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1.1.1.304: diacetyl reductase [(S)-acetoin forming]

This is an abbreviated version!
For detailed information about diacetyl reductase [(S)-acetoin forming], go to the full flat file.

Word Map on EC 1.1.1.304

Reaction

(S)-acetoin
+
NAD+
=
diacetyl
+
NADH
+
H+

Synonyms

acetoin(diacetyl) reductase, ADH, AdR, ADS1, ardII, BSDR, budC, DAR, diacetyl reductase, EC 1.1.1.5, FQU75_06005, Kp-BudC, Kpdar, NADH-dependent Kp-BudC, Ppdar, ReADR, S-stereospecific diacetyl reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.304 diacetyl reductase [(S)-acetoin forming]

Inhibitors

Inhibitors on EC 1.1.1.304 - diacetyl reductase [(S)-acetoin forming]

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-oxoglutarate
-
noncompetitive
acetoin
-
noncompetitive, product inhibition
acetone
-
competitive for diacetyl, uncompetitive for NADH
Ag+
-
1 mM, 0.5% of initial activity with substrate diacetyl, 0.5% with substrate 2,3-butanediol, respectively
Cu2+
-
1 mM, 0.2% of initial activity with substrate diacetyl, 1% with substrate 2,3-butanediol, respectively
diacetyl
-
substrate inhibition at concentrations above 80-90 mM
EDTA
-
1 mM, 91% of initial activity with substrate diacetyl, 90% with substrate 2,3-butanediol, respectively
ethyl pyruvate
-
substrate inhibition at concentrations above 80-90 mM
Fe2+
inhibits 91.6% at 2 mM
Fe3+
-
1 mM, 2% of initial activity with substrate diacetyl, 3.5% with substrate 2,3-butanediol, respectively
hexane-2,5-dione
-
noncompetitive
Methyl pyruvate
-
substrate inhibition at concentrations above 80-90 mM
NAD+
-
competitive, product inhibition
Pentane-3-one
-
competitive for diacetyl, uncompetitive for NADH