1.13.11.11: tryptophan 2,3-dioxygenase

This is an abbreviated version!
For detailed information about tryptophan 2,3-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.11

1.13.11.11

indoleamine

kynurenine

immunotherapy

heme

serotonin

checkpoint

l-trp

n-formylkynurenine

quinolinic

tolerogenic

3-monooxygenase

3,4-dioxygenase

heme-containing

2,3-dioxygenase-1

tryptophan-degrading

3-hydroxyanthranilate

indoleamine-2,3-dioxygenase

picolinic

tryptophan-catabolizing

pyrrolase

3-hydroxykynurenine

medicine

drug development

Reaction

Synonyms

33737, BRAFLDRAFT_210874, C28H8.11, EC 1.11.1.4, hTDO, IDO-1, IDO-2, IDO1, IDO2, indoleamine 2,3-dioxygenase 1, indoleamine 2,3-dioxygenase 2, TDO, TDO2, TDOa, tryptophan 2,3-dioxygenase, tryptophan 2,3-dioxygenase 2, tryptophan 2,3-dioxygenase-2, tryptophan-2,3-dioxygenase, v1g157887, vCG5163, XcTDO

ECTree

1 Oxidoreductases

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.13.11 With incorporation of two atoms of oxygen

1.13.11.11 tryptophan 2,3-dioxygenase

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Results	in table
2	Activating Compound
9810	AA Sequence
2	Application
14	Cloned(Commentary)
18	Cofactor
4	Crystallization (Commentary)
1191	Disease/ Diagnostics
4	Expression
54	General Information
4	General Stability
135	IC50 Value
146	Inhibitors
26	KM Value [mM]
1	Localization
4	Metals/Ions
3	Molecular Weight [Da]
39	Natural Substrates/ Products (Substrates)
55	Organism
9	Pathway
85	PDB ID
9	pH Optimum
3	Posttranslational Modification
24	Protein Variants
5	Purification (Commentary)
3	Reaction
45	Reference
63	Source Tissue
60	Substrates and Products (Substrate)
9	Subunits
64	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
8	Turnover Number [1/s]

Expression

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Expression on EC 1.13.11.11 - tryptophan 2,3-dioxygenase

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expression is strongly increased in synovial tissue and fibroblast-like synoviocytes of rheumatoid arthritis and adjuvant-induced arthritis. Immune cells express high amount of the enzyme (TDO2) at the peak stage of adjuvant-induced arthritis

2 entries

TDO2 gene expression is upregulated in leiomyoma expressing mut-MED12. The tissue mRNA levels of tryptophan 2,3-dioxygenase (TDO2), the rate limiting enzyme of tryptophan metabolism through the kynurenine pathway, is 36fold higher in leiomyomas expressing mutated mediator complex subunit 12 (mut-MED12) compared to adjacent myometrium, and 14fold higher compared to wild type-MED12 leiomyoma

Homo sapiens

P48775

765754

treated with interferon gamma stimulates hIDO1 expression

Homo sapiens

P14902, Q6ZQW0

765516