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1.13.11.11: tryptophan 2,3-dioxygenase

This is an abbreviated version!
For detailed information about tryptophan 2,3-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.11

Reaction

L-tryptophan
+
O2
=
N-formyl-L-kynurenine

Synonyms

33737, BRAFLDRAFT_210874, C28H8.11, EC 1.11.1.4, hTDO, IDO-1, IDO-2, IDO1, IDO2, indoleamine 2,3-dioxygenase 1, indoleamine 2,3-dioxygenase 2, TDO, TDO2, TDOa, tryptophan 2,3-dioxygenase, tryptophan 2,3-dioxygenase 2, tryptophan 2,3-dioxygenase-2, tryptophan-2,3-dioxygenase, v1g157887, vCG5163, XcTDO

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.11 tryptophan 2,3-dioxygenase

General Stability

General Stability on EC 1.13.11.11 - tryptophan 2,3-dioxygenase

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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
high tryptophan levels stabilize the active tetrameric conformation of the enzyme through binding noncatalytic exosites, resulting in rapid catabolism of tryptophan
in low tryptophan, the lack of tryptophan binding in the exosites destabilizes the tetramer into inactive monomers and dimers
one of the most rapidly degraded liver proteins with a half-life (t1/2) of about 2.3 h, relative to an average t1/2 of about 2-3 days for total liver protein
the nonmetabolizable analog alpha-methyl-tryptophan stabilizes tetrameric enzyme and thereby stably reduces tryptophanemia