1.1.1.4: (R,R)-butanediol dehydrogenase
This is an abbreviated version!
For detailed information about (R,R)-butanediol dehydrogenase, go to the full flat file.
Reaction
+
=
+
+
Synonyms
(2R,3R)-2,3-BDH, (2R,3R)-2,3-butanediol dehydrogenase, (R)-2,3-butanediol dehydrogenase, (R)-diacetyl reductase, (R,R)-butane-2,3-diol dehydrogenase, 1-amino-2-propanol dehydrogenase, 1-amino-2-propanol oxidoreductase, 2,3-BDH/AR, 2,3-butanediol dehydrogenase, 2,3-butanediol dehydrogenase/acetoin reductase, 2R,3R-2,3-BD dehydrogenase, 2R-3R-BDH, acetoin reductase, acetoin/diacetyl reductase, ADH-9, aminopropanol oxidoreductase, AR/BDH, BaBdhA, BcBDH, BDH, BDH1, Bdh1p, BDH2, Bdh2p, BDH99::67, BdhA, BtBDH, ButA, butanediol dehydrogenase, ButB, butylene glycol dehydrogenase, butyleneglycol dehydrogenase, D-(-)-butanediol dehydrogenase, D-1-amino-2-propanol dehydrogenase, D-1-amino-2-propanol:NAD+ oxidoreductase, D-2,3-BD dehydrogenase, D-aminopropanol dehydrogenase, dehydrogenase, D-aminopropanol, dehydrogenase, D-butanediol, DHAD, diacetyl reductase (acetoin), EC 1.1.1.74, GDH, GldA, meso-2,3-butanediol dehydrogenase, meso-BDH, MF996569, More, NAD(H)-dependent 2,3-butanediol dehydrogenase, NADH-dependent 2,3-butanediol dehydrogenase, PA4153, PB24_3312, R,R-2,3-butanediol dehydrogenase/meso-2,3-butanediol dehydrogenase/diacetyl reductase, R,R-BD-DH, R,R-BDH, R-selective 2,3-butanediol dehydrogenase, SLAC
ECTree
KM Value
KM Value on EC 1.1.1.4 - (R,R)-butanediol dehydrogenase
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14 - 65
(2R,3R)-2,3-butanediol
0.057 - 236.4
(2R,3R)-butane-2,3-diol
3.67
(2R,3S)-butane-2,3-diol
pH 10.0, 50°C, recombinant enzyme
0.23
(2S)-acetoin
-
at pH 10.5 and 30°C
0.052
(2S,3S)-butane-2,3-diol
-
at pH 10.5 and 30°C
0.06 - 4.5
(3R,3S)-acetoin
4.15 - 12.06
(3R,3S)-butane-2,3-diol
2.01 - 6.01
(R,R)-butane-2,3-diol
14.5
1-hydroxy-2-propanone
-
-
2.6 - 86.8
2,3-Butanediol
1
2-hydroxyacetophenone
pH 7.0, 25°C, recombinant His-tagged enzyme
0.65 - 20.18
acetaldehyde
1.2
Butanone
pH 7.5, 25°C
3.3
D-(-)2,3-butanediol
-
-
9.38 - 29.42
glycolaldehyde
6.25
meso-2,3-butanediol
-
-
2.73 - 37.39
meso-butane-2,3-diol
additional information
additional information
Michaelis-Menten kinetics
-
14
(2R,3R)-2,3-butanediol
-
-
65
(2R,3R)-2,3-butanediol
pH 7.5, 25°C
0.057
(2R,3R)-butane-2,3-diol
pH 7.4, 30°C
0.58
(2R,3R)-butane-2,3-diol
at pH 6.5 and 55°C
0.76
(2R,3R)-butane-2,3-diol
pH 10.0, 50°C, recombinant enzyme
1.76
(2R,3R)-butane-2,3-diol
pH 11.0, 22°C
7.67
(2R,3R)-butane-2,3-diol
-
pH 7.0, 30°C
119.3
(2R,3R)-butane-2,3-diol
-
enzyme GldA, at pH 9.0 and 30°C
236.4
(2R,3R)-butane-2,3-diol
-
enzyme DhaD, at pH 9.0 and 30°C
0.06
(3R,3S)-acetoin
pH 7.0, 30°C
0.2
(3R,3S)-acetoin
-
pH 7.0, 30°C
0.3
(3R,3S)-acetoin
pH 8.0, 22°C
4.15
(3R,3S)-butane-2,3-diol
-
enzyme GldA, at pH 9.0 and 30°C
12.06
(3R,3S)-butane-2,3-diol
-
