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1.1.3.7: aryl-alcohol oxidase

This is an abbreviated version!
For detailed information about aryl-alcohol oxidase, go to the full flat file.

Word Map on EC 1.1.3.7

Reaction

an aromatic primary alcohol
+
O2
=
an aromatic aldehyde
+
H2O2

Synonyms

AAO, AAO2, AAOx, alcohol: O2 oxidoreductase, AOX, arom. alcohol oxidase, aryl alcohol oxidase, arylalcohol oxidase, CpSAO, CtSAO, GaoB, GLRG_02805, GMC oxidoreductase-like protein, HMFO, More, MtGloA, MYCTH_2299749, oxidase, aryl alcohol, salicyl alcohol oxidase, um04044, VAO, veratryl alcohol oxidase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.3 With oxygen as acceptor
                1.1.3.7 aryl-alcohol oxidase

Reference

Reference on EC 1.1.3.7 - aryl-alcohol oxidase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Muheim, A.; Leisola, M.S.A.; Schoemaker, H.E.
Aryl-alcohol oxidase and lignin peroxidase from the white-rot fungus Bjerkandera adusta
J. Biotechnol.
13
159-167
1990
Bjerkandera adusta, no activity in Phanerochaete chrysosporium
-
Manually annotated by BRENDA team
Guillen, F.; Martinez, A.T.; Martinez, M.J.
Production of hydrogen peroxide by aryl-alcohol oxidase from the ligninolytic fungus Pleurotus eryhgii
Appl. Microbiol. Biotechnol.
32
465-469
1990
Pleurotus eryngii
-
Manually annotated by BRENDA team
Muheim, A.; Waldner, R.; Leisola, M.S.A.; Fiechter, A.
An extracellular aryl-alcohol oxidase from the white-rot fungus Bjerkandera adusta
Enzyme Microb. Technol.
12
204-209
1990
Bjerkandera adusta
-
Manually annotated by BRENDA team
Waldner, R.; Leisola, M.S.A.; Fiechter, A.
Comparison of ligninolytic activities of selected white-rot fungi
Appl. Microbiol. Biotechnol.
29
400-407
1988
Bjerkandera adusta, Phanerodontia chrysosporium, Trametes versicolor, Rigidoporus microporus, Pleurotus ostreatus
-
Manually annotated by BRENDA team
Bourbonnais, R.; Paice, M.G.
Veratryl alcohol oxidases from the lignin-degrading basidiomycete Pleurotus sajor-caju
Biochem. J.
255
445-450
1988
Lentinus sajor-caju
Manually annotated by BRENDA team
Farmer, V.C.; Henderson, M.E.K.; Russell, J.D.
Aromatic-alcohol-oxidase activity in the growth medium of Polystictus versicolor
Biochem. J.
74
257-262
1960
Trametes versicolor
Manually annotated by BRENDA team
Mann, V.; Large, A.; Khan, S.; Malik, Z.; Connock, M.J.
Aromatic alcohol oxidase: a new membrane-bound H2O2-generating enzyme in alimentary tiddues of the slug Arion ater
J. Exp. Zool.
251
265-274
1989
Arion ater
-
Manually annotated by BRENDA team
Marzullo, L.; Cannio, R.; Giardina, P.; Santini, M.T.; Sannia, G.
Veratryl alcohol oxidase from Pleurotus ostreatus participates in lignin biodegradation and prevents polymerization of laccase-oxidized substrates
J. Biol. Chem.
270
3823-3827
1995
Pleurotus ostreatus
Manually annotated by BRENDA team
Varela, E.; Martinez, A.T.; Martinez, M.J.
Molecular cloning of aryl-alcohol oxidase from the fungus Pleurotus eryngii, an enzyme involved in lignin degradation
Biochem. J.
341
113-117
1999
Pleurotus eryngii
-
Manually annotated by BRENDA team
Varela, E.; Guillen, F.; Martinez, A.T.; Martinez, M.J.
Expression of Pleurotus eryngii aryl-alcohol oxidase in Aspergillus nidulans: purification and characterization of the recombinant enzyme
Biochim. Biophys. Acta
1546
107-113
2001
Pleurotus eryngii
Manually annotated by BRENDA team
Varela, E.; Bockle, B.; Romero, A.; Martinez, A.T.; Martinez, M.J.
