1.1.99.6: D-lactate dehydrogenase (acceptor)
This is an abbreviated version!
For detailed information about D-lactate dehydrogenase (acceptor), go to the full flat file.
Word Map on EC 1.1.99.6
-
1.1.99.6
-
l-2-hydroxy
-
dl-methionine
-
archaeon
-
hyperthermophilic
-
archaeoglobus
-
dl-met
-
fulgidus
-
fad
-
tokodaii
-
subterraneum
-
candidatus
-
flavin
-
tracer
-
sulfolobus
-
aeropyrum
-
pernix
-
dihydrolipoamide
-
l-isomer
-
analysis
-
diagnostics
-
synthesis
- 1.1.99.6
-
l-2-hydroxy
- dl-methionine
- archaeon
-
hyperthermophilic
-
archaeoglobus
-
dl-met
- fulgidus
- fad
- tokodaii
- subterraneum
-
candidatus
- flavin
-
tracer
-
sulfolobus
-
aeropyrum
- pernix
- dihydrolipoamide
-
l-isomer
- analysis
- diagnostics
- synthesis
Reaction
Synonyms
AF0394, APE_0487, CSUB_C1080, D-2-hydroxy acid dehydrogenase, dehydrogenase, D-2-hydroxy acid, Dld enzyme, dye-DLDH, dye-linked D-lactate dehydrogenase, ST0649, TTX_0794
ECTree
1.1.99.6 D-lactate dehydrogenase (acceptor)Advanced search results
results (
results (Substrates Products
Substrates Products on EC 1.1.99.6 - D-lactate dehydrogenase (acceptor)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(R)-2-hydroxybutanoate + 2,6-dichlorophenolindophenol
2-oxobutanoate + reduced 2,6-dichlorophenolindophenol
preferred substrate
-
-
?
(R)-2-hydroxybutyrate + oxidized 2,6-dichlorophenolindophenol
2-oxobutyrate + reduced 2,6-dichlorophenolindophenol
(R)-lactate + 2,6-dichlorophenolindophenol
pyruvate + reduced 2,6-dichlorophenolindophenol
preferred substrate
-
-
?
(R)-lactate + ferricyanide
pyruvate + ferrocyanide + H+
-
-
-
?
(R)-lactate + oxidized 2,6-dichlorophenolindophenol
pyruvate + reduced 2,6-dichlorophenolindophenol
(R)-lactate + oxidized 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium
pyruvate + reduced 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium
-
-
-
?
(R)-lactate + oxidized 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide
pyruvate + reduced 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide
2(R)-hydroxybutanoate + acceptor
2-oxobutanoate + reduced acceptor
-
-
-
?
2(R)-hydroxyheptanoate + acceptor
2-oxoheptanoate + reduced acceptor
-
-
-
?
2(R)-hydroxyhexanoate + acceptor
2-oxohexanoate + reduced acceptor
-
-
-
?
2(R)-hydroxyoctanoate + acceptor
2-oxooctanoate + reduced acceptor
-
-
-
?
2(R)-hydroxypentanoate + acceptor
2-oxopentanoate + reduced acceptor
-
-
-
?
D-glycerate + acceptor
hydroxypyruvate + reduced acceptor
-
-
-
?
D-lactate + 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide
pyruvate + reduced 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide
D-lactate + phenazine methosulfate p-iodonitrotetrazolium
pyruvate + reduced phenazine methosulfate p-iodonitrotetrazolium
-
-
-
?
D-tartrate + acceptor
2-oxo-3-hydroxybutanoate + reduced acceptor
-
poor substrate
-
?
meso-tartrate + acceptor
2-oxo-3-hydroxybutanoate + reduced acceptor
-
good substrate
-
?
phenylpyruvate + reduced acceptor
phenyl-(R)-lactate + acceptor
-
-
-
r
(R)-2-hydroxybutyrate + oxidized 2,6-dichlorophenolindophenol
2-oxobutyrate + reduced 2,6-dichlorophenolindophenol
relative activity is 46% compared to D-lactate
-
-
?
(R)-2-hydroxybutyrate + oxidized 2,6-dichlorophenolindophenol
2-oxobutyrate + reduced 2,6-dichlorophenolindophenol
97% of the activity compared to (R)-lactate
-
-
?
(R)-2-hydroxybutyrate + oxidized 2,6-dichlorophenolindophenol
2-oxobutyrate + reduced 2,6-dichlorophenolindophenol
97% of the activity compared to (R)-lactate
-
-
?