enzyme DhaD, at pH 9.0 and 30°C
0.12
(R)-acetoin
at pH 6.0 and 50°C
1.49
(R)-acetoin
-
at pH 7.0 and 30°C
3
(R)-acetoin
wild type enzyme
33
(R)-acetoin
mutant enzyme E221S/I222R/A223S
34
(R)-acetoin
mutant S199R, pH 7.5, 25°C
45
(R)-acetoin
mutant S199C, pH 7.5, 25°C
77
(R)-acetoin
mutant enzyme E221S/I222R
98
(R)-acetoin
wild-type, pH 7.5, 25°C
120
(R)-acetoin
mutant S199A, pH 7.5, 25°C
161
(R)-acetoin
mutant enzyme E221S
190
(R)-acetoin
mutant S199W, pH 7.5, 25°C
230
(R)-acetoin
mutant S199G, pH 7.5, 25°C
2.01
(R,R)-butane-2,3-diol
-
at pH 10.5 and 30°C
6.01
(R,R)-butane-2,3-diol
at pH 9.0 and 50°C
2.6
2,3-Butanediol
-
-
0.8
2-butanone
mutant S199A, pH 7.5, 25°C
1.5
2-butanone
mutant S199C, pH 7.5, 25°C
1.8
2-butanone
wild-type, pH 7.5, 25°C
1.9
2-butanone
mutant S199R, pH 7.5, 25°C
2.4
2-butanone
mutant S199G, pH 7.5, 25°C
3.6
2-butanone
mutant S199W, pH 7.5, 25°C
0.65
acetaldehyde
recombinant enzyme, pH 7.0, 30°C, with NADH, from strain B
0.67
acetaldehyde
recombinant enzyme, pH 7.0, 30°C, with NADH, from strain B
4.49
acetaldehyde
recombinant enzyme, pH 7.0, 30°C, with NADH, from strain Y
5.5
acetaldehyde
pH 7.5, 25°C
20.18
acetaldehyde
recombinant enzyme, pH 7.0, 30°C, with NADH, from strain Y
0.4
acetoin
-
-
0.84
acetoin
-
(S)-acetoin, pH 7.0, 30°C
3.4
acetoin
-
cosubstrate NADH, pH 7.0, temperature not specified in the publication
13.6
acetoin
-
cosubstrate NADPH, pH 7.0, temperature not specified in the publication
0.6
acetone
pH 7.5, 25°C
0.9
acetone
mutant S199A, pH 7.5, 25°C
1
acetone
wild-type, pH 7.5, 25°C
1.1
acetone
mutant S199R, pH 7.5, 25°C
1.2
acetone
mutant S199C, pH 7.5, 25°C
1.6
acetone
mutant S199G, pH 7.5, 25°C
2
acetone
mutant S199W, pH 7.5, 25°C
0.1
diacetyl
at pH 10.0 and 45°C
0.13
diacetyl
at pH 6.0 and 50°C
14.49
glycerol
-
enzyme GldA, at pH 9.0 and 30°C
93.62
glycerol
-
enzyme DhaD, at pH 9.0 and 30°C
9.38
glycolaldehyde
recombinant enzyme, pH 7.0, 30°C, with NADH, from strain Y
15.52
glycolaldehyde
recombinant enzyme, pH 7.0, 30°C, with NADH, from strain Y
17.91
glycolaldehyde
recombinant enzyme, pH 7.0, 30°C, with NADH, from strain B
29.42
glycolaldehyde
recombinant enzyme, pH 7.0, 30°C, with NADH, from strain B
2.73
meso-butane-2,3-diol
-
pH 7.0, 30°C
4.94
meso-butane-2,3-diol
-
enzyme GldA, at pH 9.0 and 30°C
5.62
meso-butane-2,3-diol
pH 11.0, 22°C
6.38
meso-butane-2,3-diol
at pH 9.0 and 50°C
37.39
meso-butane-2,3-diol
-
enzyme DhaD, at pH 9.0 and 30°C
0.16
NAD+
-
-
1.04
NAD+
with (2R,3R)-butane-2,3-diol as cosubstrate, at pH 6.5 and 55°C
0.045
NADH
wild type enzyme
0.08
NADH
with diacetyl as cosubstrate, at pH 10.0 and 45°C
0.7
NADH
mutant enzyme E221S
0.0017
NADPH
wild-type, pH 7.5, 25°C
0.0056
NADPH
mutant S199A, pH 7.5, 25°C
0.036
NADPH
mutant S199R, pH 7.5, 25°C
0.044
NADPH
mutant enzyme E221S/I222R
0.044
NADPH
mutant enzyme E221S/I222R/A223S
0.087
NADPH
mutant enzyme E221S