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1.1.1.312: 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase

This is an abbreviated version!
For detailed information about 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.312

Reaction

4-carboxy-2-hydroxymuconate semialdehyde hemiacetal
+
NADP+
=
2-oxo-2H-pyran-4,6-dicarboxylate
+
NADPH
+
H+

Synonyms

2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 2-hydroxy-4-carboxymuconate-6-semialdehyde dehydrogenase, 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ oxidoreductase, 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase, alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase, CHMS dehydrogenase, CHMS hydrolase, dehydrogenase, 2-hydroxy-4-carboxymuconate 6-semialdehyde, EC 1.2.1.45, PmdC

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.312 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.312 - 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-pyrone-4,6-dicarboxylic acid
-
non-competitive inhibition with respect to 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde
5,5'-dithiobis(2-nitrobenzoate)
-
1 h at 0.1 mM inhibits 98% of enzyme activity
Blue dextran
-
competitive inhibitor with respect to NADP+
-
HgCl2
methoxy Reactive Blue 2
-
inhibits the enzyme non-competitively with respect to 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde and competitively with respect to NADP+
Monoiodoacetic acid
-
weaker inhibitor than p-chloromercuribenzoate or HgCl2
N-ethylmaleimide
-
weaker inhibitor than p-chloromercuribenzoate or HgCl2
NADH
-
competitive inhibition with respect to NAD+, non-competitive inhibition with respect to 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde
NADPH
-
competitive inhibition with respect to NADP, non-competitive inhibition with respect to 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde
p-chloromercuribenzoate
Reactive blue 2
-
inhibits the enzyme non-competitively with respect to 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde and competitively with respect to NADP+
Reactive Blue 4
-
inhibits the enzyme non-competitively with respect to 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde and competitively with respect to NADP+
additional information
-
not: various metal ions, metal chelating reagents, reducing reagents
-