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0.00306
((4-methoxyphenyl)carbamoyl) (5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl)amide
pH 8.0, 25°C
-
0.00659
(2E)-1-[(2-fluorophenyl)(imino)methyl]-2-[(4-fluorophenyl)methylidene]-N-[(piperazin-1-yl)methyl]hydrazine-1-carbothioamide
pH and temperature not specified in the publication
-
0.00846
(2E)-1-[(2-fluorophenyl)(imino)methyl]-N-[(piperazin-1-yl)methyl]-2-[[4-(trifluoromethyl)phenyl]methylidene]hydrazine-1-carbothioamide
pH and temperature not specified in the publication
-
0.01975
(2E)-2-[(4-chlorophenyl)methylidene]-1-[(2-fluorophenyl)(imino)methyl]-N-[(piperazin-1-yl)methyl]hydrazine-1-carbothioamide
pH and temperature not specified in the publication
-
0.03519
(2E)-2-[(4-chlorophenyl)methylidene]-N-[[4-(4,6-dimethylpyrimidin-2-yl)piperazin-1-yl]methyl]-1-[imino(3,4,5-trimethoxy-2-nitrophenyl)methyl]hydrazine-1-carbothioamide
pH and temperature not specified in the publication
-
0.00038
(2E)-N-[[4-(4,6-dimethylpyrimidin-2-yl)piperazin-1-yl]methyl]-1-[(2-fluorophenyl)(imino)methyl]-2-[(4-fluorophenyl)methylidene]hydrazine-1-carbothioamide
pH and temperature not specified in the publication
-
0.00371
(E)-[6-(4-fluorophenyl)-2-sulfanylidene-1,6-dihydropyrimidin-5(2H)-ylidene](4-methylphenyl)methanolate
pH 8.0, 25°C
-
0.00002
1-aminocarbonyl-cyclopropane carboxylate
-
-
0.0203
1-aminocarbonylcyclopropanecarboxylate
pH 8.0, 30°C, recombinant enzyme
0.031
1-carbamoylcyclopropanecarboxylic acid
-
pH 8.0, 30°C
0.000058
1-cyano-cyclopropane carboxylate
-
-
0.0585
1-cyano-cyclopropane-1-carboxylate
pH and temperature not specified in the publication
-
207.9
1-cyano-N-[[(E)-(3,3-dichloroprop-1-yn-1-yl)diazenyl]sulfanyl]cyclopropanecarboxamide
-
-
0.0585
1-cyanocyclopropanecarboxylate
pH 8.0, 30°C, recombinant enzyme
0.095 - 95.3
1-cyanocyclopropanecarboxylic acid
0.0056
1-hydroxycyclopropanecarboxylate
pH 8.0, 30°C, recombinant enzyme
0.145
2,3-dihydroxy-3-isovalerate
-
pH 8.2, 30°C, (2S)-2-aceto-2-hydroxybutanoate as variable substrate, 0.250 mM NADPH as fixed substrate
0.095 - 1.5
2,3-dihydroxyisovalerate
0.00019 - 0.00046
2-dimethylphosphinoyl-2-hydroxyacetic acid
0.0003
2-dimethylphosphoryl-2-hydroxy-acetic acid
-
0.24 - 3.6
2-hydroxy-2-methyl-3-oxopentanoate
0.35
4,4'-(pentamethylenedioxy)dibenzamidne bis(2-hydroxyethanesulfonate)
-
-
0.00009 - 0.00303
cyclopropane-1,1-dicarboxylate
0.076
cyclopropane-1,1-dicarboxylic acid
-
pH 8.0, 30°C
0.000716
dimethylmalonate
pH 8.0, 30°C, recombinant enzyme
0.035
ethyl [(2-chlorophenyl)(hydroxy)amino](oxo)acetate
-
-
0.049
ethyl [hydroxy(2-methylphenyl)amino](oxo)acetate
-
-
0.351
ethyl [hydroxy(4-methylphenyl)amino](oxo)acetate
-
-
1.704
ethyl [[4-(cyanomethyl)phenyl](hydroxy)amino](oxo)acetate
-
-
0.0025 - 0.0032
ethylene glycol
0.034
methyl [hydroxy(1-methylethyl)amino](oxo)acetate
-
-
0.000153 - 0.000531
MMV553002
-
0.0000222 - 0.0000384
MMV688271
-
0.00472 - 0.00835
N-(4-chlorophenyl)-N'-[5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl]thiourea
-
0.00202 - 0.00548
N-(4-methoxyphenyl)-N'-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]thiourea
-
0.00927
N-(4-methoxyphenyl)-N'-[5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl]thiourea
pH 8.0, 25°C
-
0.000026 - 0.00275
N-Hydroxy-N-isopropyloxamate
0.0000079 - 0.0000903
N-isopropyloxalyl hydroxamate
-
0.00306
N-[(4-methoxyphenyl)carbamoyl]-5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-aminide
pH 8.0, 25°C
-
additional information
1-cyano-N-(4-methylphenyl)cyclopropanecarboxamide
0.095
1-cyanocyclopropanecarboxylic acid
-
pH 8.0, 30°C
95.3
1-cyanocyclopropanecarboxylic acid
-
-
0.095
2,3-dihydroxyisovalerate
-
pH 8.2, 30°C, (2S)-2-acetolactate as variable substrate, 0.250 mM NADPH as fixed substrate
0.935
2,3-dihydroxyisovalerate
-
pH 8.2, 30°C, NADPH as variable substrate, 0.2 mM (2S)-2-acetolactate as fixed substrate
1.5
2,3-dihydroxyisovalerate
-