(R)-lactate + 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide
pyruvate + ?
-
-
-
?
(R)-lactate + 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide
pyruvate + ?
Aeropyrum pernix ATCC 700893
-
-
-
?
(R)-lactate + 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide
pyruvate + ?
-
-
-
?
(R)-lactate + acceptor
pyruvate + reduced acceptor
-
-
-
?
(R)-lactate + acceptor
pyruvate + reduced acceptor
-
cytochrome c, ubiquinone and O2 are possible physiological acceptors
-
?
(R)-lactate + acceptor
pyruvate + reduced acceptor
-
no activity with glycolate, 3-methylpentanoate, phenylglycolate, phenyllactate, 3-phosphoglycerate, 6-phosphoglycerate
-
?
(R)-lactate + acceptor
pyruvate + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate, ferricyanide
-
?
(R)-lactate + acceptor
pyruvate + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate, ferricyanide
-
?
(R)-lactate + acceptor
pyruvate + reduced acceptor
-
enzyme acts on a variety of (R)-2-hydroxy acids
-
?
(R)-lactate + acceptor
pyruvate + reduced acceptor
-
enzyme acts on a variety of (R)-2-hydroxy acids
-
?
(R)-lactate + acceptor
pyruvate + reduced acceptor
-
cytochrome c, ubiquinone and O2 are possible physiological electron acceptors
-
?
(R)-lactate + ferricyanide
pyruvate + ferrocyanide
ferricyanide is the preferred electron acceptor
-
-
?
(R)-lactate + ferricyanide
pyruvate + ferrocyanide
ferricyanide is the preferred electron acceptor
-
-
?
(R)-lactate + oxidized 2,6-dichlorophenolindophenol
pyruvate + reduced 2,6-dichlorophenolindophenol
-
-
-
?
(R)-lactate + oxidized 2,6-dichlorophenolindophenol
pyruvate + reduced 2,6-dichlorophenolindophenol
Aeropyrum pernix ATCC 700893
-
-
-
?
(R)-lactate + oxidized 2,6-dichlorophenolindophenol
pyruvate + reduced 2,6-dichlorophenolindophenol
no activity with L-lactate
-
-
?
(R)-lactate + oxidized 2,6-dichlorophenolindophenol
pyruvate + reduced 2,6-dichlorophenolindophenol
(R)-lactate is the most preferred substrate, followed by (R)-2-hydroxybutyrate. D-Alanine, pyruvate, D-glucose, L-alanine, ethanol and L-lactate are inert as electron donors. Benzyl viologen and methylene blue are inert as electron acceptors
-
-
?
(R)-lactate + oxidized 2,6-dichlorophenolindophenol
pyruvate + reduced 2,6-dichlorophenolindophenol
activity is 59% compared to the activity with ferricyanide
-
-
?
(R)-lactate + oxidized 2,6-dichlorophenolindophenol
pyruvate + reduced 2,6-dichlorophenolindophenol
activity is 59% compared to the activity with ferricyanide
-
-
?
(R)-lactate + oxidized 2,6-dichlorophenolindophenol
pyruvate + reduced 2,6-dichlorophenolindophenol
-
-
-
?
(R)-lactate + oxidized 2,6-dichlorophenolindophenol
pyruvate + reduced 2,6-dichlorophenolindophenol
Thermoproteus tenax ATCC 35583
-
-
-
?
(R)-lactate + oxidized 2,6-dichlorophenolindophenol
pyruvate + reduced 2,6-dichlorophenolindophenol
-
-
-
?
(R)-lactate + oxidized 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide
pyruvate + reduced 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide
-
-
-
?
(R)-lactate + oxidized 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide
pyruvate + reduced 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide
activity is 29% compared to the activity with ferricyanide
-
-
?
(R)-lactate + oxidized 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide
pyruvate + reduced 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide
activity is 29% compared to the activity with ferricyanide
-
-
?
(R)-lactate + phenazine methosulfate p-iodonitrotetrazolium
pyruvate + ?
-
-
-
?
(R)-lactate + phenazine methosulfate p-iodonitrotetrazolium
pyruvate + ?
Aeropyrum pernix ATCC 700893
-
-
-
?
D-lactate + 2,6-dichloroindophenol
pyruvate + reduced 2,6-dichloroindophenol
-
-
-
?
D-lactate + 2,6-dichloroindophenol
pyruvate + reduced 2,6-dichloroindophenol
Thermoproteus tenax ATCC 35583
-
-
-
?
