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1.1.1.51: 3(or 17)beta-hydroxysteroid dehydrogenase

This is an abbreviated version!
For detailed information about 3(or 17)beta-hydroxysteroid dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.51

Reaction

testosterone
+
NAD(P)+
=
androstenedione
 +
NAD(P)H
 +
H+

Synonyms

17 beta-HSD3, 17 beta-hydroxysteroid dehydrogenase, 17-beta-HSD, 17-ketoreductase, 17beta-HSD, 17beta-HSD (type 1), 17beta-HSD (type 3), 17beta-HSD type 2, 17beta-HSD type 3, 17beta-HSD type II, 17beta-HSD-3, 17beta-HSD1, 17beta-HSD2, 17beta-HSD3, 17beta-HSD5, 17beta-HSD7_2, 17beta-HSOR, 17beta-hydroxy steroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase 2, 17beta-hydroxysteroid dehydrogenase type 1, 17beta-hydroxysteroid dehydrogenase type 3, 17beta-hydroxysteroid dehydrogenases, 17beta-hydroxysteroid dehydrogenases type 2, 17beta-hydroxysteroid oxidoreductase, 17beta-hydroxysteroid: NADP 17-oxidoreductase, 17betaHSD2, 3 beta-hydroxysteroid dehydrogenase, 3,17beta-HSD, 3,17beta-hydroxysteroid dehydrogenase, 3-beta HSD, 3beta,17beta-hydroxysteroid dehydrogenase, 3beta-HSD, 3beta-HSD (type 1), 3beta-HSD type-I, 3beta-HSD type-II, 3beta-HSD/isomerase, 3beta-hydroxy steroid dehydrogenase, 3beta-hydroxy-steroid dehydrogenase/DELTA5-DELTA4 isomerase, 3beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase/DELTA5-4-isomerase, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase, 3beta-hydroxysteroid dehydrogenase/isomerase, 3beta-hydroxystroid oxidoreductase, 3beta/17beta-HSD, 3beta/17beta-hydroxysteroid dehydrogenase, 3beta17betaHSDH, 3betaHSD, AKR1C3, AKR1C35, aldo keto reductase 1C3, beta-hydroxy steroid dehydrogenase, betahsd, dehydrogenase, 17beta-hydroxy steroid, dehydrogenase, 3beta-hydroxy steroid, dehydrogenase, beta-hydroxy steroid, DELTA5-3beta-HSD, DELTA5-3beta-hydroxysteroid dehydrogenase, form 2 type 7 17beta-hydroxysteroid dehydrogenase, HSD, HSD17B1, HSD17B3, LOC101842245, More, pQ3 beta HSD, RDH11, Rdh11/12-like 1, Rdh11/12-like 2, Rdh11/12-like 3, retinol dehydrogenases 11-like, steroid 17beta-reductase, type 17beta-HSD, type 2 17beta-HSD, type 3 17beta-HSD, type 3 17beta-hydroxysteroid dehydrogenase, type 5 17-beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase

Reference

topprint

Reference on EC 1.1.1.51 - 3(or 17)beta-hydroxysteroid dehydrogenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dahm, K.; Breuer, H.
Anreicherung einer 17beta-hydroxysteroid: NAD(P)-Oxydoreduktase aus der Nebenniere der Ratte
Hoppe-Seyler's Z. Physiol. Chem.
336
63-68
1964
Rattus norvegicus, Rattus norvegicus Wistar
-
Manually annotated by BRENDA team
Mulder, E.; Lamers-Stahlhofen, G.J.M.; van der Molen, H.J.
Isolation and characterization of 17beta-hydroxy steroid dehydrogenase from human erythrocytes
Biochem. J.
127
649-659
1972
Homo sapiens
Manually annotated by BRENDA team
Heyns, W.; de Moor, P.