Biochemical characterization, cDNA cloning and protein crystallization of aryl-alcohol oxidase from Pleurotus pulmonarius
Biochim. Biophys. Acta
1476
129-138
2000
Pleurotus pulmonarius
Manually annotated by BRENDA team
Asada, Y.; Watanabe, A.; Ohtsu, Y.; Kuwahara, M.
Purification and characterization of an aryl-alcohol oxidase from the lignin-degrading basidiomycete Phanerochaete chrysosporium
Biosci. Biotechnol. Biochem.
59
1339-1341
1995
Phanerodontia chrysosporium
-
Manually annotated by BRENDA team
Guillen, F.; Martinez, A.T.; Martinez, M.J.
Substrate specificity and properties of the aryl-alcohol oxidase from ligninolytic fungus Pleurotus eryngii
Eur. J. Biochem.
209
603-611
1992
Pleurotus eryngii
Manually annotated by BRENDA team
Brückmann, M.; Termonia, A.; Pasteels, J.M.; Hartmann, T.
Characterization of an extracellular salicyl alcohol oxidase from larval defensive secretions of Chrysomela populi and Phratora vitellinae (Chrysomelina)
Insect Biochem. Mol. Biol.
32
1517-1523
2002
Chrysomela populi, Phratora vitellinae
Manually annotated by BRENDA team
Okamoto, K.; Yanase, H.
Aryl alcohol oxidases from the white-rot basidiomycete Pleurotus ostreatus
Mycoscience
43
391-395
2002
Pleurotus ostreatus
-
Manually annotated by BRENDA team
Kumar, A.K.; Goswami, P.
Functional characterization of alcohol oxidases from Aspergillus terreus MTCC 6324
Appl. Microbiol. Biotechnol.
72
906-911
2006
Aspergillus terreus, Aspergillus terreus MTCC 6324
Manually annotated by BRENDA team
Ferreira, P.; Medina, M.; Guillen, F.; Martinez, M.J.; Van Berkel, W.J.; Martinez, A.T.
Spectral and catalytic properties of aryl-alcohol oxidase, a fungal flavoenzyme acting on polyunsaturated alcohols
Biochem. J.
389
731-738
2005
Pleurotus eryngii
Manually annotated by BRENDA team
Sampedro, I.; DAnnibale, A.; Ocampo, J.A.; Stazi, S.R.; Garcia-Romera, I.
Solid-state cultures of Fusarium oxysporum transform aromatic components of olive-mill dry residue and reduce its phytotoxicity
Biores. Technol.
98
3547-3554
2007
no activity in Fusarium oxysporum, no activity in Fusarium oxysporum BAFC 738
Manually annotated by BRENDA team
D'Annibale, A.; Ricci, M.; Leonardi, V.; Quaratino, D.; Mincione, E.; Petruccioli, M.
Degradation of aromatic hydrocarbons by white-rot fungi in a historically contaminated soil
Biotechnol. Bioeng.
90
723-731
2005
no activity in Phanerochaete chrysosporium, Pleurotus pulmonarius, no activity in Phanerochaete chrysosporium NRRL 6361
Manually annotated by BRENDA team
Kabe, Y.; Osawa, T.; Ishihara, A.; Kabe, T.
Decolorization of coal humic acid by extracellular enzymes produced by white-rot fungi
Coal Prep.
25
211-220
2005
Pleurotus pulmonarius
-
Manually annotated by BRENDA team
Ferreira, P.; Ruiz-Duenas, F.J.; Martinez, M.J.; van Berkel, W.J.; Martinez, A.T.
Site-directed mutagenesis of selected residues at the active site of aryl-alcohol oxidase, an H2O2-producing ligninolytic enzyme
FEBS J.
273
4878-4888
2006
Pleurotus eryngii
Manually annotated by BRENDA team
Saparrata, M.C.; Guillen, F.
Ligninolytic ability and potential biotechnology applications of the south american fungus Pleurotus laciniatocrenatus
Folia Microbiol. (Praha)
50
155-160
2005
Pleurotus laciniatocrenatus
Manually annotated by BRENDA team
Madhurendr, M.; Prasad, N.
