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1.1.1.B4: (R)-specific secondary alcohol dehydrogenase (NADH)

This is an abbreviated version!
For detailed information about (R)-specific secondary alcohol dehydrogenase (NADH), go to the full flat file.

Word Map on EC 1.1.1.B4

Reaction

(R)-R-CHOH-R'
+
NAD+
=
R-CO-R'
+
NADH
+
H+

Synonyms

(R)-1-phenylethanolsynthase, (R)-epinephrine dehydrogenase, ADH, ADH1, ADH2, ADHTt, carbonyl reductase, carbonyl reductase (NADH, specific for (S)-configuration of alcohol), CHY1186, CpCR, mLDH, More, RPES, SADH, SDR, secondary alcohol dehydrogenase, short chain dehydrogenase, short-chain NAD(H)-dependent alcohol dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B4 (R)-specific secondary alcohol dehydrogenase (NADH)

Temperature Stability

Temperature Stability on EC 1.1.1.B4 - (R)-specific secondary alcohol dehydrogenase (NADH)

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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
20 - 40
-
purified enzyme, stable at
30
-
wild-type, half-life 160 h, mutant R38P, half-life 220 h
42
-
wild-type, half-life 1.25 h, mutant R38P, half-life 3 h
50
-
24 h, purified recombinant enzyme, 142% inactivation
55
-
purified enzyme, retains almost 40% of maximal activity for 60 min
90
-
30 min, purified recombinant enzyme, 50% inactivation