1.1.1.87: homoisocitrate dehydrogenase

This is an abbreviated version!
For detailed information about homoisocitrate dehydrogenase, go to the full flat file.

Reaction

Synonyms

(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating), 2-hydroxy-3-carboxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating), beta-decarboxylating dehydrogenase, dehydrogenase, homoisocitrate, EC 1.1.1.155, HIc, HIc dehydrogenase, HICDH, homoisocitrate dehydrogenase, homoisocitric dehydrogenase, isocitrate-homoisocitrate dehydrogenase, LYS12, protein PH1722, ScHICDH, TK0280

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.87 homoisocitrate dehydrogenase

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Results	in table
2	Activating Compound
335	AA Sequence
5	Application
2	CAS Registry Number
9	Cloned(Commentary)
21	Cofactor
3	Crystallization (Commentary)
8	General Information
2	General Stability
3	IC50 Value
32	Inhibitors
40	kcat/KM [mM/s]
15	Ki Value [mM]
93	KM Value [mM]
30	Metals/Ions
8	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
58	Organism
9	Pathway
14	PDB ID
17	pH Optimum
6	pH Range
1	pH Stability
23	Protein Variants
11	Purification (Commentary)
3	Reaction
4	Reaction Type
30	Reference
9	Source Tissue
13	Specific Activity [micromol/min/mg]
4	Storage Stability
93	Substrates and Products (Substrate)
10	Subunits
41	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
2	Temperature Stability [°C]
63	Turnover Number [1/s]

Source Tissue

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Source Tissue on EC 1.1.1.87 - homoisocitrate dehydrogenase

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SOURCE TISSUE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

SOURCE

brain

Mus musculus

-

mRNA level of isoform Rdh10 declines during development, with strong and lasting expression in the meninges and choroid plexuses. Expression is also present in the striatum

687988

brenda

choroid plexus

Mus musculus

-

mRNA level of isoform Rdh10 declines during development, with strong and lasting expression in the meninges and choroid plexuses. Expression is also present in the striatum

687988

brenda

corpus striatum

Mus musculus

-

mRNA level of isoform Rdh10 declines during development, with strong and lasting expression in the meninges and choroid plexuses. Expression is also present in the striatum

687988

brenda

ear

Mus musculus

-

inner ear, specific expression of isoform Rdh10 in the endolymphatic system and stria vascularis

687988

brenda

eye

Mus musculus

-

mRNA expression of isoform Rdh10 both in the prospective pigmented epithelium and neural retina

687988

brenda

meninx

Mus musculus

-

mRNA level of isoform Rdh10 declines during development, with strong and lasting expression in the meninges and choroid plexuses. Expression is also present in the striatum

687988

brenda

olfactory tract

Mus musculus

-

and vibrissae follicles, expression of isoform Rdh10 from early stages in regions where sensory receptors appear and mesenchymal/epithelial interactions take place

687988

brenda

retina

Mus musculus

-

mRNA expression of isoform Rdh10 both in the prospective pigmented epithelium and neural retina

687988

brenda

retinal pigment epithelium

Mus musculus

-

mRNA expression of isoform Rdh10 both in the prospective pigmented epithelium and neural retina

687988

brenda