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1.1.1.82: malate dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about malate dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.1.1.82

Reaction

(S)-malate
+
NADP+
=
oxaloacetate
+
NADPH
+
H+

Synonyms

(S)-malate dehydrogenase, dehydrogenase, malate (nicotinamide adenine dinucleotide phosphate), L-malate:NAD oxidoreductase, malate NADP dehydrogenase, malic dehydrogenase (nicotinamide adenine dinucleotide phosphate), MDH, NADP malate dehydrogenase, NADP+-dependent malate dehydrogenase, NADP-dependent malate dehydrogenase, NADP-linked malate dehydrogenase, NADP-malate dehydrogenase, NADP-malic enzyme, NADP-MDH, NADP-MDH1, NADP-MDH2, NADPH-MDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.82 malate dehydrogenase (NADP+)

Activating Compound

Activating Compound on EC 1.1.1.82 - malate dehydrogenase (NADP+)

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
acetone
-
increases the activity of the oxidized truncated enzyme form, optimal concentration 15%
carboxypeptidase Y
-
incubation of the native oxidized enzyme at pH 6.0, 25°C, results in slow activation. A small carboxy-terminal peptide of the native enzyme is accessible to proteolytic degradation followed by activation of the inactive oxidized enzyme. This peptide is involved in the regulation of activity, tetramer formation and thioredoxin binding
-
dithiothreitol
DTT
activates enzyme in free extracts
guanidine
-
can activate oxidized enzyme
light
NADP-MDH is a strictly redox-regulated, light-activated enzyme that is inactive in the dark
-
methanol
-
increases the activity of the oxidized truncated enzyme form, optimal concentration 8%
reduced thioredoxin
-
thioredoxin
additional information
-