1.1.1.270: 3beta-hydroxysteroid 3-dehydrogenase
This is an abbreviated version!
For detailed information about 3beta-hydroxysteroid 3-dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.270
-
1.1.1.270
-
steroidogenic
-
testosterone
-
androgen
-
progesterone
-
steroidogenesis
-
adrenal
-
leydig
-
star
-
cyp11a1
-
testicular
-
p450scc
-
aromatase
-
lutein
-
lh
-
pregnenolone
-
androstenedione
-
dehydroepiandrosterone
-
akr1c1
-
granulosa
-
trilostane
-
17alpha-hydroxylase
-
3betahsd
-
hsd3b2
-
dheas
-
dihydrotestosterone
-
lhcgr
-
srd5a1
-
p450arom
-
5alpha-reductase
-
21-hydroxylase
-
3-ketosteroids
-
scarb1
-
hsd11b1
-
22r-hydroxycholesterol
-
5alpha-dihydrotestosterone
-
neurosteroids
-
20alpha-hydroxysteroid
-
11beta-hydroxylase
-
cyp21
-
3alpha-hsds
-
insl3
-
intratesticular
-
lh-stimulated
-
adrenarche
-
17-hydroxypregnenolone
-
medicine
-
17alpha-hydroxyprogesterone
-
delta5
-
pre-receptor
-
synthesis
-
analysis
-
20alpha-hsd
-
17alpha-hydroxylase/17,20-lyase
- 1.1.1.270
-
steroidogenic
- testosterone
- androgen
- progesterone
-
steroidogenesis
- adrenal
- leydig
- star
- cyp11a1
- testicular
- p450scc
- aromatase
- lutein
- lh
- pregnenolone
- androstenedione
- dehydroepiandrosterone
- akr1c1
-
granulosa
- trilostane
- 17alpha-hydroxylase
- 3betahsd
- hsd3b2
- dheas
- dihydrotestosterone
-
lhcgr
- srd5a1
- p450arom
-
5alpha-reductase
- 21-hydroxylase
- 3-ketosteroids
-
scarb1
- hsd11b1
-
22r-hydroxycholesterol
- 5alpha-dihydrotestosterone
-
neurosteroids
-
20alpha-hydroxysteroid
-
11beta-hydroxylase
- cyp21
- 3alpha-hsds
- insl3
-
intratesticular
-
lh-stimulated
-
adrenarche
- 17-hydroxypregnenolone
- medicine
- 17alpha-hydroxyprogesterone
-
delta5
-
pre-receptor
- synthesis
- analysis
- 20alpha-hsd
- 17alpha-hydroxylase/17,20-lyase
Reaction
Synonyms
17beta-HSD7, 17beta-hydroxysteroid dehydrogenase type 7, 3-keto reducing enzyme, 3-keto reductase, 3-keto-reductase, 3-ketoreductase, 3-ketosteroid reductase, 3-KSR, 3-oxo steroid reductase, 3-oxosteroid reductase, 3beta-HSD, 3beta-HSD1, 3beta-HSD2, 3beta-HSDH, 3beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase type 1, 3beta-hydroxysteroid dehydrogenase/Delta 5->4-isomerase type 1, 3beta-hydroxysteroid dehydrogenase/Delta 5->4-isomerase type 2, 3beta-hydroxysteroid dehydrogenase/isomerase, AKR1C1, AKR1C2, AKR1Cs, aldo-keto reductase 1C2, CDD59473, Erg27, Erg27p, Hsd17, HSD17B7, HSD3B1, reductase, 3-oxo steroid, reductive 3beta-HSD, SDR11E1, SDR11E2, steroid-3-ketoreductase, sterol 3-ketoreductase, sterone-reducing enzyme, type 3 3alpha-hydroxysteroid dehydrogenase
ECTree
1.1.1.270 3beta-hydroxysteroid 3-dehydrogenaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.1.1.270 - 3beta-hydroxysteroid 3-dehydrogenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
17alpha-hydroxypregnenolone + NADH + H+
17alpha-hydroxyprogesterone + NAD+
-
-
-
-
?
