Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.11.1.8: iodide peroxidase

This is an abbreviated version!
For detailed information about iodide peroxidase, go to the full flat file.

Word Map on EC 1.11.1.8

Reaction

2 iodide +

H2O2
+ 2 H+ =
diiodine
 + 2 H2O

Synonyms

bromoperoxidase, high-molecular weight-thyroid peroxidase, HMW-TPO, hrTPO, hTPO, iodide peroxidase-tyrosine iodinase, iodinase, iodoperoxidase (heme type), thyroid peroxidase, thyroperoxidase, TPO, TPOX, TPQ, tyrosine iodinase, vanadium bromoperoxidase, vBPO

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.8 iodide peroxidase

Localization

Localization on EC 1.11.1.8 - iodide peroxidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
in Graves‘ disease, the nuclear envelope, enlarged rough endoplasmic reticulum, and apical vesicles are strongly TPO positive
Manually annotated by BRENDA team
-
wild-type enzyme and mutant enzymes G614A, G1687T, 1808-13del, C2083, G2401A
Manually annotated by BRENDA team
-
of Graves‘ disease thyroid, enzyme is absent in the microvilli in multinodular goiter
Manually annotated by BRENDA team
-
in the perinodular normal tissue the enzyme is detected mainly in the nuclear envelope, rough endoplasmic reticulum, and subapical vesicles. In cells from Hashimoto‘s thyroiditis detected in scarce rough endoplasmic reticulum. In Graves‘ disease, the nuclear envelope, enlarged rough endoplasmic reticulum, and apical vesicles are strongly TPO positive
Manually annotated by BRENDA team
-
in Graves' disease, the nuclear envelope, enlarged rough endoplasmic reticulum, and apical vesicles are strongly TPO positive, in the perinodular normal tissue the enzyme is detected mainly in the nuclear envelope, rough endoplasmic reticulum, and subapical vesicles
Manually annotated by BRENDA team
additional information
-
in the perinodular normal tissue the enzyme is absent in the apical surface, enzyme from multinodular goiter is absent in the microvilli
-
Manually annotated by BRENDA team