Veratryl alcohol oxidase and laccase activity in Pleurotus spp
J. Plant Biol.
32
129-132
2005
Pleurotus ostreatus, Lentinus sajor-caju
-
Manually annotated by BRENDA team
Ruiz-Duenas, F.J.; Ferreira, P.; Martinez, M.J.; Martinez, A.T.
In vitro activation, purification, and characterization of Escherichia coli expressed aryl-alcohol oxidase, a unique H2O2-producing enzyme
Protein Expr. Purif.
45
191-199
2006
Pleurotus eryngii (O94219), Pleurotus eryngii
Manually annotated by BRENDA team
Michalski, C.; Mohagheghi, H.; Nimtz, M.; Pasteels, J.; Ober, D.
Salicyl alcohol oxidase of the chemical defense secretion of two chrysomelid leaf beetles: Molecular and functional characterization of two new members of the GMC oxidoreductase gene family
J. Biol. Chem.
283
19219-19228
2008
Chrysomela tremula (B4F334), Chrysomela tremula, Chrysomela populi (B4F335), Chrysomela populi
Manually annotated by BRENDA team
Ferreira, P.; Hernandez-Ortega, A.; Herguedas, B.; Martinez, A.T.; Medina, M.
Aryl-alcohol oxidase involved in lignin degradation: a mechanistic study based on steady and pre-steady state kinetics and primary and solvent isotope effects with two alcohol substrates
J. Biol. Chem.
284
24840-24847
2009
Pleurotus eryngii (O94219)
Manually annotated by BRENDA team
Munteanu, F.; Ferreira, P.; Ruiz-Duenas, F.; Martinez, A.; Cavaco-Paulo, A.
ioelectrochemical investigations of aryl-alcohol oxidase from Pleurotus eryngii
J. Electroanal. Chem.
618
83-86
2008
Pleurotus eryngii
-
Manually annotated by BRENDA team
Fernandez, I.S.; Ruiz-Duenas, F.J.; Santillana, E.; Ferreira, P.; Martinez, M.J.; Martinez, A.T.; Romero, A.
Novel structural features in the GMC family of oxidoreductases revealed by the crystal structure of fungal aryl-alcohol oxidase
Acta Crystallogr. Sect. D
65
1196-1205
2009
Pleurotus eryngii (O94219), Pleurotus eryngii
Manually annotated by BRENDA team
Kumar, V.V.; Rapheal, V.S.
Induction and purification by three-phase partitioning of aryl alcohol oxidase (AAO) from Pleurotus ostreatus
Appl. Biochem. Biotechnol.
163
423-432
2011
Pleurotus ostreatus
Manually annotated by BRENDA team
Ferreira, P.; Hernandez-Ortega, A.; Herguedas, B.; Rencoret, J.; Gutierrez, A.; Martinez, M.J.; Jimenez-Barbero, J.; Medina, M.; Martinez, A.T.
Kinetic and chemical characterization of aldehyde oxidation by fungal aryl-alcohol oxidase
Biochem. J.
425
585-593
2010
Pleurotus eryngii (O94219)
Manually annotated by BRENDA team
Lupo, S.; Perez, A.; Martinez, S.; Simeto, S.; Rivas, F.; Bettucci, L.
In vitro characterization of Inocutis jamaicensis and experimental inoculation of Eucalyptus globulus standing trees
Forest Pathol.
39
293-303
2009
no activity in Inocutis jamaicensis
Manually annotated by BRENDA team
Hernandez-Ortega, A.; Ferreira, P.; Martinez, A.T.
Fungal aryl-alcohol oxidase: a peroxide-producing flavoenzyme involved in lignin degradation
Appl. Microbiol. Biotechnol.
93
1395-1410
2012
Bjerkandera adusta, Botrytis cinerea, Phanerodontia chrysosporium, Trametes versicolor, Rigidoporus microporus, Fusarium solani, Postia placenta, Pleurotus eryngii (O94219), Pleurotus eryngii
Manually annotated by BRENDA team
Hernandez-Ortega, A.; Borrelli, K.; Ferreira, P.; Medina, M.; Martinez, A.T.; Guallar, V.
Substrate diffusion and oxidation in GMC oxidoreductases: an experimental and computational study on fungal aryl-alcohol oxidase
Biochem. J.
