1.11.1.9: glutathione peroxidase

This is an abbreviated version!
For detailed information about glutathione peroxidase, go to the full flat file.

Reaction

2 glutathione +

Synonyms

2-SeCD, 3,3'-telluro-bis(proapne-3,1-diyl)adamantane carboxylate, 6P229, ADA-Te-OH, ARMEP24, AtGPX1, ATGPX3, c-GPx4, Cellular glutathione peroxidase, cgd3_460, cGPx, Cuticular glycoprotein GP29, DI29, ebselen, EGLP, Epididymis-specific glutathione peroxidase-like protein, Extracellular glutathione peroxidase, G-6137, Gastrointestinal glutathione peroxidase, glutathione peroxidase 1, glutathione peroxidase 2, glutathione peroxidase 3, glutathione peroxidase 4, glutathione peroxidase Gpx2, glutathione peroxidase Gpx3, glutathione peroxidase-1, glutathione peroxidase-2, glutathione peroxidase-3, glutathione peroxidase-4, glutathione-dependent peroxidase I, glutathione:hydrogen-peroxide oxidoreductase, GP30, GPRP, GPX, Gpx-1, GPx-2, GPx-3, GPx-4, GPx-5, GPx-6, GPx-7, GPx-8, GPX1, Gpx2, GPX3, GPx4, GPX5, GSH peroxidase, GSH-Px, GSHPx, GSHPx-GI, intracellular GpX, m-GPx4, Major androgen-regulated protein, Major surface antigen GP29, n-GPx4, Nt-SubC08, Odorant-metabolizing protein RY2D1, Os02g0664000, OsGPX5, peroxidase, glutathione, PGdx, pGPx, PHGPX, phospholipid glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase, nuclear form, phospholipid hydroperoxide Gpx, plasma glutathione peroxidase, prion protein Ure2, reduced glutathione peroxidase, Salt-associated protein, Se-GPx, Se-hGSTZ1-1, Se-scFv-B3, secreted GpX, SeGPx, selenium containing glutathione transferase zeta1-1, selenium-dependent glutathione peroxidase, selenium-glutathione peroxidase, seleno-dependent glutathione peroxidase 1, selenosubtilisin, snGPx, TcGPXI, TTHERM_00046090, TTHERM_00046110, TTHERM_01099010, Ure2

ECTree

     1 Oxidoreductases

         1.11 Acting on a peroxide as acceptor

             1.11.1 Peroxidases

                1.11.1.9 glutathione peroxidase

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Results	in table
18	Activating Compound
1510	AA Sequence
12	Application
1	CAS Registry Number
29	Cloned(Commentary)
9	Crystallization (Commentary)
13419	Disease/ Diagnostics
27	Expression
20	General Information
7	General Stability
77	Inhibitors
4	kcat/KM [mM/s]
4	Ki Value [mM]
63	KM Value [mM]
90	Localization
62	Metals/Ions
52	Molecular Weight [Da]
122	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
228	Organism
2	Oxidation Stability
7	Pathway
25	PDB ID
20	pH Optimum
5	pH Range
7	pH Stability
4	pI Value
2	Posttranslational Modification
15	Protein Variants
39	Purification (Commentary)
3	Reaction
3	Reaction Type
199	Reference
269	Source Tissue
45	Specific Activity [micromol/min/mg]
8	Storage Stability
253	Substrates and Products (Substrate)
62	Subunits
216	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
5	Temperature Range [°C]
4	Temperature Stability [°C]
23	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.11.1.9 - glutathione peroxidase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

cysteine

Bos taurus

-

cysteine increases activity at low glutathione concentrations

688035

EDTA

Camelus dromedarius

-

2 mM, 128% of initial activity

764056

etoposide

Homo sapiens

-

activates p53, wich induces the expression of glutathione peroxidase

396631

genistein

Homo sapiens

-

-

658933

hyperglycemia

Rattus norvegicus

-

increased GPX1 activity in rat VSM cell. When cells are exposed to high glucose (25 mM) for 48 h, GPX1 activity is 2.5fold greater than in cells grown in normal glucose (5 mM), while the GPX1 expression levels are the same

702092

-

NaN3

Camelus dromedarius

-

2 mM, 131% of initial activity

764056

PMSF

Camelus dromedarius

-

2 mM, 167% of initial activity

764056

reduced glutathione

Piaractus mesopotamicus

-

activated by 2 to 6 mM

685411

SDS

Camelus dromedarius

-

2 mM, 154% of initial activity

764056

Selenite

Rattus norvegicus

-

-

688957

additional information

8 entries

-

additional information

Homo sapiens

-

neither prostate tissue nor serum selenium concentrations are associated with prostate glutathione peroxidase activity

701039

-

additional information

Homo sapiens

-

postmenopausal women have significantly greater plasma GPx activities compared to premenopausal women possibly in response to oxidative processes associated with aging

696581

-

additional information

Homo sapiens

-

thiazolidinediones-mediated activation of peroxisome proliferatoractivated receptor gamma induces gene expression of glutathione peroxidase 3

700167

-

additional information

Hordeum vulgare

-

Cd+- and Hg+-induced root growth inhibition is strongly correlated with increased glutathione peroxidase activity, a slight increase of glutathione peroxidase activity is observed after application of Pb2+, Ni2+, and Zn2+, while Co2+ does not affect glutathione peroxidase activity, GPX activity is not affected by cold, heat or drought treatment and only a slight increase is observed after salt or H2O2 treatment

700785

-

additional information

Mus musculus

-

injection of the O-GlcNAcase inhibitor 1,2-dideoxy-2'-propyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline increases GPX1 activity in the mouse liver

702092

-

additional information

Rattus norvegicus

-

administration of lead acetate (100 and 1000 mg/l for 18 weeks) evokes increase of GPx activity in the kidney of female, but not male rats

695410

-

additional information

Rattus norvegicus

-

systemic oxidative stress long lasting rat pregnancy induces, at seventeen days of pregnancy, an increase of membrane glutathione peroxidase activity

701160

-

additional information

Rattus norvegicus

-

increasing the cellular O-GlcNAcylation level enhances GPX1 activity

702092

-