1.1.1.362: aklaviketone reductase

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For detailed information about aklaviketone reductase, go to the full flat file.

Reaction

Synonyms

DauE

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.362 aklaviketone reductase

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Results	in table
38	AA Sequence
1	Cloned(Commentary)
1	Cofactor
1	General Information
1	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
1	Organism
7	Pathway
1	Reaction
1	Reference
4	Substrates and Products (Substrate)
1	Subunits
1	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 1.1.1.362 - aklaviketone reductase

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SYSTEMATIC NAME

IUBMB Comments

aklavinone:NADP+ oxidoreductase

The enzyme is involved in the synthesis of the aklavinone aglycone, a common precursor for several anthracycline antibiotics including aclacinomycins, daunorubicin and doxorubicin. The enzyme from the Gram-negative bacterium Streptomyces sp. C5 produces daunomycin.