436
341-350
2011
Pleurotus eryngii (O94219)
Manually annotated by BRENDA team
Hernandez-Ortega, A.; Lucas, F.; Ferreira, P.; Medina, M.; Guallar, V.; Martinez, A.T.
Role of active site histidines in the two half-reactions of the aryl-alcohol oxidase catalytic cycle
Biochemistry
51
6595-6608
2012
Pleurotus eryngii (O94219)
Manually annotated by BRENDA team
Tamboli, D.; Telke, A.; Dawkar, V.; Jadhav, S.; Govindwar, S.
Purification and characterization of bacterial aryl alcohol oxidase from Sphingobacterium sp. ATM and its uses in textile dye decolorization
Biotechnol. Bioprocess Eng.
16
661-668
2011
Sphingobacterium sp., Sphingobacterium sp. ATM
-
Manually annotated by BRENDA team
Hernandez-Ortega, A.; Ferreira, P.; Merino, P.; Medina, M.; Guallar, V.; Martinez, A.T.
Stereoselective hydride transfer by aryl-alcohol oxidase, a member of the GMC superfamily
ChemBioChem
13
427-435
2012
Pleurotus eryngii (O94219)
Manually annotated by BRENDA team
Hernandez-Ortega, A.; Lucas, F.; Ferreira, P.; Medina, M.; Guallar, V.; Martinez, A.T.
Modulating O2 reactivity in a fungal flavoenzyme: involvement of aryl-alcohol oxidase Phe-501 contiguous to catalytic histidine
J. Biol. Chem.
286
41105-41114
2011
Pleurotus eryngii (O94219)
Manually annotated by BRENDA team
Chakraborty, M.; Goel, M.; Chinnadayyala, S.R.; Dahiya, U.R.; Ghosh, S.S.; Goswami, P.
Molecular characterization and expression of a novel alcohol oxidase from Aspergillus terreus MTCC6324
PLoS ONE
9
e95368
2014
Aspergillus terreus (I7FDJ2), Aspergillus terreus MTCC6324 (I7FDJ2)
Manually annotated by BRENDA team
Vina-Gonzalez, J.; Gonzalez-Perez, D.; Ferreira, P.; Martinez, A.T.; Alcalde, M.
Focused directed evolution of aryl-alcohol oxidase in Saccharomyces cerevisiae by using chimeric signal peptides
Appl. Environ. Microbiol.
81
6451-6462
2015
Pleurotus eryngii
Manually annotated by BRENDA team
Couturier, M.; Mathieu, Y.; Li, A.; Navarro, D.; Drula, E.; Haon, M.; Grisel, S.; Ludwig, R.; Berrin, J.G.
Characterization of a new aryl-alcohol oxidase secreted by the phytopathogenic fungus Ustilago maydis
Appl. Microbiol. Biotechnol.
100
697-706
2016
Ustilago maydis
Manually annotated by BRENDA team
Galperin, I.; Javeed, A.; Luig, H.; Lochnit, G.; Ruehl, M.
An aryl-alcohol oxidase of Pleurotus sapidus heterologous expression, characterization, and application in a 2-enzyme system
Appl. Microbiol. Biotechnol.
100
8021-8030
2016
Pleurotus sapidus (A0A145Y386), Pleurotus sapidus, Pleurotus sapidus DSM 8266 (A0A145Y386)
Manually annotated by BRENDA team
Feldman, D.; Kowbel, D.J.; Glass, N.L.; Yarden, O.; Hadar, Y.
Detoxification of 5-hydroxymethylfurfural by the Pleurotus ostreatus lignolytic enzymes aryl alcohol oxidase and dehydrogenase
Biotechnol. Biofuels
8
63
2015
Pleurotus ostreatus (E5CZV8), Pleurotus ostreatus
Manually annotated by BRENDA team
Ferreira, P.; Hernandez-Ortega, A.; Lucas, F.; Carro, J.; Herguedas, B.; Borrelli, K.W.; Guallar, V.; Martinez, A.T.; Medina, M.
Aromatic stacking interactions govern catalysis in aryl-alcohol oxidase
FEBS J.
282
3091-3106
2015
Pleurotus eryngii (O94219)
Manually annotated by BRENDA team
Pardo-Planas, O.; Prade, R.A.; Wilkins, M.R.