A 3(17)beta-hydroxysteroid dehydrogenase in rat erythrocytes. Conversion of 5alpha-dihydrotestosterone into 5alpha-androstane-3beta,17beta-diol and purification of the enzyme by affinity chromatography
Biochim. Biophys. Acta
358
1-13
1974
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Schultz, R.M.; Groman, E.V.; Engel, L.L.
3(17)beta-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. Ligand binding properties
J. Biol. Chem.
252
3784-3790
1977
Comamonas testosteroni
Manually annotated by BRENDA team
Schultz, R.M.; Groman, E.V.; Engel, L.L.
3(17)beta-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms
J. Biol. Chem.
252
3775-3783
1977
Comamonas testosteroni
Manually annotated by BRENDA team
Shen, C.C.; Kochakian, C.D.
The induction, purification and characterization of 17beta-hydroxy-C19-steroid dehydrogenase of the female guinea pig kidney
J. Steroid Biochem.
10
187-193
1979
Cavia porcellus
Manually annotated by BRENDA team
Kwan, T.K.; Gower, D.B.
Kinetic studies of 3alpha- and 3beta-hydroxysteroid dehydrogenase in neonatal porcine testis subcellular fractions
Biochem. Soc. Trans.
12
842-843
1984
Sus scrofa
-
Manually annotated by BRENDA team
Minard, P.; Legoy, M.D.; Thomas, D.
3beta, 17beta-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. Kinetic evidence for the bifunctional activity at a common catalytic site
FEBS Lett.
188
85-90
1985
Comamonas testosteroni
Manually annotated by BRENDA team
Stokes, N.A.; Hylemon, P.B.
Characterization of DELTA4-3-ketosteroid-5beta-reductase and 3beta-hydroxysteroid dehydrogenase in cell extracts of Clostridium innocuum
Biochim. Biophys. Acta
836
255-261
1985
[Clostridium] innocuum
Manually annotated by BRENDA team
Benach, J.; Knapp, S.; Oppermann, UC.; Hagglund, O.; Jornvall, H.; Ladenstein, R.
Crystallization and crystal packing of recombinant 3 (or 17) beta-hydroxysteroid dehydrogenase from Comamonas testosteroni ATTC 11996
Eur. J. Biochem.
236
144-148
1996
Comamonas testosteroni, Comamonas testosteroni ATTC 11996
Manually annotated by BRENDA team
Stevenson, D.; Kochakian, C.D.
Purification of male guinea pig kidney 17beta-hydroxy-C19-steroid dehydrogenase
Endocrinology
95
766-770
1974
Cavia porcellus
Manually annotated by BRENDA team
Khan, N.; Sharma, K.K.; Andersson, S.; Auchus, R.J.
Human 17beta-hydroxysteroid dehydrogenases types 1, 2, and 3 catalyze bi-directional equilibrium reactions, rather than unidirectional metabolism, in HEK-293 cells
Arch. Biochem. Biophys.
429
50-59
2004
Homo sapiens
Manually annotated by BRENDA team
Benach, J.; Filling, C.; Oppermann, U.C.; Roversi, P.; Bricogne, G.; Berndt, K.D.; Jornvall, H.; Ladenstein, R.
Structure of bacterial 3beta/17beta-hydroxysteroid dehydrogenase at 1.2 A resolution: a model for multiple steroid recognition
Biochemistry
41
14659-14668
2002
Comamonas testosteroni (P19871), Comamonas testosteroni
Manually annotated by BRENDA team
Poirier, D.
Inhibitors of 17beta-hydroxysteroid dehydrogenases
Curr. Med. Chem.
10
453-477
2003
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Lu, M.L.; Huang, Y.W.; Lin, S.X.
Purification, reconstitution, and steady-state kinetics of the trans-membrane 17beta-hydroxysteroid dehydrogenase 2
J. Biol. Chem.
277
22123-22130
2002
Homo sapiens
Manually annotated by BRENDA team
Tchedam Ngatcha, B.; Luu-The, V.; Labrie, F.; Poirier, D.