2 17beta-hydroxy-5alpha-androstan-3-one + 2 NADPH + 2 H+
5alpha-androstane-3beta,17beta-diol + 5alpha-androstane-3alpha,17beta-diol + 2 NADP+
24-ethylidenelophenone + NADPH
24-ethylidenelophenol + NADP+
-
oxidation: poor
-
r
24-methylenecycloartanone + NADPH
24-methylenecycloartanol + NADP+
-
7% compared with cholest-7-en-3-one, DELTA7-cholestenone
-
ir
24-methylenelophenone + NADPH
24-methylenelophenol + NADP+
-
35% compared with cholest-7-en-3-one, DELTA7-cholestenone
-
?
24-methylenepollinastanone + NADPH + acetate
24-methylenepollinastanol + NADP+
-
70% compared with cholest-7-en-3-one, DELTA7-cholestenone
-
?
24RS-dihydrocycloeucalenone + NADPH
24RS-dihydrocycloeucalenol + NADP+
-
53% compared with cholest-7-en-3-one, DELTA7-cholestenone
-
?
3-keto-5alpha-androstane steroids + NADPH
3beta-hydroxy-5alpha-androstane steroids + NADP+
-
-
-
ir
3-oxocholic acid + NAD(P)H + H+
cholic acid + NAD(P)+
10.3% of the activity compared to the substrate isodeoxycholic acid
-
-
r
3-oxodeoxycholic acid + NAD(P)H + H+
isodeoxycholic acid + NAD(P)+
55.2% of the activity compared to the substrate isodeoxycholic acid
-
-
r
3alpha-androstanediol + NAD+
? + NADH
AKR1C2 and AKR1C4 act as 3alpha-hydroxysteroid oxidase, AKR1C3 predominantly acts as 17beta-hydroxysteroid oxidase catalyzing the conversion of 3alpha-diol to androsterone, negligible activity with the 3beta-androstanediol
-
-
?
4,4-gem-dimethyl-5alpha-cholest-7-en-3-one + NADPH
4,4-gem-dimethyl-5alpha-cholest-7-en-3beta-ol + NADP+
4alpha-methyl-5alpha-cholest-7-en-3-one + NADPH
4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP+
-
best substrate, reduction consistently about two times greater for monosubstituted steroid
-
?
4alpha-methylfecosterone + NADPH + H+
4alpha-methylfecosterol + NADP+
-
-
4alpha-methylfecosterol is further converted to ergosterol
-
?
4alpha-methylzymosterol + NADP+
3-dehydro-4-methylzymosterol + NADPH + H+
-
-
-
-
?
4beta-methyl-28-nor-24RS-dihydrocycloeucalenone + NADPH
4beta-methyl-28-nor-24RS-dihydrocycloeucalenol + NADP+
-
27% compared with cholest-7-en-3-one, DELTA7-cholestenone
-
?
5alpha-androstan-3,17-dione + NADPH + H+
5alpha-androstan-3beta-ol-17-one + NADP+
-
-
-
-
r
5alpha-dihydrotestosterone + NADPH + H+
3beta,17beta-dihydroxy-5alpha-androstane + NADP+
-
-
-
-
r
5alpha-dihydrotestosterone + NADPH + H+
5alpha-androstan-3beta,17beta-diol + NADP+
i.e. DHT, reductive 3beta-HSD activity of AKR1C1 yielding the 3beta,17-diol, preferred reaction
-
-
?
