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1.1.1.392: 3alpha-hydroxycholanate dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about 3alpha-hydroxycholanate dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.1.1.392

Reaction

lithocholate
+
NADP+
=
3-oxo-5beta-cholan-24-oate
+
NADPH
+
H+

Synonyms

3alpha-HSDH, alpha-hydroxy-cholanate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.392 3alpha-hydroxycholanate dehydrogenase (NADP+)

Systematic Name

Systematic Name on EC 1.1.1.392 - 3alpha-hydroxycholanate dehydrogenase (NADP+)

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SYSTEMATIC NAME
IUBMB Comments
lithocholate:NADP+ 3-oxidoreductase
This bacterial enzyme is involved in the modification of secondary bile acids to form 3beta-bile acids (also known as iso-bile acids) via a 3-oxo intermediate. The enzyme catalyses a reversible reaction in vitro. Also acts on related bile acids. cf. EC 1.1.1.52, 3alpha-hydroxycholanate dehydrogenase (NAD+).