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1.1.1.357: 3alpha-hydroxysteroid 3-dehydrogenase

This is an abbreviated version!
For detailed information about 3alpha-hydroxysteroid 3-dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.357

Reaction

a 3alpha-hydroxysteroid
+
NAD(P)+
=
a 3-oxosteroid
+
NAD(P)H
+
H+

Synonyms

17beta-HSD5, 3-alpha hydroxysteroid dehydrogenase type 3, 3-alpha-HSD type 2, 3-alpha-HSD1, 3-alpha-hydroxysteroid dehydrogenase type 2, 3-alpha-hydroxysteroid dehydrogenase type I, 3alpha-HSD, 3alpha-HSD type III, 3alpha-HSD/CR, 3alpha-HSD3, 3alpha-HSOR, 3alpha-hydroxysteroid dehydrogenase, 3alpha-hydroxysteroid dehydrogenase type 3, 3alpha-hydroxysteroid dehydrogenase type III, 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase, 3alpha-hydroxysteroid oxidoreductase, AKR1C1, AKR1C14, AKR1C2, AKR1C3, AKR1C33, AKR1C4, AKR1C9, aldo-keto reductase family 1 member C1, aldo-keto reductase family 1 member C2, aldo-keto reductase family 1 member C3, bile acid binding protein, chlordecone reductase, DD2, DD4, dihydrodiol dehydrogenase, dihydrodiol dehydrogenase 4, dihydrodiol/3alpha-hydroxysteroid dehydrogenase, HSD 28, HSD 29, hsdA, More, NADPH-dependent AKR1C9, Naloxone reductase 2, Ps3alphaHSD, type 1 3alpha-HSD, type 3 3alpha-hydroxysteroid dehydrogenase, type 5 17beta-hydroxysteroid dehydrogenase, type I 3alpha-HSD, type III 3-alpha-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.357 3alpha-hydroxysteroid 3-dehydrogenase

Turnover Number

Turnover Number on EC 1.1.1.357 - 3alpha-hydroxysteroid 3-dehydrogenase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.18 - 0.77
(R)-tetralol
0.2 - 0.27
(S)-1,2,3,4-tetrahydronaphth-1-ol
0.1 - 0.4
(S)-indan-1-ol
0.2 - 0.43
(S)-tetralol
0.91 - 4.3
2-decalol
0.035
3alpha-androstanediol
isoform AKR1C4, at pH 7.4 and 25°C
0.0038
4-androstenedione
pH 7.4, 37°C
0.0052 - 0.032
4-hydroxyandrostenedione
-
0.0078 - 0.025
4-hydroxytestosterone
-
0.004 - 0.367
5alpha-androstan-17-beta-ol-3-one
0.007
5alpha-Androstan-3alpha-ol-17-one
0.03
5alpha-androstane-3,17-dione
isoform AKR1C4, at pH 7.4 and 25°C
0.087 - 0.35
5alpha-androstane-3alpha,17beta-diol
0.003
5alpha-dihydroprogesterone
in 100 mM potassium phosphate, pH 7.0, at 25°C
0.033 - 0.1153
5alpha-dihydrotestosterone
0.0025 - 0.05
5alpha-pregnan-20alpha-ol-3-one
0.009 - 0.14
5beta-androstan-3,17-dione
0.004 - 0.18
5beta-Androstan-3alpha-ol-17-one
0.047 - 0.3
5beta-androstane-3alpha,17beta-diol
0.007 - 0.053
5beta-pregnane-3,20-dione
0.002 - 0.003
5beta-pregnane-3alpha,20alpha-diol
0.083 - 0.42
9alpha,11beta-prostaglandin F2
0.000017
allopregnanolone
in 100 mM potassium phosphate, pH 7.0, at 25°C
230
androstenol
reombinant His-tagged enzyme, pH 10.5, 25°C
0.023 - 500
androsterone
0.032 - 0.13
chenodeoxycholic acid
0.012 - 23
cholic acid
0.74 - 2.5
Cyclohexanol
0.89 - 48
Dehydrocholic acid
0.006 - 0.037
Dehydrolithocholic acid
0.012 - 0.085
deoxycholic acid
0.00075 - 0.026
dihydrotestosterone
0.032 - 0.043
lithocholic acid
0.2 - 0.58
NAD+
0.006 - 0.85
NADP+
0.01 - 0.1
NADPH
0.0035 - 0.0392
pregn-4-en-3,20-dione
0.032
testosterone
pH 7.4, 37°C
additional information
additional information
Kcat-value for the 17beta-oxidation of testosterone is 0.000118 1/sec, and Kcat-value for the 17beta-reduction of androstenedione is 0.00112 1/sec
-