5alpha-pregnan-3,20-dione + NADPH + H+
5alpha-pregnane-3beta-ol-20-one + NADP+
-
-
-
-
r
5alpha-pregnane-21-ol-3,20-dione + NADPH + H+
5alpha-pregnane-3beta,21-diol-20-one + NADP+
-
-
-
-
r
5beta-androstan-3,17-dione + NADPH + H+
5beta-androstan-3beta-ol-17-one + NADP+
-
-
-
-
r
5beta-androstan-3beta-ol-17-one + NADP+
5beta-androstan-3,17-dione + NADPH + H+
-
-
-
-
r
5beta-androstane-3beta,17beta-diol + NADP+
5beta-androstane-17beta-ol-3-one + NADPH + H+
-
-
-
-
r
5beta-cholanic acid-3,7-dione + NADPH + H+
5beta-cholanic acid-3beta-ol-7-one + NADP+
-
-
-
-
r
5beta-dihydrocorticosterone + NADPH + H+
(3beta,5beta,11beta)-3,11,21-trihydroxypregnan-20-one + NADP+
-
-
-
-
r
5beta-dihydrotestosterone + NADPH + H+
3beta,17beta-dihydroxy-5beta-androstane + NADP+
-
-
-
-
r
5beta-hydroxy-5beta cholanic acid + NADP+
3-oxo-5-beta-cholanic acid + NADPH + H+
-
-
-
-
r
5beta-pregnan-3,20-dione + NADPH + H+
5beta-pregnane-3beta-ol-20-one + NADP+
-
-
-
-
r
5beta-pregnane-20-ol-3-one + NADPH + H+
5beta-pregnane-3beta,20-diol + NADP+
-
-
-
-
r
5beta-pregnane-21-ol-3,20-dione + NADPH + H+
5beta-pregnane-3beta,21-diol-20-one + NADP+
-
-
-
-
r
5beta-pregnane-3beta,20alpha-diol + NADP+
5beta-pregnane-20alpha-ol-3-one + NADPH + H+
-
-
-
-
r
5beta-pregnane-3beta,20beta-diol + NADP+
5beta-pregnane-20beta-ol-3-one + NADPH + H+
-
-
-
-
r
5beta-pregnane-3beta,21-diol-20-one + NADP+
5beta-pregnane-21-ol-3,20-dione + NADPH + H+
-
-
-
-
r
5beta-pregnane-3beta-ol-20-one + NADP+
5beta-pregnan-3,20-dione + NADPH + H+
-
-
-
-
r
avenastenone + NADPH
avenasterol + NADP+
-
more than 72% compared with cholest-7-en-3-one, DELTA7-cholestenone
-
?
chenodeoxycholic acid + NAD(P)+
3-oxo-chenodeoxycholic acid + NAD(P)H + H+
11.7% of the activity compared to the substrate isodeoxycholic acid
-
-
r
cholest-7-en-3-one + NADPH
3beta-hydroxy-cholest-7-ene + NADP+
-
DELTA7-cholestenone, best substrate
DELTA7-cholesterol
ir
cholestanone + NADPH
cholestanol + NADP+
-
57% compared with cholest-7-en-3-one, DELTA7-cholestenone
-
?
cholic acid + NAD(P)+
3-oxo-cholic acid + NAD(P)H + H+
12.7% of the activity compared to the substrate isodeoxycholic acid
-
-
r
cycloartenone + NADPH
cycloartenol + NADP+
-
7% compared with cholest-7-en-3-one, DELTA7-cholestenone
-
ir
cyclolaudenone + NADPH
cyclolaudenol + NADP+
-
10% compared with cholest-7-en-3-one, DELTA7-cholestenone
-
?
deoxycholic acid + NAD(P)+
3-oxo-deoxycholic acid + NAD(P)H + H+
22.4% of the activity compared to the substrate isodeoxycholic acid
-
-
r
glycochenodeoxycholic acid + NAD(P)+
? + NAD(P)H + H+
13.2% of the activity compared to the substrate isodeoxycholic acid
-
-
r
glycocholic acid + NAD(P)+
? + NAD(P)H + H+
12.4% of the activity compared to the substrate isodeoxycholic acid
-
-
r
glycodeoxycholic acid + NAD(P)+
? + NAD(P)H + H+
20.6% of the activity compared to the substrate isodeoxycholic acid
-
-
r
isodeoxycholic acid + NADP+
3-oxodeoxycholic acid + NADPH + H+
-
-
-
r
progesterone + NADPH
pregn-4-ene-20alpha-ol-3-one + NADP+
i.e. pregn-4-ene-3,20-dione
-
-
?
pyridine-3-aldehyde + NADP+
pyridin-3-ylmethanol + NADPH + H+
-
-
-
-
?
spinastenone + NADPH
spinasterol + NADP+
-
32% compared with cholest-7-en-3-one, DELTA7-cholestenone
-
?
taurochenodeoxycholic acid + NAD(P)+
? + NAD(P)H + H+
11.5% of the activity compared to the substrate isodeoxycholic acid
-
-
r
taurocholic acid + NAD(P)+
? + NAD(P)H + H+
11.5% of the activity compared to the substrate isodeoxycholic acid
-
-
r
taurodeoxychloic acid + NAD(P)+
? + NAD(P)H + H+
21.8% of the activity compared to the substrate isodeoxycholic acid
-
-
r
[7alpha,17alpha]-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one + NADPH
[7alpha,17alpha]-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-ol + NADP+
(4-methyl)zymosterone + NADPH + H+
(4-methyl)zymosterol + NADP+
cholesterol pathway
-
-
?
