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1.1.1.284: S-(hydroxymethyl)glutathione dehydrogenase

This is an abbreviated version!
For detailed information about S-(hydroxymethyl)glutathione dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.284

Reaction

S-(hydroxymethyl)glutathione
+
NAD(P)+
=
S-formylglutathione
+
NAD(P)H
+
H+

Synonyms

ADH III, ADH3, ADH4, ADH5, AdhC, alcohol dehydrogenase 3, alcohol dehydrogenase 5, alcohol dehydrogenase class III, alcohol dehydrogenase class-3, Alcohol dehydrogenase SFA, AN7632.2, AtGSNOR, c-ADH, carbonyl reductase 1, CBR1, class III ADH, class III alcohol dehydrogenase, dehydrogenase, formaldehyde, EC 1.2.1.1, FALDH, FDH, FLD, FldA, formaldehyde dehydrogenase, formaldehyde dehydrogenase (glutathione), formic dehydrogenase, FrxA, GD-FAlDH, GFD, glutathione (GSH)-dependent formaldehyde dehydrogenase, glutathione-dependent alcohol dehydrogenase, Glutathione-dependent formaldehyde dehydrogenase, GS-FDH, GSH-FDH, GSNO reductase, GSNO-R, GSNOR, GSNOR1, HMGSH dehydrogenase, HOT5, MGG_06011, NAD- and glutathione-dependent formaldehyde dehydrogenase, NAD-dependent formaldehyde dehydrogenase, NAD-linked formaldehyde dehydrogenase, NADH-GSNO oxidoreductase, nitroreductase, NTRA, Os02g0815500, Os02G57040, OsGSNOR, PmFLD1, PmGSNOR, S-nitrosoglutathione reductase, SA0UHSC_00833, SFA1, SlGSNOR, SoGSNOR, Tc-GFD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.284 S-(hydroxymethyl)glutathione dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.284 - S-(hydroxymethyl)glutathione dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
1 mM, 30% inhibition
12-oxododecanoic acid
2,2'-dipyridyl
-
1 mM, 20% inhibition
2-mercaptoethanol
inhibits both the reductase and dehydrogenase reactions by 30% at 1 mM
3-(1-tert-butyl-4-amino-1H-indazol-3-yl)phenol
-
CBR1 inhibitor, does not inhibit NADH-dependent S-nitrosoglutathione reduction
3-(5-(4-(1H-imidazol-1-yl) phenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl) propionic acid
-
3-[1-(4-acetylphenyl)-5-phenyl-1H-pyrrol-2-yl]propanoic acid
4-([2-[(2-cyanobenzyl)sulfanyl]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl)benzoic acid
4-Methylpyrazole
-
low sensitivity towards the potent inhibitor of alcohol dehydrogenase 1 enzymes
5-chloro-3-(2-[4-ethoxyphenyl) (ethyl) amino]-2-oxoethyl)-1H-indole-2-carboxylic acid
C2
-
5-chloro-3-[2-[(4-ethoxyphenyl)(ethyl)amino]-2-oxoethyl]-1H-indole-2-carboxylic acid
ADP-ribose
AgNO3
-
NADH protects more effectively than NAD+
Alpha-NAD+
ascorbic acid
inhibits both the reductase and dehydrogenase reactions by 30% at 1 mM
citrate
-
1 mM, 24% inhibition
decanedioic acid
-
sebacic acid
Decanoic acid
dithiothreitol
inhibits both the reductase and dehydrogenase reactions by 30% at 1 mM
dodecanedioic acid
-
most efficient inhibitor
dodecanoic acid
folic acid
-
-
formaldehyde
glutathione
GSSG
-
-
imidazole
-
1 mM, 32% inhibition
iodoacetamide
-
1 mM, 20% inhibition
iodoacetate
methyl methanethiosulfonate
-
complete inactivation
methylglyoxal
-
-
N6022
NADPH
-
inhibits reaction with formaldehyde, glutathione and NAD+
NEM
-
1 mM, 35% inhibition
nitroprusside
-
GSNO reductase activity is about two- to threefold decreased following a 2h stress treatment with 1 mM sodium nitroprusside
NO2-
-
1 mM, 14% inhibition
Nonanoic acid
-
pelargonic acid
octanoic acid
p-hydroxymercuribenzoate
-
-
peroxynitrite
treatment of AtGSNOR with peroxynitrite, known as tyrosine nitrating agent, modifies this enzyme and inhibits its activity
pyrazole
S-acetamidoglutathione
-
-
S-formylglutathione
S-hydroxymethylglutathione
-
-
S-Methylglutathione
Tridecanoic acid
-
tridecylic acid
Undecanoic acid
-
undecylic acid, most efficient inhibitor
additional information
-