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1.1.1.87: homoisocitrate dehydrogenase

This is an abbreviated version!
For detailed information about homoisocitrate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.87

Reaction

(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
+
NAD+
=
2-oxoadipate
+
CO2
+
NADH
+
H+

Synonyms

(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating), 2-hydroxy-3-carboxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating), beta-decarboxylating dehydrogenase, dehydrogenase, homoisocitrate, EC 1.1.1.155, HIc, HIc dehydrogenase, HICDH, homoisocitrate dehydrogenase, homoisocitric dehydrogenase, isocitrate-homoisocitrate dehydrogenase, LYS12, protein PH1722, ScHICDH, TK0280

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.87 homoisocitrate dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.87 - homoisocitrate dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+
2-oxoadipate + CO2 + NADH + H+
show the reaction diagram
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+
2-oxoadipate + NADH + H+ + CO2
show the reaction diagram
(2R,3S)-3-(2-hydroxyethyl)malate + NAD+
?
show the reaction diagram
(2R,3S)-3-(3-aminopropyl)malate + NAD+
?
show the reaction diagram
(2R,3S)-3-(3-hydroxypropyl)malate + NAD+
?
show the reaction diagram
(2R,3S)-3-(4-hydroxybutyl)malate + NAD+
?
show the reaction diagram
(2R,3S)-3-(4-pentenyl)malic acid + NAD+
?
show the reaction diagram
(2R,3S)-3-allylmalic acid + NAD+
?
show the reaction diagram
(2R,3S)-3-propylmalic acid + NAD+
?
show the reaction diagram
1-hydroxy-1,2,3-propanetricarboxylate + NAD+
?
show the reaction diagram
1-hydroxy-1,2,4-butanetricarboxylate + NAD+
2-oxoadipate + CO2 + NADH
show the reaction diagram
2(R),3(S)-homoisocitrate + NAD+
alpha-ketoadipate + NADH + CO2 + H+
show the reaction diagram
-
with homoisocitrate as the substrate, no primary deuterium isotope effect is observed, and a small 13C kinetic isotope effect indicates that the decarboxylation step contributes only slightly to rate limitation
-
-
?
3-carboxy-2-hydroxyadipate + NAD+
2-oxoadipate + CO2 + NADH
show the reaction diagram
3-isopropylmalate + NAD+
?
show the reaction diagram
3-isopropylmalate + NAD+
alpha-ketoisocaproate + NADH + H+ + CO2
show the reaction diagram
3-vinylmalate + NAD+
?
show the reaction diagram
D-malate + NAD+
?
show the reaction diagram
ethylmalate + NAD+
?
show the reaction diagram
homoisocitrate + NAD+
2-oxoadipate + CO2 + NADH + H+
show the reaction diagram
homoisocitrate + NAD+
?
show the reaction diagram
homoisocitrate + NAD+
alpha-ketoadipate + NADH + CO2
show the reaction diagram
-
-
-
-
r
homoisocitrate + NAD+
alpha-ketoadipate + NADH + CO2 + H+
show the reaction diagram
-
-
-
-
r
homoisocitrate + NAD+
alpha-ketoadipate + NADH + H+ + CO2
show the reaction diagram
homoisocitrate + NADP+
alpha-ketoadipate + NADPH + H+ + CO2
show the reaction diagram
-
-
-
-
r
isocitrate + NAD+
?
show the reaction diagram
isocitrate + NAD+
? + NADH + H+
show the reaction diagram
-
low activity
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
show the reaction diagram
isopropylmalate + NAD+
?
show the reaction diagram
-
-
-
-
?
threo-D-isocitric acid + NAD+
?
show the reaction diagram
-
with isocitrate as the substrate, primary deuterium and 13C isotope effects indicate that hydride transfer and decarboxylation steps contribute to rate limitation, and that the decarboxylation step is the more rate-limiting of the two. The multiple-substrate deuterium/13C isotope effects suggest a stepwise mechanism with hydride transfer preceding decarboxylation
-
-
?
trisodium (2S,3R)-2-(carboxylatomethoxy)-3-hydroxybutanedioate + NAD+
? + NADH + CO2
show the reaction diagram
-
-
-
-
?
trisodium (2S,3R)-2-[(carboxylatomethyl)amino]-3-hydroxybutanedioate + NAD+
? + NADH + CO2
show the reaction diagram
-
-
-
-
?
additional information
?
-