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1.10.3.1: catechol oxidase

This is an abbreviated version!
For detailed information about catechol oxidase, go to the full flat file.

Word Map on EC 1.10.3.1

Reaction

2 catechol +

O2
= 2 1,2-benzoquinone + 2 H2O

Synonyms

1,2-benzene: oxygen oxidoreductase, 1,2-benzenediol:oxygen oxidoreductase, AoCO4, catalase-phenol oxidase, catechol oxidase, catecholase, catecholoxidase, CATPO, CO, copper-S100B, cresolase, dihydroxy-L-phenylalanine:oxygen oxidoreductase, Diphenol oxidase, diphenolase, dopa oxidase, germin-like protein, GLP, hemocyanin, ibCO, LsPPO, mettyrosinase, monophenol, o-diphenol: oxygen oxidoreductase, monophenol, o-diphenol:oxygen oxidoreductase, More, MppO, o-diphenol oxidoreductase, o-diphenol: dioxygen oxidoreductase, dehydrogenating, o-diphenol:oxygen oxidoreductase, o-diphenolase, o-diphenoloxidase, oxytyrosinase, phenol oxidase, phenolase, phenoloxidase, polyphenol oxidase, polyphenoloxidase, PPO, PPO 1, PPO 2, PPO II, PPO-6, pyrocatechol oxidase, TYR3, tyrosinase

ECTree

     1 Oxidoreductases
         1.10 Acting on diphenols and related substances as donors
             1.10.3 With oxygen as acceptor
                1.10.3.1 catechol oxidase

