1.1.99.22: glycerol dehydrogenase (acceptor)

This is an abbreviated version!
For detailed information about glycerol dehydrogenase (acceptor), go to the full flat file.

Reaction

Synonyms

5-keto-D-gluconate-producing enzyme, D-pentonate 4-dehydrogenase, D-sorbitol dehydrogenase subunit SldA, GLD, GLDH, glycerol dehydrogenase, More, NBRC3255_0235, PQQ-dependent GLDH, PQQ-GLDH, PQQ-SLDH, pyrroloquinoline quinone-dependent glycerol dehydrogenase, quinone-dependent glycerol dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.99 With unknown physiological acceptors

                1.1.99.22 glycerol dehydrogenase (acceptor)

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Results	in table
88	AA Sequence
2	CAS Registry Number
4	Cloned(Commentary)
11	Cofactor
4	General Information
3	General Stability
3	Inhibitors
6	KM Value [mM]
13	Localization
7	Metals/Ions
1	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
87	Organism
6	pH Optimum
2	pH Range
1	pH Stability
3	Protein Variants
5	Purification (Commentary)
1	Reaction
3	Reaction Type
21	Reference
2	Source Tissue
1	Specific Activity [micromol/min/mg]
2	Storage Stability
72	Substrates and Products (Substrate)
4	Subunits
39	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]

Substrates Products

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Substrates Products on EC 1.1.99.22 - glycerol dehydrogenase (acceptor)

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(S)-2-hydroxyglutarate + pyrroloquinoline quinone

2-oxoglutarate + pyrroloquinoline quinol

6 entries

(S)-2-hydroxyglutarate + ubiquinone

2-oxoglutarate + ubiquinol

2 entries

adonitol + acceptor

?

2 entries

D-arabitol + 2,6-dichlorophenolindophenol

? + reduced 2,6-dichlorophenolindophenol

2 entries

D-arabitol + 2,6-dichlorophenolindophenol

D-xylulose + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus

M9MJR9

-

760731

-

-

?

D-arabitol + acceptor

?

2 entries

D-arabitol + acceptor

D-xylulose + reduced acceptor

Gluconobacter oxydans

-

-

654267

-

-

?

D-arabonate + 2,6-dichlorophenolindophenol

4-dehydro-D-arabonate + reduced 2,6-dichlorophenolindophenol

4 entries

D-erythronate + 2,6-dichlorophenolindophenol

3-dehydro-D-erythronate + reduced 2,6-dichlorophenolindophenol

4 entries

D-fructose + oxidized 2,6-dichlorophenolindophenol

5-dehydro-D-fructose + reduced 2,6-dichlorophenolindophenol

4 entries

D-gluconate + 2,6-dichlorophenolindophenol

5-dehydro-D-gluconate + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus

M9MJR9

-

760731

-

-

?

D-gluconate + acceptor

5-keto-D-gluconate + reduced acceptor

Gluconobacter oxydans

-

-

654267

-

-

?

D-mannitol + acceptor

D-fructose + reduced acceptor

2 entries

D-psicose + 2,6-dichlorophenolindophenol

5-dehydro-D-psicose + reduced 2,6-dichlorophenolindophenol

4 entries

D-ribitol + 2,6-dichlorophenolindophenol

? + reduced 2,6-dichlorophenolindophenol

3 entries

D-ribonate + 2,6-dichlorophenolindophenol

4-dehydro-D-ribonate + reduced 2,6-dichlorophenolindophenol

2 entries

D-sorbitol + 2,6-dichlorophenolindophenol

? + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus

-

-

740188

-

-

?

D-sorbitol + 2,6-dichlorophenolindophenol

L-sorbose + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus

M9MJR9

-

760731

-

-

?

D-sorbitol + acceptor

L-sorbose + reduced acceptor

5 entries

galactitol + acceptor

?

Gluconobacter oxydans

-

i.e. dulcitol, 29% of activity with glycerol

287791

-

-

?

glycerol + 2,6-dichlorophenolindophenol

dihydroxyacetone + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus

M9MJR9

-

760731

-

-

?

glycerol + 2,6-dichlorophenolindophenol

glycerone + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus

-

-

740188

-

-

?

glycerol + acceptor

dihydroxyacetone + reduced acceptor

Gluconobacter oxydans

-

-

654267

-

-

?

glycerol + acceptor

glycerone + reduced acceptor

2 entries

glycerol + NAD+

dihydroxyacetone + NADH + H+

2 entries

glycerol + phenazine methosulfate

glycerone + reduced phenazine methosulfate

Gluconobacter thailandicus

-

-

740188

-

-

?

glycerol + potassium ferricyanide

glycerone + potassium ferrocyanide

Gluconobacter thailandicus

-

-

740188

-

-

?

meso-erythritol + acceptor

?