High-yield production of aryl alcohol oxidase under limited growth conditions in small-scale systems using a mutant Aspergillus nidulans strain
J. Ind. Microbiol. Biotechnol.
44
247-257
2017
Thermothelomyces thermophilus
Manually annotated by BRENDA team
Gomez De Santos, P.; Lazaro, S.; Vin-Gonzalez, J.; Hoang, M.; Sanchez-Moreno, I.; Glieder, A.; Hollmann, F.; Alcalde, M.
Evolved peroxygenase-aryl alcohol oxidase fusions for self-sufficient oxyfunctionalization reactions
ACS Catal.
10
13524-13534
2020
Komagataella pastoris
-
Manually annotated by BRENDA team
Mathieu, Y.; Offen, W.; Forget, S.; Ciano, L.; Viborg, A.; Blagova, E.; Henrissat, B.; Walton, P.; Davies, G.; Brumer, H.
Discovery of a fungal copper radical oxidase with high catalytic efficiency toward 5-hydroxymethylfurfural and benzyl alcohols for bioprocessing
ACS Catal.
10
3042-3058
2020
Colletotrichum graminicola (E3Q9X3), Colletotrichum graminicola M1.001 (E3Q9X3)
-
Manually annotated by BRENDA team
Vina-Gonzalez, J.; Jimenez-Lalana, D.; Sancho, F.; Serrano, A.; Martinez, A.; Guallar, V.; Alcalde, M.
Structure-guided evolution of aryl alcohol oxidase from Pleurotus eryngii for the selective oxidation of secondary benzyl alcohols
Adv. Synth. Catal.
361
2514-2525
2019
Pleurotus eryngii (O94219)
-
Manually annotated by BRENDA team
de Almeida, T.; van Schie, M.; Ma, A.; Tieves, F.; Younes, S.; Fernandez-Fueyo, E.; Arends, I.; Riul, A.J.; Hollmann, F.
Efficient aerobic oxidation of trans-2-hexen-1-ol using the aryl alcohol oxidase from Pleurotus eryngii
Adv. Synth. Catal.
361
2668-2672
2019
Pleurotus eryngii (O94219)
-
Manually annotated by BRENDA team
Gandomkar, S.; Jost, E.; Loidolt, D.; Swoboda, A.; Pickl, M.; Elaily, W.; Daniel, B.; Fraaije, M.; Macheroux, P.; Kroutil, W.
Biocatalytic enantioselective oxidation of sec-allylic alcohols with flavin-dependent oxidases
Adv. Synth. Catal.
361
5264-5271
2019
Methylovorus sp. MP688 (E4QP00)
Manually annotated by BRENDA team
Vinambres, M.; Espada, M.; Martinez, A.T.; Serrano, A.
Screening and evaluation of new hydroxymethylfurfural oxidases for furandicarboxylic acid production
Appl. Environ. Microbiol.
86
e00842
2020
Pseudomonas nitroreducens, Pseudomonas sp. 11/12A, Methylovorus sp. MP688 (E4QP00)
Manually annotated by BRENDA team
Jankowski, N.; Koschorreck, K.; Urlacher, V.B.
High-level expression of aryl-alcohol oxidase 2 from Pleurotus eryngii in Pichia pastoris for production of fragrances and bioactive precursors
Appl. Microbiol. Biotechnol.
104
9205-9218
2020
Pleurotus eryngii (D3YBH4), Pleurotus eryngii
Manually annotated by BRENDA team
Varela, E.; Guillen, F.; Martinez, A.T.; Martinet, M.J.
Expression of Pleurotus eryngii aryl-alcohol oxidase in Aspergillus nidulans purification and characterization of the recombinant enzyme
Biochim. Biophys. Acta
1546
107-113
2001
Pleurotus eryngii (O94219), Pleurotus eryngii
Manually annotated by BRENDA team
Kadowaki, M.; Higasi, P.; de Godoy, M.; de Araujo, E.; Godoy, A.; Prade, R.; Polikarpov, I.
Enzymatic versatility and thermostability of a new aryl-alcohol oxidase from Thermothelomyces thermophilus M77
Biochim. Biophys. Acta
1864
129681
2020
Thermothelomyces thermophilus (G2PZJ2), Thermothelomyces thermophilus, Thermothelomyces thermophilus DSM 1799 (G2PZJ2)
Manually annotated by BRENDA team
Vina-Gonzalez, J.; Martinez, A.T.; Guallar, V.; Alcalde, M.