17beta-hydroxy-5alpha-androstan-3-one + NADPH
5alpha-androstane-3beta,17beta-diol + NADP+
-
5alpha-dihydrotestosterone
androstanediol, 5alpha-androstane-3alpha,17beta-diol or 5alpha-androstane-3beta,17beta-diol
?
17beta-hydroxy-5alpha-androstan-3-one + NADPH
5alpha-androstane-3beta,17beta-diol + NADP+
-
DHT
androstanediol, 5alpha-androstane-3alpha,17beta-diol or 5alpha-androstane-3beta,17beta-diol
?
17beta-hydroxy-5alpha-androstan-3-one + NADPH
5alpha-androstane-3beta,17beta-diol + NADP+
-
dihydrotestosterone
androstanediol, 5alpha-androstane-3alpha,17beta-diol or 5alpha-androstane-3beta,17beta-diol
?
17beta-hydroxy-5alpha-androstan-3-one + NADPH
5alpha-androstane-3beta,17beta-diol + NADP+
-
5alpha-dihydrotestosterone
androstanediol, corresponding 3beta-hydroxysteroid
ir
17beta-hydroxy-5alpha-androstan-3-one + NADPH
5alpha-androstane-3beta,17beta-diol + NADP+
-
DHT
androstanediol, corresponding 3beta-hydroxysteroid
ir
17beta-hydroxy-5alpha-androstan-3-one + NADPH
5alpha-androstane-3beta,17beta-diol + NADP+
-
dihydrotestosterone
androstanediol, corresponding 3beta-hydroxysteroid
ir
2 17beta-hydroxy-5alpha-androstan-3-one + 2 NADPH + 2 H+
5alpha-androstane-3beta,17beta-diol + 5alpha-androstane-3alpha,17beta-diol + 2 NADP+
-
the rates of 3alpha-diol versus 3beta-diol formation varies significantly among the isoforms. AKR1C1 predominantly catalyzes the formation of 3beta-diol, whereas AKR1C2 and AKR1C4 predominantly catalyze the formation of 3alpha-diol. AKR1C3 shows relatively low reductive activity towards 17beta-hydroxy-5alpha-androstan-3-one, in which 3alpha-diol and 3beta-diol is formed in almost equal amounts
-
?
2 17beta-hydroxy-5alpha-androstan-3-one + 2 NADPH + 2 H+
5alpha-androstane-3beta,17beta-diol + 5alpha-androstane-3alpha,17beta-diol + 2 NADP+
AKR1cs are a source of beta-tetrahydrosteroids. This is of physiological significance because the formation of 3beta-diol in contrast to 3alpha-diol is virtually irreversible, the 3beta-diol is a pro-apoptotic ligand for estrogen receptor beta, and 3beta-tetrahydrosteroids act as gamma-aminobutyric acid type A receptor antagonists
-
-
?
4,4-gem-dimethyl-5alpha-cholest-7-en-3-one + NADPH
4,4-gem-dimethyl-5alpha-cholest-7-en-3beta-ol + NADP+
-
-
-
?
4,4-gem-dimethyl-5alpha-cholest-7-en-3-one + NADPH
4,4-gem-dimethyl-5alpha-cholest-7-en-3beta-ol + NADP+
-
-
-
?
5alpha-androstane-3,17-dione + NADPH
epi-androsterone + NADP+
-
3-ketosteroid reductase activity of the human 3(alpha-beta)-hydroxysteroid epimerase, stereoselective reduction
epi-ADT
?
5alpha-androstane-3,17-dione + NADPH
epi-androsterone + NADP+
-
5alpha-dione
epi-ADT
?
5alpha-androstane-3,17-dione + NADPH
epi-androsterone + NADP+
-
A-dione
-
-
ir
5alpha-dihydrotestosterone + NADPH + H+
5alpha-androstan-3alpha,17beta-diol + NADP+
-
-
-
-
?