Androsterone 3alpha-ether-3beta-substituted and androsterone 3beta-substituted derivatives as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase: chemical synthesis and structure-activity relationship
J. Med. Chem.
48
5257-5268
2005
Homo sapiens
Manually annotated by BRENDA team
Mindnich, R.; Haller, F.; Halbach, F.; Moeller, G.; Hrabe de Angelis, M.; Adamski, J.
Androgen metabolism via 17beta-hydroxysteroid dehydrogenase type 3 in mammalian and non-mammalian vertebrates: comparison of the human and the zebrafish enzyme
J. Mol. Endocrinol.
35
305-316
2005
Danio rerio (Q6QA32), Danio rerio, Homo sapiens
Manually annotated by BRENDA team
Liu, H.; Robert, A.; Luu-The, V.
Cloning and characterization of human form 2 type 7 17beta-hydroxysteroid dehydrogenase, a primarily 3beta-keto reductase and estrogen activating and androgen inactivating enzyme
J. Steroid Biochem. Mol. Biol.
94
173-179
2005
Homo sapiens
Manually annotated by BRENDA team
Durocher, F.; Sanchez, R.; Ricketts, M.L.; Labrie, Y.; Laudet, V.; Simard, J.
Characterization of the guinea pig 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase expressed in the adrenal gland and gonads
J. Steroid Biochem. Mol. Biol.
97
289-298
2005
Cavia porcellus
Manually annotated by BRENDA team
Ngatcha, B.T.; Laplante, Y.; Labrie, F.; Luu-The, V.; Poirier, D.
3beta-Alkyl-androsterones as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase: inhibitory potency in intact cells, selectivity towards isoforms 1, 2, 5 and 7, binding affinity for steroid receptors, and proliferative/antiproliferative activities on AR+ and ER+ cell lines
Mol. Cell. Endocrinol.
248
225-232
2006
Homo sapiens
Manually annotated by BRENDA team
Luu-The, V.; Tremblay, P.; Labrie, F.
Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women
Mol. Endocrinol.
20
437-443
2006
Homo sapiens
Manually annotated by BRENDA team
Fink, B.E.; Gavai, A.V.; Tokarski, J.S.; Goyal, B.; Misra, R.; Xiao, H.; Kimball, S.D.; Han, W.; Norris, D.; Spires, T.E.; You, D.; Gottardis, M.M.; Lorenzi, M.V.; Vite, G.D.
Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17beta-hydroxysteroid dehydrogenase type 3
Bioorg. Med. Chem. Lett.
16
1532-1536
2006
Homo sapiens
Manually annotated by BRENDA team
Degtyar, V.G.; Babkina, T.V.; Kazantseva, I.A.; Morozov, A.P.; Trapeznikova, M.F.; Kushlinskii, N.E.
Reductase activity of 17beta-hydroxysteroid oxidoreductase in prostatic tumors of different histological structure
Bull. Exp. Biol. Med.
139
715-717
2005
Homo sapiens
Manually annotated by BRENDA team
Ulrih, N.P.; Lanisnik Rizner, T.
Conformational stability of 17 beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus
FEBS J.
273
3927-3937
2006
Curvularia lunata
Manually annotated by BRENDA team
Zhou, L.Y.; Wang, D.S.; Senthilkumaran, B.; Yoshikuni, M.; Shibata, Y.; Kobayashi, T.; Sudhakumari, C.C.; Nagahama, Y.
Cloning, expression and characterization of three types of 17beta-hydroxysteroid dehydrogenases from the Nile tilapia, Oreochromis niloticus
J. Mol. Endocrinol.
35
103-116
2005
Oreochromis niloticus
Manually annotated by BRENDA team
Lukacik, P.; Kavanagh, K.L.; Oppermann, U.
Structure and function of human 17beta-hydroxysteroid dehydrogenases
Mol. Cell. Endocrinol.
