1.1.1.B4: (R)-specific secondary alcohol dehydrogenase (NADH)
This is an abbreviated version!
For detailed information about (R)-specific secondary alcohol dehydrogenase (NADH), go to the full flat file.
Reaction
Synonyms
(R)-1-phenylethanolsynthase, (R)-epinephrine dehydrogenase, ADH, ADH1, ADH2, ADHTt, carbonyl reductase, carbonyl reductase (NADH, specific for (S)-configuration of alcohol), CHY1186, CpCR, mLDH, More, RPES, SADH, SDR, secondary alcohol dehydrogenase, short chain dehydrogenase, short-chain NAD(H)-dependent alcohol dehydrogenase
ECTree
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Cofactor
Cofactor on EC 1.1.1.B4 - (R)-specific secondary alcohol dehydrogenase (NADH)
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NAD+
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critical role of the D37 residue in discriminating NAD(H) from NADP(H)
NADH
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critical role of the D37 residue in discriminating NAD(H) from NADP(H)
NADPH
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clear preference for NADPH as cofactor. The phosphate group of NADPH interacts with both the side chains and main-chain amides of Arg38 and Thr15, stabilizing this cofactor significantly better than NADH
additional information
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the enzyme shows no activity for NADPH or NADP+
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