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1.13.11.1: catechol 1,2-dioxygenase

This is an abbreviated version!
For detailed information about catechol 1,2-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.1

Reaction

catechol
+
O2
=
cis,cis-muconate

Synonyms

(chloro-)catechol 1,2-dioxygenase, 1,2 CTD, 1,2-CTD, 1,2-pyrocatechase, 3-chlorocatechol 1,2-dioxygenase, BC-C23O, C1,2-DO, C1,2O, C12, C12D, C12DO, C12O, cat12, CatA, catechase, catechol 1,2 dioxygenase, catechol 1,2-dioxygenase, catechol 1,2-dioxygenase type I, catechol 1,2-dioxygenase type II, catechol 1,2-oxygenase, catechol dioxygenase, catechol oxygenase, catechol-oxygen 1,2-oxidoreductase, catechol:oxygen 1,2-oxidoreductase, CD I, CD II, CD-I, CD-II, CD-III-1, CD-III-2, CDI1, CDI2, chlorocatechol 1,2-dioxygenase, clCA, extradiol dioxygenase MhpB, IsoB, putative catechol 2,3-dioxygenase, pyrocatechase, pyrocatechol 1,2-dioxygenase, TfdC

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.1 catechol 1,2-dioxygenase

Inhibitors

Inhibitors on EC 1.13.11.1 - catechol 1,2-dioxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
progressive inactivation, loss of all activation after 90 min, reactivation with Fe3+
1,2-naphthoquinone
-
-
2,2'-dipyridyl
complete inhibition at 2 mM, 99.9% at 1 mM
2,4-Dichlorophenol
26.0% inhibition at 0.1 mM, 29.8% at 0.3 mM
2-chlorophenol
31.1% inhibition at 0.1 mM, 17% at 0.3 mM
2-mercaptoethanol
2-methylphenol
24.7% inhibition at 0.1 mM
3,4,5,6-tetrachlorocatechol
competitive inhibitor
3,4,5-trichlorocatechol
-
competitive inhibitor
3,5-dichlorocatechol
competitive inhibitor
3-Isopropylcatechol
-
-
3-methylcatechol
3-methylphenol
20.4% inhibition at 0.1 mM, 32% at 0.3 mM
3-methylthiocatechol
-
competitive inhibitor
4,5-dichlorocatechol
4-Chlorophenol
11% inhibition at 0.1 mM, 13% at 0.3 mM
4-methylcatechol
4-Methylphenol
8% inhibition at 0.1 mM, 27.5% at 0.3 mM
4-nitrocatechol
AgNO3
alpha,alpha'-dipyridyl
-
94% inhibition, 1 mM
alpha-chloro-3,4-dihydroxyacetophenone
-
-
catechol
substrate inhibition at over 0.08 mM substrate concentration
Co2+
Stutzerimonas stutzeri
1.3 mM, 30 min, 24% loss of activity
CuCl2
-
0.1 mM, 41% inhibition
CuSO4
-
0.1 mM, 10 min, complete inhibition
dichlorocatechol
-
-
FeCl3
-
0.1 mM, 14% inhibition
FeSO4
-
0.1 mM, 10 min, 12% inhibition
gallic acid
-
-
glutathione
-
-
H2O2
-
0.1 mM, 10 min, 98% inhibition
HgCl2
iodoacetic acid
L-cysteine
-
-
mercaptoethanol
-
0.1 mM, 10 min, 98% inhibition
NaCl
Stutzerimonas stutzeri
increasing NaCl concentration gradually reduce activity. In 0.7 M NaCl quaternary structur changes to a dimeric arrangement and causes a 51% decrease in specific activity on catechol substrate
o-benzoquinone
-
-
o-phenanthroline
p-chloromercuribenzoate
p-hydroxymercuribenzoate
-
-
PbSO4
-
0.1 mM, 75% loss of activity
Phenanthroline
complete inhibition at 3 mM, 99% at 1 mM
SDS
5 mM, complete loss of activity
Sodium dithionite
-
1 mM, 36% loss of activity
streptomycin sulfate
-
5%, 10 min, 80% inhibition
tetrachlorocatechol
-
markedly inhibitory at concentration above 4 microM
Tiron
Triton X100
5 mM, about 90% loss of activity
Tween 20
5 mM, about 50% loss of activity
Vanillin
-
-
additional information
-
not inhibited by Hg2+
-