1.1.1.290: 4-phosphoerythronate dehydrogenase
This is an abbreviated version!
For detailed information about 4-phosphoerythronate dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.290
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1.1.1.290
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2-hydroxyacid
-
pyridoxine
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salvage
-
dehydrogenases
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aeruginosa
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homodimeric
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pyridoxal
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5'-phosphate
- 1.1.1.290
-
2-hydroxyacid
- pyridoxine
-
salvage
- dehydrogenases
- aeruginosa
-
homodimeric
- pyridoxal
- 5'-phosphate
Reaction
Synonyms
4-O-phosphoerythronate dehydrogenase, D-erythronate-4-phosphate dehydrogenase, erythronate-4-phosphate dehydrogenase, More, pdx gene product, PDXB, PdxB 4PE dehydrogenase, RdxB
ECTree
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Systematic Name
Systematic Name on EC 1.1.1.290 - 4-phosphoerythronate dehydrogenase
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4-phospho-D-erythronate:NAD+ 2-oxidoreductase
This enzyme catalyses a step in a bacterial pathway for the biosynthesis of pyridoxal 5'-phosphate. The enzyme contains a tightly-bound NAD(H) cofactor that is not re-oxidized by free NAD+. In order to re-oxidize the cofactor and restore enzyme activity, the enzyme catalyses the reduction of a 2-oxo acid (such as 2-oxoglutarate, oxaloacetate, or pyruvate) to the respective (R)-hydroxy acid [6]. cf. EC 1.1.1.399, 2-oxoglutarate reductase.