1.1.1.290: 4-phosphoerythronate dehydrogenase

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For detailed information about 4-phosphoerythronate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.290

1.1.1.290

2-hydroxyacid

pyridoxine

salvage

dehydrogenases

aeruginosa

homodimeric

pyridoxal

5'-phosphate

Reaction

(3R)-3-hydroxy-2-oxo-4-phosphooxybutanoate

Synonyms

4-O-phosphoerythronate dehydrogenase, D-erythronate-4-phosphate dehydrogenase, erythronate-4-phosphate dehydrogenase, More, pdx gene product, PDXB, PdxB 4PE dehydrogenase, RdxB

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.290 4-phosphoerythronate dehydrogenase

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Results	in table
7336	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
7	Cofactor
2	Crystallization (Commentary)
4	General Information
2	IC50 Value
3	Inhibitors
5	kcat/KM [mM/s]
2	Ki Value [mM]
5	KM Value [mM]
1	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
10	Organism
5	Pathway
11	PDB ID
1	pH Optimum
3	Purification (Commentary)
2	Reaction
3	Reaction Type
10	Reference
21	Substrates and Products (Substrate)
2	Subunits
17	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
5	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.1.1.290 - 4-phosphoerythronate dehydrogenase

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D-2-hydroxyglutarate

Escherichia coli

competitive versus 4-phospho-D-erythronate, noncompetitive versus 2-oxoglutarate

724295

D-2-hydroxyglutaric acid

Escherichia coli

competitive inhibitor vs. 4-phospho-D-erythronate and a noncompetitive inhibitor vs. alpha-oxoglutarate

724295

L-2-hydroxyglutaric acid

Escherichia coli

724295