1.13.11.31: arachidonate 12-lipoxygenase

This is an abbreviated version!
For detailed information about arachidonate 12-lipoxygenase, go to the full flat file.

Reaction

Synonyms

(12R)-lipoxygenase, (12R)-LOX, 11R-lipoxygenase, 11R-LOX, 12(R)-lipoxygenase, 12(S)-lipoxygenase, 12-hLO, 12-lipoxygenase, 12-LO, 12-LOX, 12/15 lipoxygenase, 12/15 Lox, 12/15-lipoxygenase, 12/15-lipoxygenases, 12/15-LO, 12/15-LOX, 12/15LO, 12DELTA-lipoxygenase, 12LO, 12R-lipoxygenase, 12R-LOX, 12R-LOX-2, 12S-lipoxygenase, 15-lipoxygenase, 15-LO, 15-LOX-1, 2-lipoxygenase, 2/15-lipoxygenase, ALOX 12, ALOX 12/15, ALOX12, Alox12b, Alox12e, Alox15, ALOX15B, ALOX5, arachidonate 12/15-lipoxygenase, C-12 lipoxygenase, cardiac 12/15-LOX, DELTA 12-lipoxygenase, epidermal-type lipoxygenase, hp-12LOX, human platelet 12-lipoxygenase, leukocyte-type 12-lipoxygenase, leukocyte-type 12-LOX, leukocyte-type 12/15-lipoxygenase, leukocyte-type lipoxygenase, leukotriene A4 synthase M, lipoxygenase 12, LOX, LOX-12, LOX1, LTA4 synthase, oxylipin-producing enzyme, oygenase, arachidonate 12-lip-, P-12LOX, p12-LO, p12-LOX, platelet 12-lipoxygenase, platelet-type 12(S)-lipoxygenase, platelet-type 12-human lipoxygenase, platelet-type 12-lipoxygenase, platelet-type 12-LOX, platelet-type 12LO, Platelet-type lipoxygenase 12, WP_046712474, zf12-LOX

ECTree

     1 Oxidoreductases

         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

             1.13.11 With incorporation of two atoms of oxygen

                1.13.11.31 arachidonate 12-lipoxygenase

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Results	in table
9	Activating Compound
24	AA Sequence
20	Application
1	CAS Registry Number
48	Cloned(Commentary)
3	Crystallization (Commentary)
4450	Disease/ Diagnostics
19	Expression
105	General Information
3	General Stability
96	IC50 Value
205	Inhibitors
24	kcat/KM [mM/s]
5	Ki Value [mM]
60	KM Value [mM]
26	Localization
22	Metals/Ions
9	Molecular Weight [Da]
76	Natural Substrates/ Products (Substrates)
603	Organism
10	Pathway
6	PDB ID
25	pH Optimum
4	pH Range
64	Protein Variants
29	Purification (Commentary)
1	Reaction
5	Reaction Type
173	Reference
209	Source Tissue
18	Specific Activity [micromol/min/mg]
12	Storage Stability
315	Substrates and Products (Substrate)
16	Subunits
249	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
1	Temperature Range [°C]
11	Temperature Stability [°C]
34	Turnover Number [1/s]

Storage Stability

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Storage Stability on EC 1.13.11.31 - arachidonate 12-lipoxygenase

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STORAGE STABILITY

ORGANISM

UNIPROT

LITERATURE

-20°C, remains stable for 6 weeks

Homo sapiens

-

395411

-70°C, 1 month

Sus scrofa

-

395408

-70°C, 1 month, no appreciable loss of activity

Rattus norvegicus

-

395417

-70°C, 20% glycerol, 10 mM 2-mercaptoethanol, 0.3% Triton X-305, enzyme retains complete activity after 1 month

Sus scrofa

-

395428

-80�C, 10% glycerol

2 entries

-80°C, 10-20% glycerol

Homo sapiens

-

706032

-80°C, stable for at least 1 week

Bos taurus

-

395407

-80°C, stable for at least 4 months

Sus scrofa

-

395425

4°C, half-life of leukocyte enzyme is 2 h, half-life of platelet enzyme is 70 h

Bos taurus

-

395407

4°C, half-life: 24 h, markedly stabilized by 0.02 mM Fe2+

Sus scrofa

-

395408

4°C, half-life: less than 1 h

Mus musculus

-

395423

-80�C, 10% glycerol

Mus musculus

-

702435

-80�C, 10% glycerol

Danio rerio

-

702435