1.13.11.31: arachidonate 12-lipoxygenase

This is an abbreviated version!
For detailed information about arachidonate 12-lipoxygenase, go to the full flat file.

Reaction

Synonyms

(12R)-lipoxygenase, (12R)-LOX, 11R-lipoxygenase, 11R-LOX, 12(R)-lipoxygenase, 12(S)-lipoxygenase, 12-hLO, 12-lipoxygenase, 12-LO, 12-LOX, 12/15 lipoxygenase, 12/15 Lox, 12/15-lipoxygenase, 12/15-lipoxygenases, 12/15-LO, 12/15-LOX, 12/15LO, 12DELTA-lipoxygenase, 12LO, 12R-lipoxygenase, 12R-LOX, 12R-LOX-2, 12S-lipoxygenase, 15-lipoxygenase, 15-LO, 15-LOX-1, 2-lipoxygenase, 2/15-lipoxygenase, ALOX 12, ALOX 12/15, ALOX12, Alox12b, Alox12e, Alox15, ALOX15B, ALOX5, arachidonate 12/15-lipoxygenase, C-12 lipoxygenase, cardiac 12/15-LOX, DELTA 12-lipoxygenase, epidermal-type lipoxygenase, hp-12LOX, human platelet 12-lipoxygenase, leukocyte-type 12-lipoxygenase, leukocyte-type 12-LOX, leukocyte-type 12/15-lipoxygenase, leukocyte-type lipoxygenase, leukotriene A4 synthase M, lipoxygenase 12, LOX, LOX-12, LOX1, LTA4 synthase, oxylipin-producing enzyme, oygenase, arachidonate 12-lip-, P-12LOX, p12-LO, p12-LOX, platelet 12-lipoxygenase, platelet-type 12(S)-lipoxygenase, platelet-type 12-human lipoxygenase, platelet-type 12-lipoxygenase, platelet-type 12-LOX, platelet-type 12LO, Platelet-type lipoxygenase 12, WP_046712474, zf12-LOX

ECTree

     1 Oxidoreductases

         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

             1.13.11 With incorporation of two atoms of oxygen

                1.13.11.31 arachidonate 12-lipoxygenase

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Results	in table
9	Activating Compound
24	AA Sequence
20	Application
1	CAS Registry Number
48	Cloned(Commentary)
3	Crystallization (Commentary)
4450	Disease/ Diagnostics
19	Expression
105	General Information
3	General Stability
96	IC50 Value
205	Inhibitors
24	kcat/KM [mM/s]
5	Ki Value [mM]
60	KM Value [mM]
26	Localization
22	Metals/Ions
9	Molecular Weight [Da]
76	Natural Substrates/ Products (Substrates)
603	Organism
10	Pathway
6	PDB ID
25	pH Optimum
4	pH Range
64	Protein Variants
29	Purification (Commentary)
1	Reaction
5	Reaction Type
173	Reference
209	Source Tissue
18	Specific Activity [micromol/min/mg]
12	Storage Stability
315	Substrates and Products (Substrate)
16	Subunits
249	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
1	Temperature Range [°C]
11	Temperature Stability [°C]
34	Turnover Number [1/s]

Crystallization

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Crystallization on EC 1.13.11.31 - arachidonate 12-lipoxygenase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

low-resolution 16 A structure of enzyme in solution, dynamic light scattering and SAXS analysis of hp-12LOX shows that this enzyme as a whole is stable in the dimeric form, while mutants without PLAT domains associate into larger aggregates

Homo sapiens

P18054

688398

modeling of the protein dimer

Homo sapiens

P18054

764187

crystals diffracting to high resolution (1.9 A) are obtained for a complex between the catalytic domain of leukocyte 12-lipoxygenase and the isoform-specific inhibitor, 4-(2-oxapentadeca-4-yne) phenylpropanoic acid (OPP)

Sus scrofa

P16469

728810