248
61-71
2006
Homo sapiens
Manually annotated by BRENDA team
Chapman, J.C.; Polanco, J.R.; Min, S.; Michael, S.D.
Mitochondrial 3 beta-hydroxysteroid dehydrogenase (HSD) is essential for the synthesis of progesterone by corpora lutea: an hypothesis
Reprod. Biol. Endocrinol.
3
11
2005
Mus musculus
Manually annotated by BRENDA team
Aizawa, K.; Iemitsu, M.; Maeda, S.; Jesmin, S.; Otsuki, T.; Mowa, C.N.; Miyauchi, T.; Mesaki, N.
Expression of steroidogenic enzymes and synthesis of sex steroid hormones from DHEA in skeletal muscle of rats
Am. J. Physiol.
292
E577-E584
2007
Rattus norvegicus
Manually annotated by BRENDA team
Arukwe, A.; Nordtug, T.; Kortner, T.M.; Mortensen, A.S.; Brakstad, O.G.
Modulation of steroidogenesis and xenobiotic biotransformation responses in zebrafish (Danio rerio) exposed to water-soluble fraction of crude oil
Environ. Res.
107
362-370
2008
Danio rerio (Q7ZZC3)
Manually annotated by BRENDA team
Prisco, M.; Liguoro, A.; Ricchiari, L.; Del Giudice, G.; Angelini, F.; Andreuccetti, P.
Immunolocalization of 3beta-HSD and 17beta-HSD in the testis of the spotted ray Torpedo marmorata
Gen. Comp. Endocrinol.
155
157-163
2008
Torpedo marmorata
Manually annotated by BRENDA team
Chen, G.; Bourneuf, E.; Marklund, S.; Zamaratskaia, G.; Madej, A.; Lundstroem, K.
Gene expression of 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase in relation to androstenone, testosterone, and estrone sulphate in gonadally intact male and castrated pigs
J. Anim. Sci.
85
2457-2463
2007
Sus scrofa
Manually annotated by BRENDA team
Luu-The, V.; Ferraris, C.; Duche, D.; Belanger, P.; Leclaire, J.; Labrie, F.
Steroid metabolism and profile of steroidogenic gene expression in Episkin: high similarity with human epidermis
J. Steroid Biochem. Mol. Biol.
107
30-36
2007
Homo sapiens
Manually annotated by BRENDA team
Herl, V.; Frankenstein, J.; Meitinger, N.; Mueller-Uri, F.; Kreis, W.
Delta5-3beta-hydroxysteroid dehydrogenase (3betaHSD) from Digitalis lanata. Heterologous expression and characterisation of the recombinant enzyme
Planta Med.
73
704-710
2007
Digitalis lanata (Q93Y47), Digitalis lanata
Manually annotated by BRENDA team
Parthasarathy, C.; Balasubramanian, K.
Assessment of in vitro effects of metyrapone on Leydig cell steroidogenesis
Steroids
73
328-338
2008
Rattus norvegicus
Manually annotated by BRENDA team
Hunter, A.C.; Coyle, E.; Morse, F.; Dedi, C.; Dodd, H.T.; Koussoroplis, S.J.
Transformation of 5-ene steroids by the fungus Aspergillus tamarii KITA: Mixed molecular fate in lactonization and hydroxylation pathways with identification of a putative 3beta-hydroxy-steroid dehydrogenase/DELTA(5)-DELTA(4) isomerase pathway
Biochim. Biophys. Acta
1791
110-117
2008
Aspergillus tamarii, Aspergillus tamarii KITA
Manually annotated by BRENDA team
Higo, S.; Hojo, Y.; Ishii, H.; Kominami, T.; Nakajima, K.; Poirier, D.; Kimoto, T.; Kawato, S.
Comparison of sex-steroid synthesis between neonatal and adult rat hippocampus
Biochem. Biophys. Res. Commun.