5alpha-dihydrotestosterone + NADPH + H+
5alpha-androstan-3alpha,17beta-diol + NADP+
-
in prostate cells AKR1C2 acts as a 3-ketosteroid reductase to eliminate 5alpha-dihydrotestosterone and prevents activation of androgen receptor. AKR1C2 does not act as an oxidase due to either potent product inhibition by NADPH or because it cannot surmount the oxidative 17beta-hydroxysteroid dehydrogenase present. AKR1C2 is not a source of 5alpha-dihydrotestosterone in PC-3 cells
-
-
?
5alpha-dihydrotestosterone + NADPH + H+
5alpha-androstan-3alpha,17beta-diol + NADP+
i.e. DHT, reductive 3alpha-HSD activity of AKR1C1 yielding the 3alpha,17-diol, low activity
-
-
?
cycloeucalenone + NADPH + H+
cycloeucalenol + NADP+
-
putative endogenous substrate for sterone reductase
reverse oxidation: about 35% of forward reductase rate, 17-(4-isopropyl-1-methyl-pent-4-enyl)-4,13,14-trimethyl-tetradecahydro-cyclopropa[9,10]cyclopenta[a]phenanthren-3beta-ol
r
cycloeucalenone + NADPH + H+
cycloeucalenol + NADP+
-
68% compared with cholest-7-en-3-one, DELTA7-cholestenone
reverse oxidation: about 35% of forward reductase rate, 17-(4-isopropyl-1-methyl-pent-4-enyl)-4,13,14-trimethyl-tetradecahydro-cyclopropa[9,10]cyclopenta[a]phenanthren-3beta-ol
r
DELTA7-chondrillastenone + NADPH
DELTA7-chondrillasterol + NADP+
-
70% compared with cholest-7-en-3-one, DELTA7-cholestenone
17-(4-ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3beta-ol
?
DELTA7-chondrillastenone + NADPH
DELTA7-chondrillasterol + NADP+
-
5alpha,28beta(H)-stigmasta-7,22-dien-3-one
17-(4-ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3beta-ol
?
dihydrotestosterone + NADPH + H+
5alpha-androstane-3beta,17beta-diol + NADP+
-
-
-
?
dihydrotestosterone + NADPH + H+
5alpha-androstane-3beta,17beta-diol + NADP+
steroid hormone pathway
-
-
?
obtusifolione + NADPH
obtusifoliol + NADP+
-
4,14-dimethyl-ergosta-8,24(28)-dien-3-one
4,14-dimethyl-ergosta-8,24(28)-dien-3-ol
?
obtusifolione + NADPH
obtusifoliol + NADP+
-
43% compared with cholest-7-en-3-one, DELTA7-cholestenone
4,14-dimethyl-ergosta-8,24(28)-dien-3-ol
?
obtusifolione + NADPH
obtusifoliol + NADP+
-
4,14-dimethyl-ergosta-8,24(28)-dien-3-one
4,14-dimethyl-ergosta-8,24(28)-dien-3-ol
?
progesterone + NADPH + H+
4-pregnen-3beta-ol-20-one + NADP+
steroid hormone pathway
-
-
?
[7alpha,17alpha]-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one + NADPH
[7alpha,17alpha]-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-ol + NADP+
i.e. tibolone, a synthetic hormone
-
-
?
[7alpha,17alpha]-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one + NADPH
[7alpha,17alpha]-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-ol + NADP+
-
i.e. tibolone, a synthetic hormone
reaction product determination and analysis
-
?
additional information
?
-
-
substrate for 3-ketoreductase in the first sterol C-4 demethylation cycle is 4alpha-methylfecosterone, whereas that for the second C-4 demethylation cycle is fecosterone
-
-
?
additional information
?
-
-
NADPH-dependent 3-ketosteroid reductase catalyzes reduction of the 3-keto group to a 3beta-hydroxyl group
-
-
?
additional information
?
-
-
enzyme of sterol, ergosterol, biosynthesis, enzyme catalyzes last step in demethylation at C-4
-
-
?
additional information
?
-
-
3-ketosteroid reductase activity of the human 3(alpha-beta)-hydroxysteroid epimerase catalyzes reduction of 3-ketosteroids to form 3beta-hydroxysteroids
-
-
?
additional information
?
-
-
HSD17B7 participates in postsqualene cholesterol biosynthesis, HSD17B7 is a novel candidate for inborn errors of cholesterol metabolism
-
-
?
additional information
?
