1.13.11.34: arachidonate 5-lipoxygenase

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For detailed information about arachidonate 5-lipoxygenase, go to the full flat file.

Word Map on EC 1.13.11.34

1.13.11.34

cyclooxygenase

prostaglandin

leukocyte

neutrophil

eicosanoids

cox-2

asthma

indomethacin

ionophore

phospholipase

zileuton

polymorphonuclear

thromboxane

flap

airway

peritoneal

5-hete

platelet

eosinophil

mast

cysteinyl

allergic

edema

12-lipoxygenase

histamine

lta4

nordihydroguaiaretic

lipoxygenases

paf

ndga

bronchoconstriction

5-hydroxyeicosatetraenoic

asthmatic

basophil

platelet-activating

anaphylaxis

zymosan

antigen-induced

lipoxins

montelukast

hetes

mpges-1

carrageenan-induced

a23187-stimulated

paf-induced

pro-resolving

synthesis

bronchospasm

medicine

drug development

14carachidonic

pharmacology

bronchoconstrictors

ulcerogenic

Reaction

(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate

Synonyms

5-lipoxygenase, 5-LO, 5-LO1, 5-LOX, 5DELTA-lipoxygenase, 5LO, 5LOX-1, ALOX5, arachidonate 5-LO, arachidonate:oxygen oxidoreductase, arachidonic 5-lipoxygenase, arachidonic acid 5-lipoxygenase, C-5-lipoxygenase, DELTA5-lipoxygenase, H5-LO, leukotriene A4 synthase, leukotriene-A4 synthase, lipoxygenase 15, lipoxygenase 5, lipoxygenase-1, LO-1, LOX-15, LOX-5, LTA synthase, LTA4 synthase, oxygenase, arachidonate, 5-lip-, PMNL 5-lipoxygenase

ECTree

1 Oxidoreductases

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.13.11 With incorporation of two atoms of oxygen

1.13.11.34 arachidonate 5-lipoxygenase

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Results	in table
89	Activating Compound
57	AA Sequence
18	Application
1	CAS Registry Number
32	Cloned(Commentary)
7	Crystallization (Commentary)
5060	Disease/ Diagnostics
8	Expression
35	General Information
2	General Stability
611	IC50 Value
764	Inhibitors
6	kcat/KM [mM/s]
32	Ki Value [mM]
36	KM Value [mM]
61	Localization
71	Metals/Ions
13	Molecular Weight [Da]
113	Natural Substrates/ Products (Substrates)
323	Organism
15	Pathway
20	PDB ID
21	pH Optimum
2	pH Range
1	pI Value
7	Posttranslational Modification
51	Protein Variants
35	Purification (Commentary)
5	Reaction
5	Reaction Type
184	Reference
258	Source Tissue
12	Specific Activity [micromol/min/mg]
12	Storage Stability
263	Substrates and Products (Substrate)
19	Subunits
203	Synonyms
1	Systematic Name
19	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Temperature Stability [°C]
7	Turnover Number [1/s]

Sequence

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Sequence on EC 1.13.11.34 - arachidonate 5-lipoxygenase

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P09917 pBLAST

LOX5_HUMAN

Homo sapiens

674

77983

Swiss-Prot