1.13.11.19: cysteamine dioxygenase

This is an abbreviated version!
For detailed information about cysteamine dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.19

1.13.11.19

hypotaurine

sulfinic

3-mercaptopropionate

dioxygenation

nonheme

Reaction

Synonyms

2-aminoethanethiol dioxygenase, ADO, CDO, cysteamine oxygenase, Gm237, oxygenase, cysteamine, oxygenase, cysteamine di-, persulfurase

ECTree

1 Oxidoreductases

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.13.11 With incorporation of two atoms of oxygen

1.13.11.19 cysteamine dioxygenase

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Results	in table
19	Activating Compound
23	AA Sequence
1	Application
1	CAS Registry Number
2	Cloned(Commentary)
2	Crystallization (Commentary)
3	Disease/ Diagnostics
4	Expression
10	General Information
1	General Stability
23	Inhibitors
3	Ki Value [mM]
8	KM Value [mM]
3	Localization
10	Metals/Ions
7	Molecular Weight [Da]
16	Natural Substrates/ Products (Substrates)
39	Organism
3	Pathway
5	PDB ID
2	pH Optimum
1	Posttranslational Modification
3	Protein Variants
4	Purification (Commentary)
1	Reaction
3	Reaction Type
39	Reference
104	Source Tissue
8	Specific Activity [micromol/min/mg]
5	Storage Stability
64	Substrates and Products (Substrate)
3	Subunits
17	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Inhibitors

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Inhibitors on EC 1.13.11.19 - cysteamine dioxygenase

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1,3-dithiopropane

1,4-dithiobutane

2-mercaptoethanol

inhibition at high concentration, activation at low concentration

396416

8-hydroxyquinoline

Equus caballus

complete inhibition at 7.5 mM

396415

alpha,alpha'-dipyridyl

slight inhibition

azide

Fe(III)ADO incubated with azide displays a rhombic, high-spin (S = 5/2) EPR signal that closely resembles that of purified ADO. Azide may bind to the Fe(III)ADO active site by replacing a ligand with comparable donor strength, likely a solvent-derived hydroxide. Azide is unable to coordinate to cysteamine-bound Fe(III)ADO

765096

cyanide

Mus musculus

Q6PDY2

cyanide binds to either cysteamine- or Cys-bound Fe(III)ADO, binding causes the appearance of a dominant low-spin (S = 1/2) EPR signal and a small but noticeable change to the electronic absorption spectrum

cystamine

cysteamine

cysteine

diethyldithiocarbamate

Equus caballus

70% inhibition at 10 mM

396415

Iron

2 entries

KCN

Equus caballus

60-70% inhibition at 10 mM

396415

mercaptoethylguanidine

Sus scrofa

noncompetitive to cysteamine

396408

Neocuproine

Equus caballus

45-55% inhibition at 10 mM

396415

o-phenanthroline

Equus caballus

45-55% inhibition at 10 mM

pantetheine

sulfide, elemental sulfur, elemental selenium or hydroxylamine required in catalytic amount, inhibition when added over a critical concentration (with the exception of hydroxylamine)

Salicylaldoxime

slight inhibition

sulfide, elemental sulfur, elemental selenium or hydroxylamine required in catalytic amount, inhibition when added over a critical concentration (with the exception of hydroxylamine)

396333

Sulfide

Equus caballus

sulfide, elemental sulfur, elemental selenium or hydroxylamine required in catalytic amount, inhibition when added over a critical concentration (with the exception of hydroxylamine)

396333