385
62-66
2009
Rattus norvegicus
Manually annotated by BRENDA team
Bruzzone, F.; Rego, J.L.; Luu-The, V.; Pelletier, G.; Vallarino, M.; Vaudry, H.
Immunohistochemical localization and biological activity of 3beta-hydroxysteroid dehydrogenase and 5alpha-reductase in the brain of the frog, Rana esculenta, during development
J. Chem. Neuroanat.
39
35-50
2010
Pelophylax lessonae
Manually annotated by BRENDA team
Senthilkumaran, B.; Sudhakumari, C.C.; Wang, D.S.; Sreenivasulu, G.; Kobayashi, T.; Kobayashi, H.K.; Yoshikuni, M.; Nagahama, Y.
Novel 3beta-hydroxysteroid dehydrogenases from gonads of the Nile tilapia: phylogenetic significance and expression during reproductive cycle
Mol. Cell. Endocrinol.
299
146-152
2009
Oreochromis niloticus (B9UN12), Oreochromis niloticus (B9UN14)
Manually annotated by BRENDA team
Chura, J.C.; Ryu, H.S.; Simard, M.; Poirier, D.; Tremblay, Y.; Brooker, D.C.; Blomquist, C.H.; Argenta, P.A.
Steroid-converting enzymes in human ovarian carcinomas
Mol. Cell. Endocrinol.
301
51-58
2009
Homo sapiens
Manually annotated by BRENDA team
Nashev, L.G.; Schuster, D.; Laggner, C.; Sodha, S.; Langer, T.; Wolber, G.; Odermatt, A.
The UV-filter benzophenone-1 inhibits 17beta-hydroxysteroid dehydrogenase type 3: Virtual screening as a strategy to identify potential endocrine disrupting chemicals
Biochem. Pharmacol.
79
1189-1199
2010
Mus musculus, Rattus norvegicus, Homo sapiens (P37058), Homo sapiens
Manually annotated by BRENDA team
Darvas, B.; Székács, A.; Fónagy, A.; Szécsi, M.; Tóth, I.
Progesterone in Periplaneta americana and Neobellieria bullata adults from the procuticle phase until first progeny production
Gen. Comp. Endocrinol.
107
450-460
1997
Periplaneta americana
Manually annotated by BRENDA team
Tóth, I.; Szécsi, M.; Julesz, J.; Faredin, I.; Behnke, B.
In vitro inhibition of testicular delta 5-3 beta-hydroxysteroid dehydrogenase and prostatic 5 alpha-reductase activities in rats and humans by strogen forte extract
Int. Urol. Nephrol.
28
337-348
1996
Homo sapiens, Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Zhao, B.; Chu, Y.; Hardy, D.O.; Li, X.K.; Ge, R.S.
Inhibition of 3beta- and 17beta-hydroxysteroid dehydrogenase activities in rat Leydig cells by perfluorooctane acid
J. Steroid Biochem. Mol. Biol.
118
13-17
2010
Rattus norvegicus
Manually annotated by BRENDA team
De Catalfo, G.; De Alaniz, M.; Marra, C.
Influence of commercial dietary oils on lipid composition and testosterone production in interstitial cells isolated from rat testis
Lipids
44
345-357
2009
Rattus norvegicus
Manually annotated by BRENDA team
Ernst, M.; de Padua, R.M.; Herl, V.; Mueller-Uri, F.; Kreis, W.
Expression of 3beta-HSD and P5betaR, genes respectively coding for Delta5-3beta-hydroxysteroid dehydrogenase and progesterone 5beta-reductase, in leaves and cell cultures of Digitalis lanata EHRH
Planta Med.
76
923-927
2010
Digitalis lanata (Q93Y47), Digitalis lanata
Manually annotated by BRENDA team
Tóth, I.; Szécsi, M.; Julesz, J.; Faredin I.
Activity and inhibition of 3-beta-hydroxysteroid dehydrogenase/delta-5-4-isomerase in human skin
Skin Pharmacol. Physiol.