IC50 Value

IC50 Value on EC 1.10.3.1 - catechol oxidase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3.7
2,3-Dihydroxybenzoic acid
Lablab purpureus
-
-
0.55
2,4-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide
Agaricus bisporus
-
IC50: 0.550 mM
1.82
2,4-dihydroxy-N-(4-hydroxybenzyl)benzamide
Agaricus bisporus
-
IC50: 1.820 mM
0.00351
2-methyl-4-[(E)-(4-nitrophenyl)methylidene]-1,3-oxazol-5(4H)-one
Agaricus bisporus
-
IC50: 0.00351 mM
0.00311
2-methyl-4-[(E)-2-thienylmethylidene]-1,3-oxazol-5-one
Agaricus bisporus
-
IC50: 0.00311 mM
0.00123
2-methyl-4-[(E,2Z)-3-phenyl-2-propenyliden]-1,3-oxazol-5(4H)-one
Agaricus bisporus
-
IC50: 0.00123 mM
0.555
3,4,5-trihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide
Agaricus bisporus
-
IC50: 0.555 mM
1.18
3,4,5-trihydroxy-N-(4-hydroxybenzyl)benzamide
Agaricus bisporus
-
IC50: 1.180 mM
3.8
3,4,5-Trihydroxybenzoic acid
Lablab purpureus
-
-
0.28
3,4-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide
Agaricus bisporus
-
IC50: 0.280 mM
2
3,4-dihydroxy-N-(4-hydroxybenzyl)benzamide
Agaricus bisporus
-
IC50: 2.0 mM
2.8
3,4-dihydroxybenzoic acid
Lablab purpureus
-
-
0.705
3,5-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide
Agaricus bisporus
-
IC50: 0.705 mM
0.71
3,5-dihydroxy-N-(4-hydroxybenzyl)benzamide
Agaricus bisporus
-
IC50: 0.710 mM
0.00215
3-(acetoyloxy)-2-hydroxy-4-[[5-oxo-2-phenyl-1,3-oxazol-4(5H)-ylidene]methyl]phenylacetate
Agaricus bisporus
-
IC50: 0.00215 mM
0.0021
3-aminophenyl-2,2'-methylenebis-(5,5-dimethylcyclohexane-1,3-dione)
Agaricus bisporus
-
IC50: 0.0021 mM
0.00219
3-aminophenyl-2,2'-methylenebis-(cyclohexane-1,3-dione)
Agaricus bisporus
-
IC50: 0.00219 mM
0.0032
3-chlorophenyl-2,2'-methylenebis-(5,5-dimethylcyclohexane-1,3-dione)
Agaricus bisporus
-
IC50: 0.0032 mM
0.00323
4-[(E)-(4-nitrophenyl)methylidene]-2-phenyl-1,3-oxazol-5(4H)-one
Agaricus bisporus
-
IC50: 0.00323 mM
0.32
Anisaldehyde
0.045 - 0.06
ascorbate
0.33
ascorbic acid
Cynara cardunculus var. scolymus
-
competitive with pyrolallol or catechol, noncompetitive with 4-methylcatechol as substrate. IC50: 0.357 mM in reaction with 4-methylcatechol, IC50: 0.818 mM in reaction with pyrogallol, IC50: 0.33 mM in reaction with catechol
0.014
askendoside B
Agaricus bisporus
-
IC50 : 0.014 mM
1.2
benzoic acid
Lablab purpureus
-
-
0.49
beta-mercaptoethanol
Lactarius salmonicolor
-
-
3.56 - 30.96
CaCl2
0.05
cuminaldehyde
0.135
DL-dithiothreitol
Cynara cardunculus var. scolymus
-
competitive with 4-methylcatechol, catechol or pyrogallol. IC50: 0.147 mM in reaction with 4-methylcatechol, IC50: 0.0329 mM in reaction with pyrogallol, IC50: 0.135 mM in reaction with catechol
0.536 - 0.632
fukugiside
7.6
glabrene
0.004
glabridin
0.323 - 0.91
glutathione
0.044 - 0.563
hydroquinone
0.047
isoliquiritigenin
0.014 - 0.0163
kojic acid
0.15
L-Cys
Cynara cardunculus var. scolymus
-
competitive with 4-methylcatechol, catechol or pyrogallol. IC50: 0.125 mM in reaction with 4-methylcatechol, IC50: 0.637 mM in reaction with pyrogallol, IC50: 0.15 mM in reaction with catechol
0.044 - 0.15
L-cysteine
0.00368
L-mimosine
Agaricus bisporus
-
IC50: 0.00368 mM
0.00038
L-tyrosine
Lactarius salmonicolor
-
-
0.19
luteolin
0.5
luteolin 7-O-glucoside
1.1
m-hydroxybenzoic acid
Lablab purpureus
-
-
2.32
morin
Beta vulgaris
-
competitive, IC50: 2.320 mM
0.029
N-(2,4-dihydroxybenzyl)-2,4-dihydroxybenzamide
Agaricus bisporus
-
IC50: 0.029 mM
0.017
N-(2,4-dihydroxybenzyl)-3,4,5-trihydroxybenzamide
Agaricus bisporus
-
IC50: 0.017 mM
0.011
N-(2,4-dihydroxybenzyl)-3,4-dihydroxybenzamide
Agaricus bisporus
-
IC50: 0.011 mM
0.0022
N-(2,4-dihydroxybenzyl)-3,5-dihydroxybenzamide
Agaricus bisporus
-
IC50: 0.0022 mM
1.66
N-benzyl-2,4-dihydroxybenzamide
Agaricus bisporus
-
IC50: 1.660 mM
0.78
N-benzyl-3,4,5-trihydroxybenzamide
Agaricus bisporus
-
IC50: 0.780 mM
2
N-benzyl-3,4-dihydroxybenzamide
Agaricus bisporus
-
IC50: 2.0 mM
0.7
N-benzyl-3,5-dihydroxybenzamide
Agaricus bisporus
-
IC50: 0.700 mM
1.99
N-benzylamide
Agaricus bisporus
-
IC50: 1.990 mM
5.01 - 39.54
NaCl
3.6
o-hydroxybenzoic acid
Lablab purpureus
-
-
0.12
oxalic acid
Lactarius salmonicolor
-
-
0.23
p-aminobenzenesulfonamide
Lactarius salmonicolor
-
-
1.3
p-hydroxybenzoic acid
Lablab purpureus
-
-
0.0026
phenyl-2,2'-methylenebis-(5,5-dimethylcyclohexane-1,3-dione)
Agaricus bisporus
-
IC50: 0.0026 mM
0.043 - 0.07
Phenylthiourea
0.002 - 0.2
quercetin
4.32
Sodium azide
Cynara cardunculus var. scolymus
-
competitive with 4-methylcatechol or pyrogallol, noncompetitive with catechol as substrate. IC50: 1.31 mM in reaction with 4-methylcatechol, IC50: 10.3 mM in reaction with pyrogallol, IC50: 4.32 mM in reaction with catechol
0.15 - 0.157
sodium sulfite
0.4
syringic acid
Lactarius salmonicolor
-
-
0.062 - 0.372
Tannic acid
0.0297
tropolone
Cynara cardunculus var. scolymus
-
competitive with pyrolallol or catechol, noncompetitive with 4-methylcatechol. IC50: 0.0109 mM in reaction with 4-methylcatechol, IC50: 0.0539 mM in reaction with pyrogallol, IC50: 0.0297 mM in reaction with catechol