1.1.1.3: homoserine dehydrogenase

This is an abbreviated version!
For detailed information about homoserine dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.3

1.1.1.3

l-threonine

threonine-sensitive

corynebacterium

glutamicum

l-lysine

semialdehyde

dihydrodipicolinate

l-isoleucine

brevibacterium

aspartate-derived

2.7.2.4

i-homoserine

rhodospirillum

lysine-sensitive

lactofermentum

feedback-insensitive

feedback-resistant

synthesis

drug development

agriculture

pharmacology

Reaction

Synonyms

AK-HDH, AK-HSD-1, AK-HSDH, AK-HseDH, aspartate kinase-homoserine dehydrogenase, aspartokinase-homoserine dehydrogenase I, bifunctional aspartate kinase-homoserine dehydrogenase, BsHSD, HDH, hom, hom-1, Hom6, homoserine dehydrogenase 1, homoserine dehydrogenase 2, HSD, HSDH, HseDH, More, orf19.2951, PbHSD, SACOL1362, StHSD, thrA, TM_0547, TTHA0489, TtHSD

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.3 homoserine dehydrogenase

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Results	in table
3	Activating Compound
46611	AA Sequence
13	Application
1	CAS Registry Number
20	Cloned(Commentary)
72	Cofactor
8	Crystallization (Commentary)
4	Expression
67	General Information
4	IC50 Value
111	Inhibitors
35	kcat/KM [mM/s]
7	Ki Value [mM]
88	KM Value [mM]
10	Localization
26	Metals/Ions
33	Molecular Weight [Da]
61	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
92	Organism
9	Pathway
50	PDB ID
16	pH Optimum
3	pH Range
2	pH Stability
2	Posttranslational Modification
54	Protein Variants
28	Purification (Commentary)
13	Reaction
3	Reaction Type
87	Reference
1	Renatured (Commentary)
16	Source Tissue
15	Specific Activity [micromol/min/mg]
4	Storage Stability
122	Substrates and Products (Substrate)
34	Subunits
101	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
3	Temperature Range [°C]
9	Temperature Stability [°C]
25	Turnover Number [1/s]

KI Value

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KI Value on EC 1.1.1.3 - homoserine dehydrogenase

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0.0131

(2S)-2-[[4-(propan-2-yl)phenyl]sulfanyl]propanenitrile

Mycobacterium leprae

P46806

pH and temperature not specified in the publication

740548

0.01307

1-tert-butyl-4-[(difluoromethyl)sulfanyl]benzene

Mycobacterium leprae

P46806

pH and temperature not specified in the publication

740548

0.00963

1-[(1S,2S)-2-(bromomethyl)cyclopropyl]-4-[(trifluoromethyl)sulfanyl]benzene

Mycobacterium leprae

P46806

pH and temperature not specified in the publication

740548

0.01568

3-[(4-tert-butylphenyl)sulfanyl]propane-1-thiol

Mycobacterium leprae

P46806

pH and temperature not specified in the publication

740548

0.01

4-(4-hydroxy-3-isopropylphenylthio)-2-isopropylphenol

Mycobacterium leprae

P46806

pH and temperature not specified in the publication

740548

160 - 240

L-threonine

Glycine max

O63067, O65027, Q3S3F6

pH 8.0, 25°C

712490

0.0000052

NADP+

Pyrococcus horikoshii

O58802

pH 9.0, 50°C, recombinant wild-type enzyme

741408