-
-
tibolone is used to treat climacteric symptoms and prevent osteoporosis, it exerts tissue-selective effects via site-specific metabolism into 3alpha- and 3beta-hydroxymetabolites and a DELTA4-isomer, In Hep-G2 cell cytosol and intact cells tibolone is exclusively reduced to 3beta-hydroxytibolone, tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily, overview
-
-
?
additional information
?
-
AKR1C1 is a cytosolic hydroxysteroid dehydrogenase, that reduces 3-ketosteroids and 20-ketosteroids, overview, molecular docking simulations with generation of docking targets, overview
-
-
?
additional information
?
-
-
AKR1C1 is a cytosolic hydroxysteroid dehydrogenase, that reduces 3-ketosteroids and 20-ketosteroids, overview, molecular docking simulations with generation of docking targets, overview
-
-
?
additional information
?
-
-
comparison of substrate specificity and enantioselectivity of AKR1C isozymes, overview
-
-
?
additional information
?
-
-
both isoforms of the enzyme catalyze the conversion of 3beta-hydroxy-5-ene-steroids (dehydroepiandrosterone, 17alpha-hydroxypregnenolone, pregnenolone) to 3-oxo-4-ene-steroids (androstenedione, 17alpha-hydroxyprogestrone, progesterone) on a single, dimeric protein containing both enzyme activities
-
-
?
additional information
?
-
-
enzyme might form complexes with other proteins, including possibly DNA-binding proteins, under low ionic strength conditions
-
-
?
additional information
?
-
-
HSD17B7 participates in postsqualene cholesterol biosynthesis
-
-
?
additional information
?
-
-
the enzyme, termed AKR1B19, acts not only as a reductase for reactive carbonyl compounds derived from lipid peroxidation like AR-like proteins of other species, but also as a superior reductive 3beta-HSD for 3-keto-5alpha/beta-dihydro-C19/C21/C24-steroids
-
-
?
additional information
?
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substrate specificity of the bifunctional enzyme, for carbonyl compounds and steroids, overview. No reductase activity is observed for 17- and 20-ketosteroids, DELTA4-3-ketosteroids (testosterone, 4-androstene-3,17-dione and progesterone), and prostaglandins (D2, E2, and A1). In the reverse reaction, the enzyme oxidizes 3beta-hydroxy-5alpha/beta-dihydrosteroids, but shows no significant dehydrogenase activity for DELTA5-3beta-hydroxysteroids (dehydroepiandrosterone, pregnenolone, and 5-pregnene-3beta,20alpha-diol) and 3alpha-hydroxysteroids (5alpha/beta-androstan-3alpha-ol-17-ones, 5alpha/beta-androstane-3alpha,17beta-diols, 5alpha/beta-pregnan-3alpha-ol-20-ones and lithocholic acid). The reactivity towards all-trans-retinal of AKR1B19 is low
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catalyzes the conversion of 3-keto-saturated steroids such as 5alpha-dihydrotestosterone, DHT, and 5alpha-androstane-3,17-dione, A-dione, into less active steroids
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sterol substrate specificity with 4alpha-monomethyl- and 4,4-dimethyl-3-ketosteroids
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catalyzes NADPH-dependent reduction of 3-ketosteroid intermediates, 4-methyl sterol intermediates, of cholesterol biosynthesis from lanosterol, regenerates 3beta-hydroxy sterol
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enzyme of mevalonate pathway for biosynthesis of cholesterol from lanosterol
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involved in the 10-step oxidative removal of the 4-gem-dimethyl group of sterols
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step of biosynthesis of hormonal steroids
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the enzyme is also involved in synthesis of estradiol and estrone, neurosteroids paly a role in brain develkopment and in stimulation and control of song function
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3-keto reducing enzyme is specific for a 5alpha, trans A/B ring junction in the sterone substrate, as found in all sterol biosynthesis intermediates
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4alpha-methyl-9beta,19-cyclo-C30-sterones and 4-desmethyl-DELTA7-C27-sterones or C30-sterones are preferentially reduced, 4,4-dimethyl-C30-sterones or C31-sterones react poorly. Produces stereoselectively corresponding 3beta-alcohol derivatives, no 3alpha-alcohol product is formed
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catalyzes NADPH-dependent C-3 reduction of various sterones to produce stereoselectively the corresponding 3beta-hydroxy derivatives
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constitutive component of microsomal sterol 4-demethylation complex in photosynthetic organism
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