1.1.1.368: 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase
This is an abbreviated version!
For detailed information about 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase, go to the full flat file.
Reaction
Synonyms
HAD, ThaADH
ECTree
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Substrates Products
Substrates Products on EC 1.1.1.368 - 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase
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REACTION DIAGRAM
6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD+
6-oxocyclohex-1-ene-1-carbonyl-CoA + NADH + H+
additional information
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the enzyme exhibits a substrate specificity with highest activities on cyclic alpha- and beta-diketones including 1,2-cyclohexanedione and 1,3-cyclopentanedione, enzyme activity with 1,2-cyclohexanedione, 1,3-cyclohexanedione, and 1,3-cyclopentanedione as well as with 2,3/pentanedione, ethyl pyruvate, and cyclohexanone, but ThaADH converts neither acetophenone nor benzaldehyde which are both preferred substrates of many known zinc-dependent ADHs. The enzyme actually prefers substrates with the reactive carbonyl function being located inside a cyclohexyl or cyclopentyl structure
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6-oxocyclohex-1-ene-1-carbonyl-CoA + NADH + H+
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6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD+
6-oxocyclohex-1-ene-1-carbonyl-CoA + NADH + H+
the enzyme participates in the central benzoyl-CoA degradation pathway of some anaerobic bacteria
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6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD+
6-oxocyclohex-1-ene-1-carbonyl-CoA + NADH + H+
the enzyme is specific for NAD+, no activity with NADP+. The enzyme is specific for 6-hydroxycyclohex-1-ene-1-carbonyl-CoA, no activity with 2-hydroxycyclohexane-1-carbonyl-CoA
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