2 entries

meso-erythritol + acceptor

L-erythrulose + reduced acceptor

Gluconobacter oxydans

-

-

654267

-

-

?

propylene glycol + acceptor

?

Gluconobacter oxydans

-

54% of activity with glycerol

287791

-

-

?

ribitol + acceptor

? + reduced acceptor

Gluconobacter oxydans

-

-

654267

-

-

?

additional information

?

-

7 entries

(S)-2-hydroxyglutarate + pyrroloquinoline quinone

2-oxoglutarate + pyrroloquinoline quinol

Gluconobacter frateurii

-

-

721386

-

-

?

(S)-2-hydroxyglutarate + pyrroloquinoline quinone

2-oxoglutarate + pyrroloquinoline quinol

Gluconobacter frateurii

-

coupling with 2,6-dichlorophenolindophenol

721386

-

-

?

(S)-2-hydroxyglutarate + pyrroloquinoline quinone

2-oxoglutarate + pyrroloquinoline quinol

Gluconobacter frateurii CHM43, NBRC 101659

-

-

721386

-

-

?

(S)-2-hydroxyglutarate + pyrroloquinoline quinone

2-oxoglutarate + pyrroloquinoline quinol

Gluconobacter frateurii CHM43, NBRC 101659

-

coupling with 2,6-dichlorophenolindophenol

721386

-

-

?

(S)-2-hydroxyglutarate + pyrroloquinoline quinone

2-oxoglutarate + pyrroloquinoline quinol

Gluconobacter oxydans

-

-

721866

-

-

?

(S)-2-hydroxyglutarate + pyrroloquinoline quinone

2-oxoglutarate + pyrroloquinoline quinol

Gluconobacter oxydans NBRC12528

-

-

721866

-

-

?

(S)-2-hydroxyglutarate + ubiquinone

2-oxoglutarate + ubiquinol

Gluconobacter oxydans

-

-

721866

-

-

?

(S)-2-hydroxyglutarate + ubiquinone

2-oxoglutarate + ubiquinol

Gluconobacter oxydans NBRC12528

-

-

721866

-

-

?

adonitol + acceptor

?

Gluconobacter oxydans

-

42% of activity with glycerol

287791

-

-

?

adonitol + acceptor

?

Gluconobacter oxydans IFO 3260

-

42% of activity with glycerol

287791

-

-

?

D-arabitol + 2,6-dichlorophenolindophenol

? + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus

-

-

740188

-

-

?

D-arabitol + 2,6-dichlorophenolindophenol

? + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus NBRC 3258

-

-

740188

-

-

?

D-arabitol + acceptor

?

Gluconobacter oxydans

-

136% of activity with glycerol oxidation

287791

-

-

?

D-arabitol + acceptor

?

Gluconobacter oxydans IFO 3260

-

136% of activity with glycerol oxidation

287791

-

-

?

D-arabonate + 2,6-dichlorophenolindophenol

4-dehydro-D-arabonate + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus

-

-

740188

-

-

?

D-arabonate + 2,6-dichlorophenolindophenol

4-dehydro-D-arabonate + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus

M9MJR9

-

760731

-

-

?

D-arabonate + 2,6-dichlorophenolindophenol

4-dehydro-D-arabonate + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus NBRC 3255

M9MJR9

-

760731

-

-

?

D-arabonate + 2,6-dichlorophenolindophenol

4-dehydro-D-arabonate + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus NBRC 3258

-

-

740188

-

-

?

D-erythronate + 2,6-dichlorophenolindophenol

3-dehydro-D-erythronate + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus

-

-

740188

-

-

?

D-erythronate + 2,6-dichlorophenolindophenol

3-dehydro-D-erythronate + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus

M9MJR9

-

760731

-

-

?

D-erythronate + 2,6-dichlorophenolindophenol

3-dehydro-D-erythronate + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus NBRC 3255

M9MJR9

-

760731

-

-

?

D-erythronate + 2,6-dichlorophenolindophenol

3-dehydro-D-erythronate + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus NBRC 3258

-

-

740188

-

-

?

D-fructose + oxidized 2,6-dichlorophenolindophenol

5-dehydro-D-fructose + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus

-

-

740188

-

-

?

D-fructose + oxidized 2,6-dichlorophenolindophenol

5-dehydro-D-fructose + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus

M9MJR9

-

760731

-

-

?

D-fructose + oxidized 2,6-dichlorophenolindophenol

5-dehydro-D-fructose + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus NBRC 3255

M9MJR9

-

760731

-

-

?

D-fructose + oxidized 2,6-dichlorophenolindophenol

5-dehydro-D-fructose + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus NBRC 3258

-

-

740188

-

-

?

