1.1.99.30: 2-oxo-acid reductase
This is an abbreviated version!
For detailed information about 2-oxo-acid reductase, go to the full flat file.
Reaction
Synonyms
(2R)-hydroxycarboxlate viologen oxidoreductase, (2R)-hydroxycarboxlate-viologen-oxidoreductase, (2R)-hydroxycarboxylate-viologen-oxidoreductase, 2-oxoacid reductase, D-2-hydroxy acid dehydrogenase, dehydrogenase, D-2-hydroxy acid, HVOR, hydroxy carboxylate viologen oxidoreductase, hydroxycarboxlate-oxidoreductase, hydroxycarboxlate-viologen-oxidoreductase
ECTree
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Reaction
Reaction on EC 1.1.99.30 - 2-oxo-acid reductase
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a (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor
mechanism
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a (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor
Contains [4Fe-4S] and a mononucleotide molybdenum (pyranopterin) cofactor. Has broad substrate specificity, with 2-oxo-monocarboxylates and 2-oxo-dicarboxylates acting as substrates. Branching in a substrate at the C-3 position results in loss of activity. The enzyme from Proteus sp. is inactivated by oxygen
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a (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor
aldonates and aldarates with an (R)-configured alpha-carbon atom are converted to the corresponding 2-oxocarboxylates
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