Sequential oxidation of 5-hydroxymethylfurfural to furan-2,5-dicarboxylic acid by an evolved aryl-alcohol oxidase
Biochim. Biophys. Acta
1868
140293
2020
Pleurotus eryngii (O94219)
Manually annotated by BRENDA team
Liu, E.; Li, M.; Abdella, A.; Wilkins, M.
Development of a cost-effective medium for submerged production of fungal aryl alcohol oxidase using a genetically modified Aspergillus nidulans strain
Biores. Technol.
305
123038
2020
Thermothelomyces thermophilus (G2PZJ2), Thermothelomyces thermophilus DSM 1799 (G2PZJ2)
Manually annotated by BRENDA team
Liu, E.; Wilkins, M.
Process optimization and scale-up production of fungal aryl alcohol oxidase from genetically modified Aspergillus nidulans in stirred-tank bioreactor
Biores. Technol.
315
123792
2020
Thermothelomyces thermophilus (G2PZJ2), Thermothelomyces thermophilus DSM 1799 (G2PZJ2)
Manually annotated by BRENDA team
Vina-Gonzalez, J.; Elbl, K.; Ponte, X.; Valero, F.; Alcalde, M.
Functional expression of aryl-alcohol oxidase in Saccharomyces cerevisiae and Pichia pastoris by directed evolution
Biotechnol. Bioeng.
115
1666-1674
2018
Pleurotus eryngii (O94219)
Manually annotated by BRENDA team
Serrano, A.; Calvino, E.; Carro, J.; Sanchez-Ruiz, M.I.; Canada, F.J.; Martinez, A.T.
Complete oxidation of hydroxymethylfurfural to furandicarboxylic acid by aryl-alcohol oxidase
Biotechnol. Biofuels
12
217
2019
Pleurotus eryngii (O94219), Pleurotus eryngii
Manually annotated by BRENDA team
Cleveland, M.; Lafond, M.; Xia, F.; Chung, R.; Mulyk, P.; Hein, J.; Brumer, H.
Two Fusarium copper radical oxidases with high activity on aryl alcohols
Biotechnol. Biofuels
14
138
2021
Fusarium graminearum (E6PBP1), Fusarium graminearum ATCC MYA-4620 (E6PBP1), Fusarium oxysporum f. sp. lycopersici (E6PBN4), Fusarium oxysporum f. sp. lycopersici 4287 (E6PBN4)
Manually annotated by BRENDA team
Tamaru, Y.; Umezawa, K.; Yoshida, M.
Characterization of an aryl-alcohol oxidase from the plant saprophytic basidiomycete Coprinopsis cinerea with broad substrate specificity against aromatic alcohols
Biotechnol. Lett.
40
1077-1086
2018
Coprinopsis cinerea (A0A2Z5WP81), Coprinopsis cinerea
Manually annotated by BRENDA team
Johnson, H.C.; Zhang, S.; Fryszkowska, A.; Ruccolo, S.; Robaire, S.A.; Klapars, A.; Patel, N.R.; Whittaker, A.M.; Huffman, M.A.; Strotman, N.A.
Biocatalytic oxidation of alcohols using galactose oxidase and a manganese(III) activator for the synthesis of islatravir
Org. Biomol. Chem.
19
1620-1625
2021
Fusarium graminearum (P0CS93)
Manually annotated by BRENDA team
Carro, J.; Martinez-Julvez, M.; Medina, M.; Martinez, A.T.; Ferreira, P.
Protein dynamics promote hydride tunnelling in substrate oxidation by aryl-alcohol oxidase
Phys. Chem. Chem. Phys.
19
28666-28675
2017
Pleurotus eryngii (O94219), Pleurotus eryngii
Manually annotated by BRENDA team
Pickl, M.; Jost, E.; Glueck, S.; Faber, K.
Improved biooxidation of Benzyl alcohols catalyzed by the flavoprotein (5-hydroxymethyl)furfural oxidase in organic solvents
Tetrahedron
73
5408-5410
2017
Methylovorus sp. MP688 (E4QP00)
-
Manually annotated by BRENDA team