrogenase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

analysis

Rattus norvegicus

-

enzyme can be used for reconstitution of 4-methyl sterol demethylations of cholesterol biosynthesis from lanosterol

286472

medicine

Homo sapiens

-

the selective inhibition of human 3beta-HSD1 in breast tumors represents a potential treatment for hormone-sensitive breast cancer

725813

synthesis

Saccharomyces cerevisiae

Q12452

used of mutated 3-ketosteroid reductase (Erg27) to obtain radioactive and non-radioactive intermediates of sterol biosynthesis hardly or not available commercially. The strategies are either incubation of cell homogenates of an Erg27-deletant strain with radioactive lanosterol, or incubation of growing cells of a strain expressing point-mutated 3-ketosteroid reductase with radioactive acetate. Chemical reduction of both radioactive and non-radioactive 3-keto sterones gives the physiological 3-beta-OH sterols, as well as the non-physiological 3-alpha-OH isomers

740936