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1.1.1.34: hydroxymethylglutaryl-CoA reductase (NADPH)

This is an abbreviated version!
For detailed information about hydroxymethylglutaryl-CoA reductase (NADPH), go to the full flat file.

Word Map on EC 1.1.1.34

Reaction

(R)-mevalonate
+
CoA
 + 2 NADP+ =
(S)-3-hydroxy-3-methylglutaryl-CoA
 + 2 NADPH + 2 H+

Synonyms

3-hydroxy-3-methyl-glutaryl CoA reductase, 3-hydroxy-3-methylglutaryl Ccoenzyme A reductase 1, 3-hydroxy-3-methylglutaryl co-enzyme A reductase, 3-hydroxy-3-methylglutaryl CoA reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase 1, 3-hydroxy-3-methylglutaryl-CoA reductase, 3-hydroxy-3-methylglutaryl-CoA reductase (NADPH), 3-hydroxy-3-methylglutaryl-CoA reductase 1, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase 5, 3-hydroxy-3-metylglutaryl coenzyme A reductase, 3-hydroxymethylglutaryl coenzyme A reductase, acetoacetyl-coenzyme A thiolase/3-hydroxy-3-methylglutaryl-coenzyme A reductase, beta-hydroxy-beta-methylglutaryl coenzyme A reductase, beta-hydroxy-beta-methylglutaryl-Co A reductase, EuHMGR, HMG CoA reductase, HMG-CoA reductase, HMG-CoA-R, HMG-CoAR, HMG1, HMG2, HMG2.2, Hmg2p, HMG3.3, HMGCoA reductase, HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating CoA), HMGCoAR, HMGCR, HMGCR1, HMGR, HMGR1, HMGR1S, HMGR2, HMGR3, HMGR5, hydroxy-3-methylglutoryl-Coenzyme A reductase, hydroxymethylglutaryl CoA reductase (NADPH), hydroxymethylglutaryl-coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate), mevalonate:NADP+ oxidoreductase (acetylating CoA), microsomal HMG-CoA reductase, NADPH-hydroxymethylglutaryl-CoA reductase, S-3-hydroxy-3-methylglutaryl-CoA reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)

Specific Activity

Specific Activity on EC 1.1.1.34 - hydroxymethylglutaryl-CoA reductase (NADPH)

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0006
about, native cells
0.01333
mutant enzyme S577A from transgenic line 2, at 30°C, pH not specified in the publication
0.01644
mutant enzyme S577A from transgenic line 1, at 30°C, pH not specified in the publication
0.01949
wild type enzyme from transgenic line 1, at 30°C, pH not specified in the publication
0.03568
wild type enzyme from transgenic line 2, at 30°C, not pH not specified in the publication
0.69
-
native enzyme in cell extract soluble fraction
17.5
50°C, pH 5.5, recombinant enzyme
28
-
purified recombinant enzyme
3.9
-
50°C, mutant L403R/G404R/A406S
60
recombinant Sf9 cells
7800
-
purified enzyme
additional information
-
-