D-mannitol + acceptor

D-fructose + reduced acceptor

Gluconobacter oxydans

-

-

654267

-

-

?

D-mannitol + acceptor

D-fructose + reduced acceptor

Gluconobacter oxydans

-

26% of activity with glycerol

287791

-

287791

?

D-psicose + 2,6-dichlorophenolindophenol

5-dehydro-D-psicose + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus

-

-

740188

-

-

?

D-psicose + 2,6-dichlorophenolindophenol

5-dehydro-D-psicose + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus

M9MJR9

-

760731

-

-

?

D-psicose + 2,6-dichlorophenolindophenol

5-dehydro-D-psicose + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus NBRC 3255

M9MJR9

-

760731

-

-

?

D-psicose + 2,6-dichlorophenolindophenol

5-dehydro-D-psicose + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus NBRC 3258

-

-

740188

-

-

?

D-ribitol + 2,6-dichlorophenolindophenol

? + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus

-

-

740188

-

-

?

D-ribitol + 2,6-dichlorophenolindophenol

? + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus

M9MJR9

-

760731

-

-

?

D-ribitol + 2,6-dichlorophenolindophenol

? + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus NBRC 3255

M9MJR9

-

760731

-

-

?

D-ribonate + 2,6-dichlorophenolindophenol

4-dehydro-D-ribonate + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus

-

-

740188

-

-

?

D-ribonate + 2,6-dichlorophenolindophenol

4-dehydro-D-ribonate + reduced 2,6-dichlorophenolindophenol

Gluconobacter thailandicus

M9MJR9

-

760731

-

-

?

D-sorbitol + acceptor

L-sorbose + reduced acceptor

Gluconobacter frateurii

-

-

685690

-

-

?

D-sorbitol + acceptor

L-sorbose + reduced acceptor

Gluconobacter frateurii THD32

-

-

685690

-

-

?

D-sorbitol + acceptor

L-sorbose + reduced acceptor

Gluconobacter oxydans

-

-

654267

-

-

?

D-sorbitol + acceptor

L-sorbose + reduced acceptor

Gluconobacter oxydans

-

45% of acticvity with glycerol

287791

-

287791

?

D-sorbitol + acceptor

L-sorbose + reduced acceptor

Gluconobacter oxydans IFO 3260

-

45% of acticvity with glycerol

287791

-

287791

?

glycerol + acceptor

glycerone + reduced acceptor

Gluconobacter oxydans

-

2,6-dichlorophenolindophenol/phenazine methosulfate act as in vitro acceptor, broad specificity, no substrates are: xylitol, D-fructose, D-glucose, D-gluconate, 2-keto-D-gluconate, ethanol and acetaldehyde

287791

i.e. dihydroxyacetone

287791

?

glycerol + acceptor

glycerone + reduced acceptor

Gluconobacter oxydans IFO 3260

-

2,6-dichlorophenolindophenol/phenazine methosulfate act as in vitro acceptor, broad specificity, no substrates are: xylitol, D-fructose, D-glucose, D-gluconate, 2-keto-D-gluconate, ethanol and acetaldehyde

287791

i.e. dihydroxyacetone

287791

?

glycerol + NAD+

dihydroxyacetone + NADH + H+

Escherichia coli

-

-

668061, 674959

-

-

?

glycerol + NAD+

dihydroxyacetone + NADH + H+

Escherichia coli JM109

-

-

668061, 674959

-

-

?

meso-erythritol + acceptor

?

Gluconobacter oxydans

-

111% of activity with glycerol

287791

-

-

?

meso-erythritol + acceptor

?

Gluconobacter oxydans IFO 3260

-

111% of activity with glycerol

287791

-

-

?

additional information

?

-

Gluconobacter frateurii

-

PQQ-GLDH plays a major role in L-sorbose production

685690

-

-

?

additional information

?

-

Gluconobacter frateurii

-

the enzyme shows ubiquinol-2 oxidase activity

721386

-

-

?

additional information

?

-

Gluconobacter frateurii CHM43, NBRC 101659

-

the enzyme shows ubiquinol-2 oxidase activity

721386

-

-

?

additional information

?

-

Gluconobacter frateurii THD32

-

PQQ-GLDH plays a major role in L-sorbose production

685690

-

-

?

additional information

?

-

Gluconobacter oxydans

-

production of 5-keto-D-gluconate is solely dependent on enzyme

654267

-

-

?

additional information

?

-

Gluconobacter sp.

-

broad substrate specificity but high regio- and stereospecificity

695781

-

-

?

additional information

?

-

Gluconobacter sp. THE42

-

broad substrate specificity but high regio- and stereospecificity

695781

-

-

?