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1.13.11.34: arachidonate 5-lipoxygenase

This is an abbreviated version!
For detailed information about arachidonate 5-lipoxygenase, go to the full flat file.

Word Map on EC 1.13.11.34

Reaction

(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
=
leukotriene A4
+
H2O

Synonyms

5-lipoxygenase, 5-LO, 5-LO1, 5-LOX, 5DELTA-lipoxygenase, 5LO, 5LOX-1, ALOX5, arachidonate 5-LO, arachidonate:oxygen oxidoreductase, arachidonic 5-lipoxygenase, arachidonic acid 5-lipoxygenase, C-5-lipoxygenase, DELTA5-lipoxygenase, H5-LO, leukotriene A4 synthase, leukotriene-A4 synthase, lipoxygenase 15, lipoxygenase 5, lipoxygenase-1, LO-1, LOX-15, LOX-5, LTA synthase, LTA4 synthase, oxygenase, arachidonate, 5-lip-, PMNL 5-lipoxygenase

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.34 arachidonate 5-lipoxygenase

KI Value

KI Value on EC 1.13.11.34 - arachidonate 5-lipoxygenase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0019
(17S)-hydroperoxy-4,7,10,13,15,19-docosahexaenoyl lysophosphatidylcholine
-
pH 6.3, 25°C
0.00071
(2,4-dihydroxyphenyl)[3-(1-[hydroxy[(3,4,5-trihydroxyphenyl)methyl]amino]ethyl)phenyl]methanone
pH and temperature not specified in the publication
0.0009
(2,4-dihydroxyphenyl)[3-(1-[hydroxy[(4-hydroxyphenyl)methyl]amino]ethyl)phenyl]methanone
pH and temperature not specified in the publication
0.016
2-(3-acetylphenyl)propanoic acid
pH and temperature not specified in the publication
0.00136
2-(3-benzoylphenyl)propanoic acid
pH and temperature not specified in the publication
0.00267
2-(3-phenoxyphenyl)propanoic acid
pH and temperature not specified in the publication
0.0455
2-methyl-3-[(morpholine-4-carbonyl)amino]-3-oxopropanoic acid
pH and temperature not specified in the publication
0.00734
2-[3-(2-methylpropanoyl)phenyl]propanoic acid
pH and temperature not specified in the publication
0.00734
2-[3-(morpholine-4-carbonyl)phenyl]propanoic acid
pH and temperature not specified in the publication
0.00042
2-[3-[(4-hydroxyphenyl)carbamoyl]phenyl]propanoic acid
pH and temperature not specified in the publication
0.0057
2-[3-[hydroxy(phenyl)amino]phenyl]propanoic acid
pH and temperature not specified in the publication
0.00013
2-[4'-[(morpholin-4-yl)sulfanyl][1,1'-biphenyl]-3-yl]propanoic acid
pH and temperature not specified in the publication
0.0112
2-[4-(morpholine-4-carbonyl)phenyl]propanoic acid
pH and temperature not specified in the publication
0.17
3-(1-carboxyethyl)benzoic acid
pH and temperature not specified in the publication
0.00515
4-[(hydroxy[1-[3'-(morpholin-4-yl)[1,1'-biphenyl]-3-yl]ethyl]amino)methyl]phenol
pH and temperature not specified in the publication
0.00011
4-[[hydroxy(2-methyl-1-[3-[(morpholin-4-yl)oxy]phenyl]propyl)amino]methyl]phenol
pH and temperature not specified in the publication
0.025
5,8,11,14,17-eicosapentaenoic acid
-
-
0.0005
5-hydroperoxy-6,8,11,14-eicosatetraenoic acid
-
-
0.00032
5-[[hydroxy(2-methyl-1-[3-[(morpholin-4-yl)oxy]phenyl]propyl)amino]methyl]benzene-1,2,3-triol
pH and temperature not specified in the publication
0.15
8,11,13-cis-icosatrienoic acid
-
-
0.0398
arachidonate
pH and temperature not specified in the publication
0.0137 - 0.02
arachidonic acid
0.00038
arachidonoyl lysophosphatidylcholine
-
pH 6.3, 25°C
0.0016
delta-tocopherol-13'-carboxychromanol
pH not specified in the publication, temperature not specified in the publication
-
0.0022
delta-tocotrienol
pH not specified in the publication, temperature not specified in the publication
0.0008
delta-tocotrienol-13'-carboxychromanol
pH not specified in the publication, temperature not specified in the publication
-
0.001
ferrocenyl carboxylic acid
pH 7.5, 23°C
-
0.00059
[3-(1-[hydroxy[(3,4,5-trihydroxyphenyl)methyl]amino]ethyl)phenyl](morpholin-4-yl)methanone
pH and temperature not specified in the publication
0.00018
[3-(1-[hydroxy[(4-hydroxyphenyl)methyl]amino]ethyl)phenyl](morpholin-4-yl)methanone
pH and temperature not specified in the publication
0.0398
[3-(bromocarbonyl)phenyl](morpholin-4-yl)acetic acid
pH and temperature not specified in the publication
additional information
additional information
-
inhibition kinetics, overview
-