pH 8.2, 30°C, NADPH as variable substrate, 0.2 mM (2S)-2-aceto-2-hydroxybutanoate as fixed substrate
0.00019
2-dimethylphosphinoyl-2-hydroxyacetic acid
-
pH 7.5, 25°C, with 2-aceto-2-hydroxybutyrate as substrate
0.00046
2-dimethylphosphinoyl-2-hydroxyacetic acid
-
pH 7.5, 25°C, with 2-acetolactate as substrate
0.0003
2-dimethylphosphoryl-2-hydroxy-acetic acid
-
pH 8.0, 25°C
-
0.0003
2-dimethylphosphoryl-2-hydroxy-acetic acid
pH 8.0, 25°C
-
0.24
2-hydroxy-2-methyl-3-oxopentanoate
-
pH 8.2, 30°C, (2S)-2-aceto-2-hydroxybutanoate as variable substrate, 0.075 mM NADPH as fixed substrate
0.245
2-hydroxy-2-methyl-3-oxopentanoate
-
pH 8.2, 30°C, (2S)-2-acetolactate as variable substrate, 0.075 mM NADPH as fixed substrate
1.7
2-hydroxy-2-methyl-3-oxopentanoate
-
pH 8.2, 30°C, NADPH as variable substrate, 0.2 mM (2S)-2-acetolactate as fixed substrate
3.6
2-hydroxy-2-methyl-3-oxopentanoate
-
pH 8.2, 30°C, NADPH as variable substrate, 0.2 mM (2S)-2-aceto-2-hydroxybutanoate as fixed substrate
0.00009
cyclopropane-1,1-dicarboxylate
-
-
0.0000903
cyclopropane-1,1-dicarboxylate
pH 8.0, 30°C, recombinant enzyme, versus hydroxypyruvate
0.00273
cyclopropane-1,1-dicarboxylate
pH 8.0, 25°C
0.00275
cyclopropane-1,1-dicarboxylate
pH and temperature not specified in the publication
0.00277
cyclopropane-1,1-dicarboxylate
pH 8.0, 25°C
0.00303
cyclopropane-1,1-dicarboxylate
-
pH 8.0, 25°C
0.00303
cyclopropane-1,1-dicarboxylate
pH 8.0, 25°C
0.0025
ethylene glycol
pH 8.0, 30°C, recombinant enzyme, competitive mode
0.0032
ethylene glycol
pH 8.0, 30°C, recombinant enzyme, uncompetitive mode
0.000153
MMV553002
pH 8.0, temperature not specified in the publication
-
0.000531
MMV553002
pH 8.0, temperature not specified in the publication
-
0.0000222
MMV688271
pH 8.0, temperature not specified in the publication
-
0.0000384
MMV688271
pH 8.0, temperature not specified in the publication
-
0.00472
N-(4-chlorophenyl)-N'-[5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl]thiourea
pH 8.0, 25°C
-
0.00835
N-(4-chlorophenyl)-N'-[5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl]thiourea
pH 8.0, 25°C
-
0.00202
N-(4-methoxyphenyl)-N'-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]thiourea
pH 8.0, 25°C
-
0.00548
N-(4-methoxyphenyl)-N'-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]thiourea
pH 8.0, 25°C
-
0.000026
N-Hydroxy-N-isopropyloxamate
-
pH 8.0, 25°C
0.000026
N-Hydroxy-N-isopropyloxamate
pH 8.0, 25°C
0.0000974
N-Hydroxy-N-isopropyloxamate
at pH 8.5 and 37°C
0.0027
N-Hydroxy-N-isopropyloxamate
-
pH 8.0, 30°C
0.00275
N-Hydroxy-N-isopropyloxamate
-
-
0.0000079
N-isopropyloxalyl hydroxamate
pH 8.0, 25°C
-
0.0000079
N-isopropyloxalyl hydroxamate
pH 8.0, 25°C, intact N-isopropyloxalyl hydroxamate is present in only 25% of binding sites, whereas its deoxygenated form is present in the remaining sites. This deoxy form of N-isopropyloxalyl hydroxamate binds rapidly to the enzyme, but with much weaker affinity (Ki: 0.021 mM)
-
0.0000903
N-isopropyloxalyl hydroxamate
pH and temperature not specified in the publication
-
0.005
NADP+
-
pH 8.2, 30°C, NADPH as variable substrate, 0.2 mM (2S)-2-acetolactate as fixed substrate
0.0075
NADP+
-
pH 8.2, 30°C, NADPH as variable substrate, 0.2 mM (2S)-2-aceto-2-hydroxybutanoate as fixed substrate
0.225
NADP+
-
pH 8.2, 30°C, (2S)-2-aceto-2-hydroxybutanoate as variable substrate, 0.075 mM NADPH as fixed substrate
0.33
NADP+
-
pH 8.2, 30°C, (2S)-2-acetolactate as variable substrate, 0.075 mM NADPH as fixed substrate
0.0012
NADPH
-
pH 8.0, 22°C, wild-type enzyme
0.0018
NADPH
-
pH 8.0, 22°C, mutant enzyme K69L
0.0039
NADPH
-
pH 8.0, 22°C, mutant enzyme K75Q
0.0085
NADPH
-
pH 8.0, 22°C, mutant enzyme R68Q
0.0226
NADPH
-
pH 8.0, 22°C, mutant enzyme K76Q
additional information
1-cyano-N-(4-methylphenyl)cyclopropanecarboxamide
-
value above 300
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
inhibition mechanism and kinetics
-