1.11.2.2: myeloperoxidase

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For detailed information about myeloperoxidase, go to the full flat file.

Word Map on EC 1.11.2.2

1.11.2.2

neutrophil

necrosis

leukocyte

tnf

malondialdehyde

dismutase

colitis

reperfusion

pulmonary

artery

endothelial

polymorphonuclear

ischemia

catalase

monocyte

sham

bowel

lps

mucosal

ulcer

edema

bronchoalveolar

wistar

granulocyte

lavage

lipopolysaccharide

sod

hypochlorous

hocl

vasculitis

ischemia-reperfusion

factor-alpha

macroscopic

tnf-alpha

eosinophil

elastase

dextran

ancas

myeloid

dss-induced

degranulation

glomerulonephritis

lactoferrin

icam-1

granulomatosis

antineutrophil

instil

medicine

carrageenan-induced

lactoperoxidase

crescent

analysis

Reaction

Synonyms

donor, hydrogen peroxide oxidoreductase, donor, hydrogen peroxideoxidoreductase, donor: H2O2 oxidoreductase, donor:H2O2 oxidoreductase, donor:hydrogen peroxide oxidoreductase, donor:hydrogen-peroxide oxidoreductase, EC 1.11.1.7, epx2a, hemi-MPO, hemi-myeloperoxidase, LPO, MPO, MPX, myeloperoxidase, peroxinectin, properoxinectin, recombinant human MPO, rhMPO, tissue myeloperoxidase

ECTree

1 Oxidoreductases

1.11 Acting on a peroxide as acceptor

1.11.2 Peroxygenases

1.11.2.2 myeloperoxidase

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Results	in table
15	Activating Compound
4	AA Sequence
3	Application
4	Cloned(Commentary)
54	Cofactor
3	Crystallization (Commentary)
18939	Disease/ Diagnostics
2	Expression
22	General Information
1	General Stability
147	IC50 Value
266	Inhibitors
9	Ki Value [mM]
35	KM Value [mM]
9	Localization
7	Metals/Ions
16	Molecular Weight [Da]
65	Natural Substrates/ Products (Substrates)
90	Organism
1	Pathway
122	PDB ID
11	pH Optimum
1	pH Range
1	pH Stability
12	Posttranslational Modification
18	Purification (Commentary)
1	Reaction
90	Reference
98	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
190	Substrates and Products (Substrate)
19	Subunits
92	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Temperature Stability [°C]
33	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.11.2.2 - myeloperoxidase

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chloride:hydrogen-peroxide oxidoreductase (hypochlorite-forming)

Contains calcium and covalently bound heme (proximal ligand histidine). It is present in phagosomes of neutrophils and monocytes, where the hypochlorite produced is strongly bactericidal. It differs from EC 1.11.1.10 chloride peroxidase in its preference for formation of hypochlorite over the chlorination of organic substrates under physiological conditions (pH 5-8). Hypochlorite in turn forms a number of antimicrobial products (Cl2, chloramines, hydroxyl radical, singlet oxygen). MPO also oxidizes bromide, iodide and thiocyanate. In the absence of halides, it oxidizes phenols and has a moderate peroxygenase activity toward styrene.