D-lactate + 2,6-dichloroindophenol
pyruvate + reduced 2,6-dichloroindophenol
-
-
-
?
D-lactate + 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide
pyruvate + reduced 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide
-
-
-
?
D-lactate + 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide
pyruvate + reduced 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide
Thermoproteus tenax ATCC 35583
-
-
-
?
D-lactate + 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide
pyruvate + reduced 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide
-
-
-
?
additional information
?
-
D-glycerate, D-alanine, D-leucine, 2-hydroxyisobutyrate, L-lactate, L-alanine, and L-leucine are inert as the electron donor. Ferricyanide, benzyl viologen, and methylene blue are inert as electron acceptors
-
-
-
additional information
?
-
-
D-glycerate, D-alanine, D-leucine, 2-hydroxyisobutyrate, L-lactate, L-alanine, and L-leucine are inert as the electron donor. Ferricyanide, benzyl viologen, and methylene blue are inert as electron acceptors
-
-
-
additional information
?
-
Aeropyrum pernix ATCC 700893
D-glycerate, D-alanine, D-leucine, 2-hydroxyisobutyrate, L-lactate, L-alanine, and L-leucine are inert as the electron donor. Ferricyanide, benzyl viologen, and methylene blue are inert as electron acceptors
-
-
-
additional information
?
-
the enzyme is expressed constitutively
-
-
?
additional information
?
-
methylene blue, dimethylnaphthoquinone, NAD+, and horse heart cytochrome c do not serve as electron acceptors for the purified enzyme
-
-
?
additional information
?
-
-
methylene blue, dimethylnaphthoquinone, NAD+, and horse heart cytochrome c do not serve as electron acceptors for the purified enzyme
-
-
?
additional information
?
-
no substrates: D-alanine, pyruvate, D-glucose, L-alanine, ethanol and L-lactate
-
-
-
additional information
?
-
-
no substrates: D-alanine, pyruvate, D-glucose, L-alanine, ethanol and L-lactate
-
-
-
additional information
?
-
L-lactate, glycolate, L-tartrate, citrate, glyoxylate, 2-hydroxyisobutyrate, D-glycerate and D-2-phosphoglycerate are inert as electron donors. Benzyl viologen and methylene blue are inert as electron acceptors
-
-
?
additional information
?
-
-
L-lactate, glycolate, L-tartrate, citrate, glyoxylate, 2-hydroxyisobutyrate, D-glycerate and D-2-phosphoglycerate are inert as electron donors. Benzyl viologen and methylene blue are inert as electron acceptors
-
-
?
additional information
?
-
L-lactate, glycolate, L-tartrate, citrate, glyoxylate, 2-hydroxyisobutyrate, D-glycerate and D-2-phosphoglycerate are inert as electron donors. Benzyl viologen and methylene blue are inert as electron acceptors
-
-
?
additional information
?
-
no acceptors: ferricyanide, benzyl viologen, and methylene blue
-
-
-
additional information
?
-
-
no acceptors: ferricyanide, benzyl viologen, and methylene blue
-
-
-
additional information
?
-
D-glycerate, D-alanine, D-leucine, 2-hydroxyisobutyrate, L-lactate, L-alanine, and L-leucine are inert as the electron donor. Ferricyanide, benzyl viologen, and methylene blue are inert as electron acceptors
-
-
-
additional information
?
-
-
D-glycerate, D-alanine, D-leucine, 2-hydroxyisobutyrate, L-lactate, L-alanine, and L-leucine are inert as the electron donor. Ferricyanide, benzyl viologen, and methylene blue are inert as electron acceptors
-
-
-
additional information
?
-
Thermoproteus tenax ATCC 35583
no acceptors: ferricyanide, benzyl viologen, and methylene blue
-
-
-
additional information
?
-
Thermoproteus tenax ATCC 35583
D-glycerate, D-alanine, D-leucine, 2-hydroxyisobutyrate, L-lactate, L-alanine, and L-leucine are inert as the electron donor. Ferricyanide, benzyl viologen, and methylene blue are inert as electron acceptors
-
-
-
additional information
?
-
no acceptors: ferricyanide, benzyl viologen, and methylene blue
-
-
-
additional information
?
-
D-glycerate, D-alanine, D-leucine, 2-hydroxyisobutyrate, L-lactate, L-alanine, and L-leucine are inert as the electron donor. Ferricyanide, benzyl viologen, and methylene blue are inert as electron acceptors
-
-
-
