1.1.99.37: methanol dehydrogenase (nicotinoprotein)
This is an abbreviated version!
For detailed information about methanol dehydrogenase (nicotinoprotein), go to the full flat file.
Word Map on EC 1.1.99.37
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1.1.99.37
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thermotolerant
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formaldehyde
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methanolicus
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rump
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methanol-limited
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decameric
- 1.1.99.37
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thermotolerant
- formaldehyde
- methanolicus
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rump
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methanol-limited
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decameric
Reaction
Synonyms
MDH, MDO, methanol:N,N-dimethyl-4-nitrosoaniline oxidoreductase, NAD-dependent methanol dehydrogenase, NDMA-dependent methanol dehydrogenase
ECTree
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Engineering
Engineering on EC 1.1.99.37 - methanol dehydrogenase (nicotinoprotein)
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D100N
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lacks most of the bound cofactor NAD(H) and has lost all coenzyme NAD+-dependent MDH activity
G95A
K103R
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lacks most of the bound cofactor NAD(H) and has lost all coenzyme NAD+-dependent MDH activity
S97G
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impaired in cofactor NAD(H) binding but retains coenzyme NAD+-dependent MDH activity
G95A
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low MDH activity, 10fold decrease in affinity for NAD+/NADH, insensitive to activator protein
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impaired in cofactor NAD(H) binding but retains coenzyme NAD+-dependent MDH activity
S97G
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insensitive to activator protein, but displays fully activated MDH reaction rates