10
160-168
1997
Homo sapiens
Manually annotated by BRENDA team
Svegelj, M.B.; Stojan, J.; Rizner, T.L.
The role of Ala231 and Trp227 in the substrate specificities of fungal 17beta-hydroxysteroid dehydrogenase and trihydroxynaphthalene reductase: Steroids versus smaller substrates
J. Steroid Biochem. Mol. Biol.
129
92-98
2012
Curvularia lunata
Manually annotated by BRENDA team
Kenmogne, L.C.; Maltais, R.; Poirier, D.
Synthesis of a dansyl-labeled inhibitor of 17beta-hydroxysteroid dehydrogenase type 3 for optical imaging
Bioorg. Med. Chem. Lett.
26
2179-2183
2016
Homo sapiens
Manually annotated by BRENDA team
Flanagan, J.U.; Atwell, G.J.; Heinrich, D.M.; Brooke, D.G.; Silva, S.; Rigoreau, L.J.; Trivier, E.; Turnbull, A.P.; Raynham, T.; Jamieson, S.M.; Denny, W.A.
Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-beta-hydroxysteroid dehydrogenase (AKR1C3)
Bioorg. Med. Chem.
22
967-977
2014
Homo sapiens (P42330)
Manually annotated by BRENDA team
Yu, Y.; Liu, C.; Wang, B.; Li, Y.; Zhang, H.
Characterization of 3,17beta-hydroxysteroid dehydrogenase in Comamonas testosteroni
Chem. Biol. Interact.
234
221-228
2015
Comamonas testosteroni (P19871), Comamonas testosteroni ATCC 119960 (P19871)
Manually annotated by BRENDA team
Li, M.; Xiong, G.; Maser, E.
A novel transcriptional repressor PhaR for the steroid-inducible expression of the 3,17beta-hydroxysteroid dehydrogenase gene in Comamonas testosteroni ATCC11996
Chem.-Biol. Interact.
202
116-125
2013
Comamonas testosteroni (P19871), Comamonas testosteroni ATCC 119960 (P19871)
Manually annotated by BRENDA team
Yepuru, M.; Wu, Z.; Kulkarni, A.; Yin, F.; Barrett, C.M.; Kim, J.; Steiner, M.S.; Miller, D.D.; Dalton, J.T.; Narayanan, R.
Steroidogenic enzyme AKR1C3 is a novel androgen receptor-selective coactivator that promotes prostate cancer growth
Clin. Cancer Res.
19
5613-5625
2013
Homo sapiens (P42330), Homo sapiens
Manually annotated by BRENDA team
Aceves-Ramos, A.; de la Torre, P.; Hinojosa, L.; Ponce, A.; García-Villegas, R.; Laclette, J.P.; Bobes, R.J.; Romano, M.C.
Cloning, characterization and functional expression of Taenia solium 17 beta-hydroxysteroid dehydrogenase
Gen. Comp. Endocrinol.
203
186-192
2014
Taenia solium
Manually annotated by BRENDA team
Endo, S.; Noda, M.; Ikari, A.; Tatematsu, K.; El-Kabbani, O.; Hara, A.; Kitade, Y.; Matsunaga, T.
Characterization of hamster NAD+-dependent 3(17)beta-hydroxysteroid dehydrogenase belonging to the aldo-keto reductase 1C subfamily
J. Biochem.
158
425-434
2015
Mesocricetus auratus (A0A097ZMZ1), Mesocricetus auratus
Manually annotated by BRENDA team
Roy, J.; Fournier, M.A.; Maltais, R.; Kenmogne, L.C.; Poirier, D.
In vitro and in vivo evaluation of a 3beta-androsterone derivative as inhibitor of 17beta-hydroxysteroid dehydrogenase type 3
J. Steroid Biochem. Mol. Biol.
141
44-51
2014
Rattus norvegicus
Manually annotated by BRENDA team
Roy, J.; Fournier, M.A.; Maltais, R.; Kenmogne, L.C.; Poirier, D.
