1.13.11.34: arachidonate 5-lipoxygenase
This is an abbreviated version!
For detailed information about arachidonate 5-lipoxygenase, go to the full flat file.
Word Map on EC 1.13.11.34
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1.13.11.34
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cyclooxygenase
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prostaglandin
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leukocyte
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neutrophil
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eicosanoids
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cox-2
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asthma
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indomethacin
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ionophore
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phospholipase
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zileuton
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polymorphonuclear
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thromboxane
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flap
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airway
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peritoneal
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5-hete
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platelet
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eosinophil
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mast
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cysteinyl
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allergic
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edema
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12-lipoxygenase
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histamine
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lta4
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nordihydroguaiaretic
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lipoxygenases
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paf
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ndga
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bronchoconstriction
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5-hydroxyeicosatetraenoic
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asthmatic
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basophil
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platelet-activating
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anaphylaxis
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zymosan
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antigen-induced
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lipoxins
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montelukast
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hetes
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mpges-1
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carrageenan-induced
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a23187-stimulated
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paf-induced
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pro-resolving
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synthesis
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bronchospasm
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medicine
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drug development
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14carachidonic
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pharmacology
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bronchoconstrictors
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ulcerogenic
- 1.13.11.34
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cyclooxygenase
- prostaglandin
- leukocyte
- neutrophil
-
eicosanoids
- cox-2
- asthma
- indomethacin
-
ionophore
- phospholipase
- zileuton
-
polymorphonuclear
-
thromboxane
- flap
- airway
- peritoneal
-
5-hete
- platelet
-
eosinophil
-
mast
-
cysteinyl
-
allergic
- edema
-
12-lipoxygenase
- histamine
- lta4
-
nordihydroguaiaretic
- lipoxygenases
- paf
- ndga
-
bronchoconstriction
-
5-hydroxyeicosatetraenoic
-
asthmatic
-
basophil
-
platelet-activating
- anaphylaxis
- zymosan
-
antigen-induced
-
lipoxins
- montelukast
-
hetes
- mpges-1
-
carrageenan-induced
-
a23187-stimulated
-
paf-induced
-
pro-resolving
- synthesis
- bronchospasm
- medicine
- drug development
-
14carachidonic
- pharmacology
-
bronchoconstrictors
-
ulcerogenic
Reaction
Synonyms
5-lipoxygenase, 5-LO, 5-LO1, 5-LOX, 5DELTA-lipoxygenase, 5LO, 5LOX-1, ALOX5, arachidonate 5-LO, arachidonate:oxygen oxidoreductase, arachidonic 5-lipoxygenase, arachidonic acid 5-lipoxygenase, C-5-lipoxygenase, DELTA5-lipoxygenase, H5-LO, leukotriene A4 synthase, leukotriene-A4 synthase, lipoxygenase 15, lipoxygenase 5, lipoxygenase-1, LO-1, LOX-15, LOX-5, LTA synthase, LTA4 synthase, oxygenase, arachidonate, 5-lip-, PMNL 5-lipoxygenase
ECTree
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Posttranslational Modification
Posttranslational Modification on EC 1.13.11.34 - arachidonate 5-lipoxygenase
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phosphoprotein
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Ca2+ and 5-lipoxygenase phosphorylation seem to be required for arachidonic acid-induced 5-lipoxygenase product formation
phosphoprotein
the amino acid sequence of 5-LO contains several protein kinase motifs, e.g. at Ser271 and Ser663, 5-LO is phosphorylated in vitro by the protein kinases p38 MAPK-regulated MAPKAPK-2/3, ERK1/2, CaMKII and PKA. Conditions that activate MAPKAPKs and ERKs (e.g. cell stress, and phorbol esters) induce nuclear translocation of 5-LO and enhance product formation in intact cells, and this process is susceptible to kinase inhibitors. Phosphorylation on Ser523 by PKA directly suppresses 5-LO catalysis both in vitro and in the cell, and prevents nuclear localization of 5-LO by inhibiting the nuclear import function of a nuclear import sequence close to the kinase motif
phosphoprotein
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5LO can be phosphorylated at three residues: Ser-271 (by MAP-KAP kinases), Ser-663 (by ERK2), and Ser-523 (by protein kinase A catalytic subunit)
phosphoprotein
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cellular 5-LO activity is regulated by both divalent cations and by phosphorylation, mitogen-activatedprotein kinasesandproteinkinase A can phosphorylate 5-LO in the catalytic domain
phosphoprotein
intracellular localisation and phosphorylation profile of the human 5-lipoxygenase DELTA13 isoform differs from that of full-length wild-type enzyme. Mutant 5-LODELTA13 is hyperphosphorylated on S523 and S273 compared to wild-type 5-LO1
phosphoprotein
wild-type 5-LO shows a slight phosphorylation at S271 and S523, while mutant isozymes 5-LOp12 and 5-LODELTA13 are highly phosphorylated at Ser271 and 5-LOp12 also at Ser523