Reprint of in vitro and in vivo evaluation of a 3beta-androsterone derivative as inhibitor of 17beta-hydroxysteroid dehydrogenase type 3
J. Steroid Biochem. Mol. Biol.
153
170-178
2015
Rattus norvegicus (O54939), Homo sapiens (P37058), Rattus norvegicus Sprague-Dawley (O54939)
Manually annotated by BRENDA team
Mansour, M.F.; Pelletier, M.; Boulet, M.-M.; Mayrand, D.; Brochu, G.; Lebel, S.; Poirier, D.; Fradette, J.; Cianflone, K.; Luu-The, V.; Tchernof, A.
Oxidative activity of 17beta-hydroxysteroid dehydrogenase on testosterone in male abdominal adipose tissues and cellular localization of 17beta-HSD type 2
Mol. Cell. Endocrinol.
414
168-176
2015
Homo sapiens
Manually annotated by BRENDA team
Li, T.; Stephen, P.; Zhu, D.W.; Shi, R.; Lin, S.X.
Crystal structures of human 17beta-hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP+ reveal the mechanism of substrate inhibition
FEBS J.
286
2155-2166
2019
Homo sapiens (P14061)
Manually annotated by BRENDA team
Suzuki, H.; Ozaki, Y.; Gen, K.; Kazeto, Y.
Japanese eel retinol dehydrogenases 11/12-like are 17-ketosteroid reductases involved in sex steroid synthesis
Gen. Comp. Endocrinol.
305
113685
2021
Anguilla japonica
Manually annotated by BRENDA team
Fernández-Cabezón, L.; Galán, B.; García, J.
Engineering Mycobacterium smegmatis for testosterone production
Microb. Biotechnol.
10
151-161
2017
Curvularia lunata, Comamonas testosteroni (P19871), Comamonas testosteroni ATCC 11996 (P19871)
Manually annotated by BRENDA team
Aka, J.; Calvo, E.; Lin, S.
Estradiol-independent modulation of breast cancer transcript profile by 17beta-hydroxysteroid dehydrogenase type 1
Mol. Cell. Endocrinol.
439
175-186
2017
Homo sapiens (P14061)
Manually annotated by BRENDA team
Salah, M.; Abdelsamie, A.S.; Frotscher, M.
Inhibitors of 17?-hydroxysteroid dehydrogenase type 1, 2 and 14 Structures, biological activities and future challenges
Mol. Cell. Endocrinol.
489
66-81
2019
Homo sapiens (P14061)
Manually annotated by BRENDA team
Hilborn, E.; Stal, O.; Jansson, A.
Estrogen and androgen-converting enzymes 17beta-hydroxysteroid dehydrogenase and their involvement in cancer with a special focus on 17beta-hydroxysteroid dehydrogenase type 1, 2, and breast cancer
Oncotarget
8
30552-30562
2017
Homo sapiens (P14061)
Manually annotated by BRENDA team
Hilborn, E.; Stal, O.; Alexeyenko, A.; Jansson, A.
The regulation of hydroxysteroid 17beta-dehydrogenase type 1 and 2 gene expression in breast cancer cell lines by estradiol, dihydrotestosterone, microRNAs, and genes related to breast cancer
Oncotarget
8
62183-62194
2017
Homo sapiens (P14061)
Manually annotated by BRENDA team
Emanuelsson, I.; Almokhtar, M.; Wikvall, K.; Groenbladh, A.; Nylander, E.; Svensson, A.L.; Fex Svenningsen, A.; Norlin, M.
Expression and regulation of CYP17A1 and 3?-hydroxysteroid dehydrogenase in cells of the nervous system Potential effects of vitamin D on brain steroidogenesis
Neurochem. Int.
113
46-55
2018
Rattus norvegicus
Manually annotated by BRENDA team